1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18703349.csml convertedTime:2009.07.01.11:21

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Negative regulation of cytoplasmic RNA-mediated antiviral signaling.
Authors Komuro A, Bamming D, Horvath CM.
Affiliation Department of Medicine, Northwestern University, Evanston, IL 60208, USA.
Abstract The recent, rapid progress in our understanding of cytoplasmic RNA-mediatedantiviral innate immune signaling was initiated by the discovery of retinoicacid-inducible gene I (RIG-I) as a sensor of viral RNA. It is now widelyrecognized that RIG-I and related RNA helicases, melanomadifferentiation-associated gene-5 (MDA5) and laboratory of genetics andphysiology-2 (LGP2), can initiate and/or regulate RNA and virus-mediated type IIFN production and antiviral responses. As with other cytokine systems,production of type I IFN is a transient process, and can be hazardous to thehost if unregulated, resulting in chronic cellular toxicity or inflammatory andautoimmune diseases. In addition, the RIG-I-like receptor (RLR) system is afundamental target for virus-encoded immune suppression, with many indirect anddirect examples of interference described. In this article, we review thecurrent understanding of endogenous negative regulation in RLR signaling andexplore direct inhibition of RLR signaling by viruses as a host immune evasionstrategy.
PMID 18703349
Model Abstract

Entity

G010228:IFN-beta G010405:A20 MO000000058:NF-kappaB MO000000277:p53 MO000000289:TNF-alpha MO000007694:IRF-3 MO000008179:PKR MO000016591:A20 MO000016608:IKK-i MO000016660:IFNbeta MO000016963:TRAF3 MO000017197:Pin1 MO000019331:TBK1 MO000022224:dsRNA MO000041125:TRIF MO000041169:CYLD MO000041456:IRF-3{p} MO000044361:UbcH8 MO000066987:DDX58 MO000067169:ATG12 MO000070429:ATG5 MO000094908:MAVS MO000103999:IFIH1 MO000107907:RNF125 e1: e10:Poly I:C:IFIH1:MAVS:TRAF3 e11:ssRNA:DDX58 e12:POly I:C e13:Poly I:C: IFIH1 e14:LGP2 e15:LGP2 e16:ROS e17:RIG-I e18:MAVS e19:DDX58:dsRNA:MAVS e2: e20:DDX58:dsRNA:MAVS:LGP2 e21:Poly I:C:IFIH1:MAVS e22:Poly I:C:IFIH1:MAVS:LGP2 e23:ssRNA:DDX58(2) e24:ssRNA:DDX58:LGP2 e25:TNF e26:DDX58:dsRNA:MAVS:TRAF3:TBK1:IKK-i e27:Poly I:C:IFIH1:MAVS:TRAF3:TBK1:IKK-i e28:IRF-3{p}:IRF-3{p} e29:IRF-3{p}:IRF-3{p} e3: e30:IRF-3{p}:IRF-3{p}:DNA e31:DNA e32:IRF-3{p}:Pin1 e33:Trans IRF-3{p}:Pin1 e34:Pin1:p53 e35:Trans IRF-3{p}{ub}:Pin1 e36:SIKE e37:SIKE:TBK1:IKK-i e38:ATG5:ATG12 e39:DDX58:dsRNA:ATG5:ATG12 e4: e40:Poly I:C:IFIH1:ATG5:ATg12 e41:MAVS:ATG5:ATG12 e42:RNF125:UbcH8 e43:RNF125:dsRNA:DDX58 e44:RNF125:dsRNA:DDX58{ub} e45:RNF125:Poly i:C:IFIH1 e46:MAVS{ub} e47:RNF125:Poly i:C:IFIH1{ub} e48:TRIM25 e49:DDX58{ub}:dsRNA e5:DDX58:dsRNA e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:ssRNA e60: e61: e62: e63:DUBA e64:DDX58:dsRNA:MAVS:TRAF3 e65:G protein e66:DDX58:dsRNA:G protein e67:V protein e68:Poly I:C:IFIH1:V protein e69:NS1 e7: e70:NS1:PKR e71:PRR ligand e72:CYLD:TBK1:IKK-i e73:IFN e74:IFN e75:DDx58:dsRNA:MAVS:NS1 e76:DDX58{ub}:dsRNA:CYLD e77:DDX58{ub}:dsRNA:CYLD e78:DAK e79:POly I:C:IFIH1:DAK e8: e80:CYLD{p}:TBK1:IKK-i e81:NLRX1 e82:NLRX1:MAVS e83:dsRNA e84:Shigella e85:NS3 e86:Hepatitis C virus polyprotein e87:Cleaved fragments e88:Cleaved trif fragment1 e89:Cleaved trif fragment2 e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p7 p8 p9
Model Detail
421.0, 1345.0
30.0, 30.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p40 p41

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
599.0, 1427.0
26.0, 26.0

A20

--

G010405

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p16

p17

true true true true

csml-variable:Double

m93378

10

false

infinite

0

unit false false false
TRANSFACG010405

--

Go back
532.0, 1016.0
24.0, 24.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1001.0, 701.0
22.0, 22.0

p53

--

MO000000277

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m220

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000277

--

Go back
1326.0, 330.0
19.0, 19.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
613.0, 825.0
22.0, 22.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1093.0, 1061.0
22.0, 22.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
806.0, 974.0
20.0, 20.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

p15 p20

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
654.0, 594.0
20.0, 20.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p19 p28 p54

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
48.0, 1160.0
24.0, 24.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40 p41

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
1027.0, 659.0
18.0, 18.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43 p44 p45

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
914.0, 814.0
20.0, 20.0

Pin1

--

MO000017197

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p24 p26

true true true true

csml-variable:Double

m2065

10

false

infinite

0

unit false false false
InterProIPR000297
TRANSPATHMO000017197

--

Go back
522.0, 510.0
20.0, 20.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p19 p28 p54

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
264.0, 352.0
23.0, 23.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
906.0, 1598.0
20.0, 20.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
238.0, 1058.0
20.0, 20.0

CYLD

--

MO000041169

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p54

true true true true

csml-variable:Double

m19042

10

false

infinite

0

unit false false false
TRANSPATHMO000041169

--

Go back
747.0, 815.0
18.0, 18.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p21 p24

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
211.0, 919.0
18.0, 18.0

UbcH8

--

MO000044361

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m22076

10

false

infinite

0

unit false false false
TRANSPATHMO000044361

--

Go back
333.0, 485.0
22.0, 22.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
943.0, 447.0
18.0, 18.0

ATG12

--

MO000067169

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m42024

10

false

infinite

0

unit false false false
TRANSPATHMO000067169

--

Go back
983.0, 487.0
18.0, 18.0

ATG5

--

MO000070429

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m45270

10

false

infinite

0

unit false false false
TRANSPATHMO000070429

--

Go back
493.0, 553.0
22.0, 22.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p12 p32 p37 p56

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
482.0, 422.0
20.0, 20.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
350.0, 926.0
20.0, 20.0

RNF125

--

MO000107907

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p34 p36 p37 p38

true true true true

csml-variable:Double

m80707

10

false

infinite

0

unit false false false
TRANSPATHMO000107907

--

Go back
101.21416152228736, 233.00084204008775
1166.7075806525193, 1694.0594071074597

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
911.0, 573.0
18.176470588235297, 30.294117647058826

Poly I:C:IFIH1:MAVS:TRAF3

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p44

p19

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
262.5, 540.0
19.35994000999834, 23.7060489918347

ssRNA:DDX58

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p13 p14

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
480.0, 342.0
48.72161480235493, 27.608915054667786

POly I:C

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
569.5, 455.0
21.058323612731222, 25.785702382936176

Poly I:C: IFIH1

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p12 p31 p36 p38 p47 p53

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
652.0, 903.5
23.04, 17.279999999999998

LGP2

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5

p7 p8 p9 p11 p14

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
500.0, 1415.0
47.17993079584775, 25.162629757785467

LGP2

--

e15

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p4 p6

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1076.0, 335.5
24.780316344463973, 16.10720562390158

ROS

--

e16

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p57 p59

p58

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
640.0, 1257.0
40.84775086505191, 21.785467128027683

RIG-I

--

e17

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p7

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
702.0, 1340.0
44.688581314878896, 23.833910034602077

MAVS

--

e18

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p8

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
317.5, 589.0
21.211965498256564, 29.59809139291614

DDX58:dsRNA:MAVS

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p9 p45 p50

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
101.21416152228736, 233.00084204008775
1166.7075806525193, 1694.0594071074597

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
386.0, 855.0
20.647058823529417, 34.411764705882376

DDX58:dsRNA:MAVS:LGP2

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
711.5, 643.0
24.597357313268503, 34.32189392549092

Poly I:C:IFIH1:MAVS

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p11 p44

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
850.0, 735.0
20.294117647058826, 33.82352941176471

Poly I:C:IFIH1:MAVS:LGP2

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
239.5, 733.0
24.994000999833354, 30.604899183469417

ssRNA:DDX58(2)

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
297.5, 801.0
21.535511102954672, 30.049550376215812

ssRNA:DDX58:LGP2

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p13

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
844.0, 1393.0
55.7439446366782, 29.730103806228374

TNF

--

e25

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p15

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
562.0, 691.0
20.91176470588235, 34.852941176470594

DDX58:dsRNA:MAVS:TRAF3:TBK1:IKK-i

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p20 p40

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
930.0, 683.0
20.73529411764706, 34.558823529411775

Poly I:C:IFIH1:MAVS:TRAF3:TBK1:IKK-i

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p41

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
746.5, 980.0
19.645725712381275, 24.055990668221966

IRF-3{p}:IRF-3{p}

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
802.5, 1196.0
19.645725712381275, 24.055990668221966

IRF-3{p}:IRF-3{p}

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
124.54831313533765, 256.33499365313827
1120.0392774264183, 1647.391103881361

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
782.0, 1455.5
60.0, 17.0

IRF-3{p}:IRF-3{p}:DNA

--

e30

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p23

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
722.0, 1405.5
60.0, 13.0

DNA

--

e31

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p23

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
841.5, 876.0
20.33161139810031, 24.89585069155141

IRF-3{p}:Pin1

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
913.5, 936.0
20.33161139810031, 24.89585069155141

Trans IRF-3{p}:Pin1

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p27

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1085.5, 735.0
21.18896850524913, 25.94567572071322

Pin1:p53

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
993.5, 1004.0
20.33161139810031, 24.89585069155141

Trans IRF-3{p}{ub}:Pin1

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
755.0, 584.5
25.731535520225396, 15.867780237472335

SIKE

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
748.5, 528.0
23.342631675536797, 32.5711139658653

SIKE:TBK1:IKK-i

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
884.0, 443.0
23.121546961325965, 25.690607734806633

ATG5:ATG12

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p30 p31 p32

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
802.0, 343.0
20.73529411764706, 34.55882352941177

DDX58:dsRNA:ATG5:ATG12

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
167.7164936194813, 297.16975897597615
1033.7029164581324, 1565.7215732356833

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
693.0, 362.0
21.0, 35.0

Poly I:C:IFIH1:ATG5:ATg12

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
848.5, 477.0
22.135254175077996, 30.886401174527435

MAVS:ATG5:ATG12

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
269.5, 975.0
20.462256290618225, 25.05582402932845

RNF125:UbcH8

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
519.5, 975.0
24.644705450541387, 34.38796109377868

RNF125:dsRNA:DDX58

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
407.5, 1063.0
24.644705450541387, 34.38796109377868

RNF125:dsRNA:DDX58{ub}

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

p40

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
445.5, 721.0
20.78583226280052, 29.003486878326303

RNF125:Poly i:C:IFIH1

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
669.0, 753.0
22.0, 22.0

MAVS{ub}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
601.5, 929.0
20.78583226280052, 29.003486878326303

RNF125:Poly i:C:IFIH1{ub}

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p41

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
220.5, 644.0
14.616824310726507, 23.702958341718656

TRIM25

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
452.0, 575.0
16.856353591160236, 18.729281767955804

DDX58{ub}:dsRNA

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p51

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
412.5, 390.0
22.37293784369272, 27.39543409431762

DDX58:dsRNA

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p4 p10 p30 p34 p42 p46

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
399.1787394221502, 1128.962861165192
545.6629393196628, 494.85633416885736

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
458.11440139708566, 1140.6902368770418
319.0654803470653, 479.6143526236154

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
406.29166414326306, 1135.5677198347976
531.4370898774378, 481.6466168296479

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
407.30779624627917, 1136.5838519378126
529.4048256714048, 479.6143526236154

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
399.1787394221502, 1128.962861165192
545.6629393196628, 494.85633416885736

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
399.1787394221502, 1128.962861165192
545.6629393196628, 494.85633416885736

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
407.30779624627917, 1136.5838519378126
529.4048256714048, 479.6143526236154

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
797.5025238044734, 1332.1892817684186
34.09002230144946, 30.86044124131226

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
708.0828987390544, 1474.4477761906778
96.5325497865325, 87.38736085938764

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
399.1787394221502, 1128.962861165192
545.6629393196628, 494.85633416885736

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
226.0, 430.5
52.51479938609954, 27.132646349484762

ssRNA

--

e6

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
527.7884239857638, 1348.8729270382798
17.280343520785166, 8.32016539889658

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
527.2113844021826, 1324.060224944289
59.14655731707111, 106.46380317072813

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
552.024086496174, 1393.30497497403
9.232633337298884, 9.232633337298914

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1079.0, 591.5
26.757898973636543, 16.500704367075866

DUBA

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p43

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
494.0, 631.0
20.91176470588235, 34.852941176470594

DDX58:dsRNA:MAVS:TRAF3

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p18

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1126.0, 817.0
12.927034611786715, 29.83161833489241

G protein

--

e65

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p46

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1053.5, 862.0
20.241328684162237, 28.243714443017083

DDX58:dsRNA:G protein

--

e66

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p46

p40

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1005.0, 352.5
21.28, 15.959999999999999

V protein

--

e67

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p47

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1082.5, 411.0
18.481556248853003, 25.788218021655357

Poly I:C:IFIH1:V protein

--

e68

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p47

p41

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1015.0, 1056.5
25.87643389011874, 15.957134232239891

NS1

--

e69

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p48 p49 p50

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
116.54299739193414, 239.81787101510824
1144.1766504243985, 1621.2687592729517

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
937.5, 1111.0
21.50741543076154, 26.33561073154475

NS1:PKR

--

e70

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p48

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1297.0, 1180.5
22.42530755711775, 14.576449912126535

PRR ligand

--

e71

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p49

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
281.5, 1138.0
20.233437327950078, 28.23270324830244

CYLD:TBK1:IKK-i

--

e72

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p54

p55

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
834.0, 1504.0
44.06574394463668, 23.501730103806228

IFN

--

e73

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p49

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1288.0, 1507.0
15.15247895229186, 34.967259120673525

IFN

--

e74

cso30:c:Protein

cso30:i:CC_Extracellular

--

p49

p6

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1127.0, 921.0
18.0, 30.0

DDx58:dsRNA:MAVS:NS1

--

e75

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p50

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
237.5, 817.0
21.590750596439715, 30.126628739218212

DDX58{ub}:dsRNA:CYLD

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p51

p52

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
361.5, 1017.0
21.590750596439715, 30.126628739218212

DDX58{ub}:dsRNA:CYLD

--

e77

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p51 p52

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
856.0, 531.5
23.839999999999996, 17.88

DAK

--

e78

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p53

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
777.5, 421.0
21.259313635529455, 29.664158561203884

POly I:C:IFIH1:DAK

--

e79

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p53

p41

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
120.6306869571732, 268.43169797178194
1097.6222944983547, 1593.7475716116148

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
265.5, 1302.0
20.233437327950078, 28.23270324830244

CYLD{p}:TBK1:IKK-i

--

e80

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p55

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1098.0, 526.0
12.37979420018709, 28.568755846585592

NLRX1

--

e81

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p56 p57 p58 p59

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1012.5, 546.0
22.5934010998167, 27.665389101816366

NLRX1:MAVS

--

e82

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p56

p10

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1300.0, 440.0
23.0, 23.0

dsRNA

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1310.5, 528.0
26.893391403143347, 39.356182541185376

Shigella

--

e84

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p59

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
963.0, 1198.5
25.76, 19.320000000000004

NS3

--

e85

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p20 p60 p61

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
1099.5, 1258.0
17.498490641980275, 28.375930770778822

Hepatitis C virus polyprotein

--

e86

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p60

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1047.0, 1335.0
25.916140149339462, 25.05226881102815

Cleaved fragments

--

e87

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p60

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
947.0, 1656.5
25.248540953914265, 15.569933588247133

Cleaved trif fragment1

--

e88

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p61

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1066.0, 1661.5
22.879999999999995, 17.159999999999997

Cleaved trif fragment2

--

e89

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p61

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
113.53119246447744, 230.04552492845596
1092.6110466403898, 1572.845971566934

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
334.0, 394.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000066987

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m41844*0.1

nodelay

--

true

0

false

PMID: 18703349,17038590,17038589 This RIG-I region has the ability to recognize 5¡ì-triphosphorylated ends of double-stranded (ds) or single-stranded (ss) RNA

Go back
371.0, 491.0
18.0, 18.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000094908 e82

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c22 : 1
stoichiometry:c164 : 1
stoichiometry:c23 : 1

m5*m68199*0.1

nodelay

--

true

0

false

PMID: 18703349,17020950 Mechanistic experiments found that LGP2 co-immunoprecipitates with the adaptor protein, IPS-1/MAVS/CARDIF/VISA, and exhibits competitive binding with the downstream kinase, IKKi/IKK¦Å for a common site in IPS-1 PMID: 18703349 Mechanistic studies suggests that NLRX1 competes with RIG-I for IPS-1 interaction, implying that association between RIG-I and IPS-1 through CARD?CARD interaction is disrupted by NLRX1 in the mitochondrial compartment.

Go back
713.0, 741.0
22.0, 22.0

p9

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 e14

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c29 : 1
stoichiometry:c31 : 1

m21*m14*0.1

nodelay

--

true

0

false

PMID: 18703349, 17020950 Mechanistic experiments found that LGP2 co-immunoprecipitates with the adaptor protein, IPS-1/MAVS/CARDIF/VISA, and exhibits competitive binding with the downstream kinase, IKKi/IKK¦Å for a common site in IPS-1

Go back
591.0, 567.0
18.0, 18.0

p10

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000094908

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m13*m68199*0.1

nodelay

--

true

0

false

PMID: 18703349,17020950 Mechanistic experiments found that LGP2 co-immunoprecipitates with the adaptor protein, IPS-1/MAVS/CARDIF/VISA, and exhibits competitive binding with the downstream kinase, IKKi/IKK¦Å for a common site in IPS-1

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262.0, 642.0
19.0, 19.0

p13

p13

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e11 e24

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c37 : 1
stoichiometry:c33 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 18703349,17190814 LGP2 has also been demonstrated to associate with RIG-I to inhibit its auto-oligomerizaton via the LGP2 C-terminal region comparable to the RIG-I RD PMID: 18703349,18243112 In this model, dimerization of RIG-I by 5¡ì-triphosphorylated ssRNA, proposed to be an active form of RIG-I , is replaced by a RIG-I:LGP2 hetero-oligomer.

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326.0, 694.0
19.0, 19.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e14

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m11*m14*0.1

nodelay

--

true

0

false

PMID: 18703349, 17020950 Mechanistic experiments found that LGP2 co-immunoprecipitates with the adaptor protein, IPS-1/MAVS/CARDIF/VISA, and exhibits competitive binding with the downstream kinase, IKKi/IKK¦Å for a common site in IPS-1 PMID: 18703349,18243112 In this model, dimerization of RIG-I by 5¡ì-triphosphorylated ssRNA, proposed to be an active form of RIG-I , is replaced by a RIG-I:LGP2 hetero-oligomer.

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862.0, 1310.0
20.0, 20.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016591

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m1585*0.1

nodelay

--

true

0

false

PMID:18703349,2118515 A20 was originally identified as a TNF-inducible gene in human umbilical vein endothelial cells and was found to be induced by a wide range of stimuli including NF-KappaB

Go back
602.0, 1286.0
19.0, 19.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000058

G010405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m26*0.1

nodelay

--

true

0

false

PMID:18703349,2118515 A20 was originally identified as a TNF-inducible gene in human umbilical vein endothelial cells and was found to be induced by a wide range of stimuli including NF-KappaB

Go back
806.0, 1110.0
19.0, 19.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010405

MO000016591

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m93378*0.1

nodelay

--

true

0

false

PMID:18703349,2118515 A20 was originally identified as a TNF-inducible gene in human umbilical vein endothelial cells and was found to be induced by a wide range of stimuli including NF-KappaB

Go back
573.0, 593.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000016608 e64

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c46 : 1
stoichiometry:c45 : 1
stoichiometry:c47 : 1

m3902*m1599*m65*0.1

nodelay

--

true

0

false

PMID: 18703349, 17020950 Mechanistic experiments found that LGP2 co-immunoprecipitates with the adaptor protein, IPS-1/MAVS/CARDIF/VISA, and exhibits competitive binding with the downstream kinase, IKKi/IKK¦Å for a common site in IPS-1 PMID: 18703349 Experiments indicate that A20 intervenes downstream of the mitochondrial adaptor protein IPS-1 but upstream of the kinases (TBK1 and IKKi) that phosphorylate IRF-3.

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833.0, 633.0
21.0, 21.0

p18

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000016608 e10

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c121 : 1
stoichiometry:c50 : 1

m3902*m1599*m10*0.1

nodelay

--

true

0

false

PMID: 18703349, 17020950 Mechanistic experiments found that LGP2 co-immunoprecipitates with the adaptor protein, IPS-1/MAVS/CARDIF/VISA, and exhibits competitive binding with the downstream kinase, IKKi/IKK¦Å for a common site in IPS-1 PMID: 18703349 Experiments indicate that A20 intervenes downstream of the mitochondrial adaptor protein IPS-1 but upstream of the kinases (TBK1 and IKKi) that phosphorylate IRF-3.

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262.0, 486.0
19.0, 19.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000066987

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m6*m41844*0.1

nodelay

--

true

0

false

PMID: 18703349,17038590,17038589 This RIG-I region has the ability to recognize 5¡ì-triphosphorylated ends of double-stranded (ds) or single-stranded (ss) RNA

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614.0, 770.0
19.0, 19.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e26 MO000007694 MO000016591 e85

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c177 : 1
stoichiometry:c53 : 1

m27*m977*0.1

nodelay

--

true

0

false

PMID: 18703349,12702807 The NS3/4A protease function was known to be essential for proper posttranslational cleavage of the hepatitis C virus polyprotein when it was also identified as responsible for inhibition of IRF3 phosphorylation

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746.0, 878.0
19.0, 19.0

p21

p21

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 18703349,15474016,16306043,15661910 Expression of A20 blocks the constitutively active RIG-I N-terminus from signaling IRF-3 phosphorylation, dimerization, and DNA binding as well as Sendai virus, NDV and dsRNA-mediated IFNbeta promoter activity

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755.0, 1115.0
17.0, 17.0

p22

p22

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18703349,15474016,16306043,15661910 Expression of A20 blocks the constitutively active RIG-I N-terminus from signaling IRF-3 phosphorylation, dimerization, and DNA binding as well as Sendai virus, NDV and dsRNA-mediated IFNbeta promoter activity

Go back
802.0, 1262.0
19.0, 19.0

p23

p23

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e29 e31

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m30*m32*0.1

nodelay

--

true

0

false

PMID: 18703349,15474016,16306043,15661910 Expression of A20 blocks the constitutively active RIG-I N-terminus from signaling IRF-3 phosphorylation, dimerization, and DNA binding as well as Sendai virus, NDV and dsRNA-mediated IFNbeta promoter activity

Go back
842.0, 814.0
19.0, 19.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041456 MO000017197

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m19324*m2065*0.1

nodelay

--

true

0

false

PMID: 18703349 Due to a neighboring proline at position 340, phosphorylation of Ser 339 produces a binding site for the WW domain of the peptidyl-prolyl isomerase, Pin1.

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915.0, 879.0
17.0, 17.0

p25

p25

cso30:i:ME_Isomerization

cso30:i:CC_Cytosol

--

e32

MO000017197 e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 18703349 This interaction possibly subjects IRF3 to cis?trans isomerization around the Ser-Pro peptide bond.

Go back
922.0, 738.0
19.0, 19.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017197 MO000000277

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m2065*m220*0.1

nodelay

--

true

0

false

PMID: 18703349,12397362,12397361 For example, Pin1 association with the tumor suppressor p53 generates conformational changes that enhances transactivation activity

Go back
994.0, 938.0
19.0, 19.0

p27

p27

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18703349 For IRF-3, Pin1 association was demonstrated to facilitate ubiquitin-mediated proteosomal degradation.

Go back
653.5, 534.0
20.5, 20.5

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000016608 MO000019331

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m37*m1599*m3902*0.1

nodelay

--

true

0

false

PMID: 18703349,16281057 Suppressor of IKK-epsilon, SIKE, has been identified as an IKKepsilon-associated protein by yeast two-hybrid screening PMID: 18703349 Further characterization of SIKE revealed that it also can associates with TBK1 and that SIKE expression can efficiently inhibit IKK¦Å, TBK1, TRIF, TLR3 and RIG-I-mediated IFN¦Â and interferon stimulated response element (ISRE) promoter activation.

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906.0, 522.0
19.0, 19.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000070429 MO000067169

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m45270*m42024*0.1

nodelay

--

true

0

false

PMID: 18703349 The small ubiquitin-like Atg12 becomes conjugated to its substrate, Atg5, to produce the Atg5?Atg12 conjugate, a key regulator of the autophagic process that associates directly with the CARD domains of RIG-I, MDA5 and IPS-1.

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569.0, 365.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000103999

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m12*m76904*0.1

nodelay

--

true

0

false

PMID: 18703349,16625202,16714379 For MDA5 neither biological substrate specificity nor exact RNA binding have been clearly specified experimentally, however MDA5 is thought to be the primary receptor for signaling initiated by cytoplasmic accumulation of the well-studied synthetic dsRNA analog, poly(I:C)

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870.0, 374.0
19.0, 19.0

p29

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 e5

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m39*m5*0.1

nodelay

--

true

0

false

PMID: 18703349 The small ubiquitin-like Atg12 becomes conjugated to its substrate, Atg5, to produce the Atg5?Atg12 conjugate, a key regulator of the autophagic process that associates directly with the CARD domains of RIG-I, MDA5 and IPS-1.

Go back
674.0, 458.0
19.0, 19.0

p29

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 e13

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m39*m13*0.1

nodelay

--

true

0

false

PMID: 18703349 The small ubiquitin-like Atg12 becomes conjugated to its substrate, Atg5, to produce the Atg5?Atg12 conjugate, a key regulator of the autophagic process that associates directly with the CARD domains of RIG-I, MDA5 and IPS-1.

Go back
634.0, 482.0
19.0, 19.0

p29

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e38

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m68199*m39*0.1

nodelay

--

true

0

false

PMID: 18703349 The small ubiquitin-like Atg12 becomes conjugated to its substrate, Atg5, to produce the Atg5?Atg12 conjugate, a key regulator of the autophagic process that associates directly with the CARD domains of RIG-I, MDA5 and IPS-1.

Go back
229.0, 881.0
21.0, 21.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000107907 MO000044361

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m80707*m22076*0.1

nodelay

--

true

0

false

PMID: 18703349 RNF125 was identified as an UbcH8 interacting protein by yeast two-hybrid screening based on the prediction that UbcH8, which is an E2 enzyme for both ubiquitin and ISG15, might associate with the E3 ligase for RIG-I.

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414.0, 926.0
20.0, 20.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000107907 e5

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c93 : 1

m80707*m5*0.1

nodelay

--

true

0

false

PMID: 18703349 The N-terminal region of RNF125 associates with RIG-I via the CARD and RNA helicase domain but not with the RD, and expression of RNF125 increases RIG-I ubiquitination and destabilization.

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417.0, 981.0
21.0, 21.0

p35

p35

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18703349 The N-terminal region of RNF125 associates with RIG-I via the CARD and RNA helicase domain but not with the RD, and expression of RNF125 increases RIG-I ubiquitination and destabilization.

Go back
490.0, 866.0
19.0, 19.0

p36

p36

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000107907 e13

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m80707*m13*0.1

nodelay

--

true

0

false

PMID: 18703349 Both MDA5 and IPS-1 were also shown to be ubiquitination targets of RNF125.

Go back
610.0, 686.0
19.0, 19.0

p36

p37

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000107907 MO000094908

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m80707*m68199*0.1

nodelay

--

true

0

false

PMID: 18703349 Both MDA5 and IPS-1 were also shown to be ubiquitination targets of RNF125.

Go back
389.0, 589.0
21.0, 21.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000107907

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m13*m80707*0.1

nodelay

--

true

0

false

PMID: 18473349 Both MDA5 and IPS-1 were also shown to be ubiquitination targets of RNF125.

Go back
530.0, 790.0
19.0, 19.0

p36

p39

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e45

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 18703349 Both MDA5 and IPS-1 were also shown to be ubiquitination targets of RNF125.

Go back
510.0, 1278.0
19.0, 19.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18703349 Moreover, it was observed that LGP2 mRNA and protein are inducible by dsRNA or IFN treatments as well as virus infection, consistent with LGP2 functioning as a negative feedback regulator.

Go back
394.0, 1206.0
19.0, 19.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e44 e26 e66

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c128 : 1
stoichiometry:c130 : 1
stoichiometry:c108 : 1

m93217*m27*0.1

nodelay

--

true

0

false

PMID: 18473349 As a result, virus or dsRNA-mediated IFN¦Â production is inhibited by expression of RNF125 and enhanced by RNF125 knock-down. PMID: 18703349 Coexpression studies of RIG-I and MDA5 with the hMPV G protein revealed that the G protein can specifically block RIG-I-mediated IFNbeta induction.

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438.0, 1162.0
19.0, 19.0

p40

p41

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e47 e27 e68 e79

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c129 : 1
stoichiometry:c134 : 1
stoichiometry:c154 : 1
stoichiometry:c112 : 1

m93217*m28*0.1

nodelay

--

true

0

false

PMID: 18473349 As a result, virus or dsRNA-mediated IFN¦Â production is inhibited by expression of RNF125 and enhanced by RNF125 knock-down. PMID: 18703349,15563593,15563593 A wide variety of paramyxoviruses target MDA5 but not RIG-I via their V protein and can specifically block MDA5-mediated IFN induction PMID: 18703349 Expression of DAK inhibits MDA5-mediated IFN¦Â and ISRE reporter gene activity, but not RIG-I, IPS-1 or TLR3 activity.

Go back
451.0, 487.0
17.0, 17.0

p42

p42

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e48 e5

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m49*m5*0.1

nodelay

--

true

0

false

PMID: 18703349 This residue of RIG-I, located in the CARD region, is a target for efficient TRIM25-induced ubiquitination that is essential for antiviral signaling.

Go back
1083.0, 655.0
17.0, 17.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016963 e63

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m1872*m64*0.1

nodelay

--

true

0

false

PMID:18703349 A biochemical approach has identified TNF receptor-associated factor 3 (TRAF3) as a DUBA interacting protein.

Go back
821.0, 589.0
19.0, 19.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016963 e21

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m1872*m21*0.1

nodelay

--

true

0

false

PMID: 18703349,16858409 TRAF3 directly associates with IPS-1 to induce IFNs in RLR signaling by linking TBK1/IKKepsilon kinases

Go back
494.0, 714.0
19.0, 19.0

p44

p45

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e19 MO000016963

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m19*m1872*0.1

nodelay

--

true

0

false

PMID: 18703349,16858409 TRAF3 directly associates with IPS-1 to induce IFNs in RLR signaling by linking TBK1/IKKepsilon kinases

Go back
1010.0, 782.0
19.0, 19.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e5 e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m5*m66*0.1

nodelay

--

true

0

false

PMID: 18703349,18516301 In addition, RIG-I and the G protein were shown to co-precipitate in co-expression studies as well as in hMPV infected cells

Go back
934.0, 386.0
19.0, 19.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e67 e13

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m68*m13*0.1

nodelay

--

true

0

false

PMID: 18703349,15563593 MDA5 was isolated in a screen for immunoprecipitated host cell proteins that interact with the V protein of parainfluenza virus 5 (PIV5)

Go back
1054.0, 1118.0
19.0, 19.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e69 MO000008179

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m70*m1055*0.1

nodelay

--

true

0

false

PMID: 18703349,9971827,9781815 NS1 has been demonstrated to inactivate several immune effectors, including the downregulation of cellular mRNA processing,interaction and blocking of PKR and s well as RNA sequestration from 2¡ì5¡ì-OAS activation.

Go back
1014.0, 1510.0
19.0, 19.0

p49

p49

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e73 e71 e69

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c139 : 1

m74*m72*0.1

nodelay

--

true

0

false

PMID: 18703349,10933707,11090154 IFN production is highly elevated in cells infected with NS1 deficient influenza A strains compared to cells infected with wild-type virus , and overexpression of NS1 can block IFN production by other viruses or PRR ligands

Go back
586.0, 1106.0
19.0, 19.0

p5

p5

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e15

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 18703349 Moreover, it was observed that LGP2 mRNA and protein are inducible by dsRNA or IFN treatments as well as virus infection, consistent with LGP2 functioning as a negative feedback regulator.

Go back
1047.0, 943.0
17.0, 17.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e69 e19

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m70*m19*0.1

nodelay

--

true

0

false

PMID: 18703349 For example, antiviral signaling induced by ectopic expression of IPS-1 is also inhibited by NS1 and both RIG-I and NS1 co-fractionate with IPS-1 in an insoluble cell fraction

Go back
306.0, 954.0
19.0, 19.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000041169 e49

e76 e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c149 : 1

m19042*m63*0.1

nodelay

--

true

0

false

PMID: 18703349 CYLD associates with the CARD domain of RIG-I and removes K63-linked ubiquitin from the RIG-I CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25.

Go back
305.0, 869.0
21.0, 21.0

p52

p52

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytoplasm

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c150 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 18703349 CYLD associates with the CARD domain of RIG-I and removes K63-linked ubiquitin from the RIG-I CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25.

Go back
777.0, 513.0
19.0, 19.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e13 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m13*m79*0.1

nodelay

--

true

0

false

PMID: 18703349 In immunoprecipitation experiments, DAK associates with MDA5 but not RIG-I, and the CARD domain-containing fragment of MDA5 is sufficient for the association.

Go back
329.0, 1101.0
17.0, 17.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000041169 MO000019331 MO000016608

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m19042*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 18703349 Immunoprecipitation experiments show that CYLD coprecipitates not only with RIG-I but also with TBK1 and IKKepsilon.

Go back
273.0, 1229.0
21.0, 21.0

p55

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e72

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 18703349 Interestingly, TBK1 or IKKepsilon but not RIG-I specifically precipitates two species of CYLD in size, suggesting phosphorylation of CYLD by these kinases.

Go back
1021.0, 457.0
21.0, 21.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e81 MO000094908

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m82*m68199*0.1

nodelay

--

true

0

false

PMID: 18703349 Intriguingly, association between endogenous NLRX1 and IPS-1 is observed and the interaction is mediated by the CARD-like domain of IPS-1 and a putative nucleotide-binding domain (NBD) of NLRX1

Go back
1154.0, 346.0
19.0, 19.0

p57

p57

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

MO000000289 e81

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c167 : 1
stoichiometry:c166 : 1

m230*m82*0.1

nodelay

--

true

0

false

PMID: 180703349,18219313 NLRX1 synergistically potentiates ROS production induced by TNFalpha, Shigella infection and double-stranded RNA treatment, resulting in amplified NF-¦ÊB-dependent and JUN amino-terminal kinases-dependent signaling

Go back
1158.0, 450.0
19.0, 19.0

p57

p58

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

e83 e81 e16

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m84*m82*m16*0.1

nodelay

--

true

0

false

PMID: 180703349,18219313 NLRX1 synergistically potentiates ROS production induced by TNFalpha, Shigella infection and double-stranded RNA treatment, resulting in amplified NF-¦ÊB-dependent and JUN amino-terminal kinases-dependent signaling

Go back
1150.0, 562.0
19.0, 19.0

p57

p59

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

e84 e81

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c172 : 1
stoichiometry:c173 : 1

m85*m82*0.1

nodelay

--

true

0

false

PMID: 180703349,18219313 NLRX1 synergistically potentiates ROS production induced by TNFalpha, Shigella infection and double-stranded RNA treatment, resulting in amplified NF-¦ÊB-dependent and JUN amino-terminal kinases-dependent signaling

Go back
478.0, 1330.0
19.0, 19.0

p4

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 18703349 Moreover, it was observed that LGP2 mRNA and protein are inducible by dsRNA or IFN treatments as well as virus infection, consistent with LGP2 functioning as a negative feedback regulator.

Go back
1050.0, 1194.0
19.0, 19.0

p60

p60

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

e85 e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m86*m87*0.1

nodelay

--

true

0

false

PMID: 18703349,12702807 The NS3/4A protease function was known to be essential for proper posttranslational cleavage of the hepatitis C virus polyprotein when it was also identified as responsible for inhibition of IRF3 phosphorylation

Go back
958.0, 1474.0
19.0, 19.0

p61

p61

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

e85 MO000041125

e88 e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m86*m18998*0.1

nodelay

--

true

0

false

PMID: 18703349,15710891 Sequence alignments of known NS3/4A specific cleavage sites in components of TLR3 signaling revealed a potential cleavage site in TRIF/TICAM-1 (Toll-IL-1 receptor domain-containing adaptor inducing IFNbeta), an adaptor molecule in the TLR3 signaling pathway. In vitro cleavage assays confirmed the predicted cleavage of TRIF into two fragments, both incapable of IFNbeta induction

Go back
682.0, 1190.0
20.0, 20.0

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18703349,16127453,16177806,16125763,16153868 Alternatively, it was found that LGP2 can suppress IFN¦Â promoter activity induced by non-RNA activators, including expression of the constitutively active RIG-I N-terminal CARD fragment or the signaling adaptor molecule IPS-1/MAVS/CARDIF/VISA from plasmid vectors.

Go back
754.0, 1242.0
20.0, 20.0

p7

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18703349,16127453,16177806,16125763,16153868 Alternatively, it was found that LGP2 can suppress IFN¦Â promoter activity induced by non-RNA activators, including expression of the constitutively active RIG-I N-terminal CARD fragment or the signaling adaptor molecule IPS-1/MAVS/CARDIF/VISA from plasmid vectors.

Go back
385.0, 773.0
22.0, 22.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m14*m19*0.1

nodelay

--

true

0

false

PMID: 18703349, 17020950 Mechanistic experiments found that LGP2 co-immunoprecipitates with the adaptor protein, IPS-1/MAVS/CARDIF/VISA, and exhibits competitive binding with the downstream kinase, IKKi/IKK¦Å for a common site in IPS-1

Go back
287.0, 370.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.0, 417.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
370.0, 710.4323358529394

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
514.0, 575.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 705.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
361.0, 617.9427765863886

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 610.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
466.0, 744.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.0, 809.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
407.7560975609756, 1232.8048780487804

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
79.93592715917114, 1175.0104751972858

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
405.4737070194212, 1097.0

c109

c109

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
520.0, 1297.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0, 1188.9851692431132

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.33847594618584, 958.0

c111

c111

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
80.0, 1172.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
235.0, 506.542576049781

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
429.0, 417.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 504.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1045.0, 665.4204706649821

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.0, 608.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.5813190393827, 604.5541342218241

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 608.9337572912799

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 1132.7946763151153

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 590.006034118021

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.4404466988269, 595.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 611.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.9562130931914, 669.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 674.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
435.0, 411.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.5251193663807, 797.7152492559105

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.0, 801.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.51557855175173, 726.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
462.7776850813911, 710.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
599.0, 928.5853562238041

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.5563772276438, 881.0

c130

c130

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
960.1554175279994, 365.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
591.0, 399.5557278121116

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.0, 398.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
459.61002603777894, 435.0

c134

c134

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1033.0, 1072.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1075.6499055497527, 1083.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
966.9929180023743, 1124.3365439158895

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
878.0, 1517.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1033.0, 1520.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.80057819045663, 1343.775099967487

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1038.1951888828146, 1195.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1024.0365281571528, 1072.0

c141

c141

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1030.0, 967.7658265556952

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 609.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 939.49689686312

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
255.0, 979.7165612572172

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
322.8272045497486, 594.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
259.65728152681294, 854.1150749703452

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
259.0, 840.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 973.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.0, 1349.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.0, 890.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.0, 471.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.8446454055273, 526.5689290811055

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.0, 458.998959620257

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.67558477710287, 451.0

c154

c154

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
258.0, 1073.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.50185868341066, 530.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.3351279824151, 614.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
307.87008539214537, 1118.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.758472741024, 1166.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.0, 921.0

c16

c16

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
277.91699286388103, 1250.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1047.6568542494924, 483.65685424949237

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.0, 471.4310835055999

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.7031504823708, 478.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.98283223215583, 501.37019914978373

c164

c164

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1180.9667174647866, 341.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1108.9103926934927, 347.1940215386404

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1109.0, 372.6127771244042

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1184.9870761335258, 453.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1110.0, 475.2179589656599

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.3915208483891, 1210.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1093.0, 352.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.91392667263, 550.0

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1110.0, 544.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1092.4316205732891, 359.62149731926456

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
989.0, 1204.3929676735984

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1070.6889582922297, 1219.4817952863177

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 1213.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.5399219206134, 792.090112722408

c177

c177

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
968.2498780190218, 1218.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
920.0, 1500.3783632201423

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 921.0

c18

c18

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
960.3897804297072, 1493.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
973.0, 1493.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.9546849639746, 1262.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 421.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
387.3400013724057, 417.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 481.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.1277928696519, 508.63243290472644

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.5777087639997, 509.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.0, 619.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.0, 795.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.0, 677.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.0, 565.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.0, 582.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 770.488448574556

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 404.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
414.2190671612076, 792.4474728892297

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.0, 752.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 564.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.631634032896, 661.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
277.0, 564.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.7628641043821, 714.2736014210102

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.94028500029066, 713.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.8647679165176, 664.9054034939506

c37

c37

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
818.0, 994.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.0, 1330.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
257.0, 458.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.0, 1040.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.0, 1305.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 1135.745561058369

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
816.0, 1002.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
538.0, 530.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.0, 613.8646187432906

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.0, 604.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
574.9287423733235, 614.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.0, 524.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
674.0, 606.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 496.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.0, 650.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.0, 723.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.0, 797.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.0, 783.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.7487994155043, 791.9058736678188

c54

c54

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
756.0, 833.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 897.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.0, 1004.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.0, 1132.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.0, 1220.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.0, 505.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.0, 1288.365296055314

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 1281.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.0, 824.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.0, 824.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.0, 833.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
862.0, 888.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 896.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0, 842.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.0, 764.9560436233712

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.2953720414008, 717.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 362.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 748.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.0, 948.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 957.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.2767660458304, 552.3239548604411

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 563.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.0, 522.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
674.0, 544.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.2044130909167, 500.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.4246907579123, 465.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0431289826962, 476.7347025773501

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
502.0, 387.32098068646155

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.7188942614009, 400.8131557336407

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.0, 384.3674279466493

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.5731992484011, 366.57811038243443

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.9867657322549, 457.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
591.0, 468.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.0, 404.7972783164867

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.0, 500.64931856704817

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.9195959492894, 458.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 492.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
257.52709929494983, 898.7097557461819

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0, 386.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
225.0, 909.0703033307765

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 902.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.0, 936.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.0, 941.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 417.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 992.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
422.6535459155622, 1002.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.0, 883.1808595010745

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
503.5296867331132, 481.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.4576496910791, 476.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back