1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18775672.csml convertedTime:2009.07.01.11:21

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title New insights into NF-kappaB regulation and function.
Authors Sun SC, Ley SC.
Affiliation Department of Immunology, MD Anderson Cancer Center, University of Texas,Houston, TX 77030, USA. ssun@mdanderson.org
Abstract NF-kappaB (nuclear factor-kappaB) transcription factors have multiple criticalroles in the regulation of immune responses. In unstimulated cells, NF-kappaBproteins are sequestered in the cytoplasm by IkappaB inhibitory proteins.Various immune stimuli induce the IkappaB kinase (IKK) to phosphorylateIkappaBs, triggering their ubiquitination and proteasomal degradation, whichpermits nuclear translocation of associated NF-kappaB subunits and activation ofNF-kappaB target genes. Recent studies have highlighted the importance ofdynamic ubiquitination-deubiquitination events in regulating this canonicalNF-kappaB signaling pathway. Ubiquitination additionally plays critical roles inactivation of the noncanonical pathway that regulates NF-kappaB viasignal-induced processing of NF-kappaB2 p100. New research has also identifiedseveral novel regulatory proteins that control the transcriptional activity ofnuclear NF-kappaB.
PMID 18775672
Model Abstract

Entity

G010329:TNF-alpha G010389:IL-1beta MO000000011:ERK MO000000065:RIP1 MO000000192:c-Rel MO000000194:RelB:p100 MO000000199:p50:p50:p105{p} MO000000203:NIK MO000000209:TRAF2 MO000000210:IKK MO000000212:TRAF6 MO000000213:IRAK MO000000214:IL-1 MO000000233:IkappaB-alpha MO000000238:Bcl-3{ub} MO000000254:p50:RelA-p65:IkappaB-alpha{p} MO000000289:TNF-alpha MO000002521:CD28 MO000016591:A20 MO000016632:p50:RelA-p65 MO000016882:LPS MO000016963:TRAF3 MO000017004:SOCS-1 MO000017443:TGFbeta1 MO000017450:Smad3 MO000017458:Smad4{active} MO000017700:PIAS1 MO000017949:RIP2 MO000019013:MSK1 MO000019394:TLR4 MO000020461:Nod2 MO000023571:HDACs MO000038234:Itch MO000038325:Ubc13:Uev1 MO000038724:p50:RelA-p65:IkappaB-alpha MO000041169:CYLD MO000064816:TRAF7 MO000069621:RPS3 e1: e10:p50:RelA-p65{p} e100:ABIN-3:k63 ubiquitinated protein e101:A20:TAX1BP1:RIP1{ub} e102:A20:TAX1BP1:RIP1 e103:A20:TAX1BP1:TRAF6{ub] e104:SCF ubiquitin E3 ligase e105:A20:TAX1BP1:TRAF6 e106:synthetic c-IAP antagonist e107:c-IAP1{ub} e108:c-IAP2{ub} e109:p50:p50:HDACs e11:IL-1:IL-1R e110:p52:p52 e111:p52:p52:HDACs e112:MSK2 e113:p300/CBP e114:p300/CBP{p} e115:p50:RelaA{p}:p300/CBP{p} e116:p50:RelaA{p}{Ac}:p300/CBP{p} e117:CDK1:CyclinT1 e118:p50:RelaA{p}{Ac}:p300/CBP{p}:CDK1:Cyclin T1 e119:p50:p52 e12:TNF e120:p52:p52 e121:p52:RelB e122:p50:RelA-p65{p} e123:p50:p50 e124:IKappaB-alpha e125:p50:RelA-p65{p}{ub} e126:PDLIM2 e127:proteosome degradants e128:c-Rel{ub} e129:P-TEFB e13:TNFR e130::RelA-p65{p}:P-TEFB e131:IL-8 e132:Smad3{active} e133:Smad4 e134:PKA{active} e135:p300/CBP{active} e136:p50:RelA-p65{p}{Ac} e137:CoMMD1 e138:ECS:COMMD1 e139:p65-RelA:p50:SOCS-1 e14:IL-1R e140:p50{ub}:RelA-p65{p} e141:PIAS1{p} e142:DNA e143:p50:RelA-p65{p}:promoter e144:RelA-p65:RelA-p65 e145:RelA-p65:relA-p65 e146:E2F1 e147:E2F1:p50:relA-p65{p} e148:Il-1beta e149:E2F1:p50:RelA-p65{p}:Il-1beta e15:IKK{active} e150:TNF e151:E2F1:p50:relA-p65{p]:TNF e152:CCL3 e153:E2F1:p50:relA-p65{p}:CCL3 e154:TNF e155:CCL3 e16:p50:RelA-p65:IkappaB-alpha{p}{ub} e17:Proteosome degradants e18:p50:RelA-p65{p} e19:LT alphabeta:receptor e2: e20:CD40L:receptor e21:BAFF e22:NIK{active} e23:IKK-alpha e24:IKK-alpha{active} e25:RelB:p100{p} e26:RelB:p100{p}{ub} e27:p52:RelB e28:p52:RelB e29:p105:TPL-2 e3: e30:p50:p50 e31:p50:p50:p105 e32:p105{p}:TPL-2 e33:TPL-2{active} e34:ERK{active} e35:p50:p50 e36:Target genes e37:TCR e38:TCR:CD28 e39:Carma1:Bcl10:MALT1 e4: e40:Carma1:Bcl10:MALT1:Ubc13:Uev1 e41:IKK-alpha:IKK-beta:Nemo{ub} e42:Carma1:Bcl10{ub}:MALT1{ub}:Ubc13:Uev1 e43:Carma1:Bcl10{ub}:MALT1{ub}:Ubc13:Uev1:IK{Kub}:TAK1{active}:TAK2:TAB1 e44:TAK1:TAK2:TAB1 e45:Carma1:Bcl10{ub}:MALT1{ub}:Ubc13:Uev1:IKK{ub}{p}:TAK1{active}:TAK2:TAB1 e46:IKK-alpha:IKK-beta:Nemo{ub}:CYLD e47:TRAF2{ub} e48:TRAF6{ub} e49:RIP1{ub} e5:LPS:TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TNF:TNFR e60: e61: e62: e63:RIP1:TAK1:TAB1:TAB2:IKK e64:RIP1:TAK1{active}:TAB1:TAB2:IKK{active} e65:DNA damaging agents e66:TRAF7{ub} e67:Bcl-3 e68:Bcl-3{ub} e69:p50:p52 e7: e70:p50:p52{active} e71:RIP2{ub} e72:TAX1BP1 e73:A20:TAX1BP1 e74:A20:TAX1BP1:Itch e75:A20{p} e78:TRAF2:TRAF3 e79:c-IAP1 e8:ECS e80:TRAF2:TRAF3:c-IAP1 e81:TRAF2:TRAF3:c-IAP1:NIK e82:c-IAP2 e83:TRAF2:TRAF3:c-IAP2 e84:TRAF2:TRAF3:c-IAP2:NIK e85:TRAF2:TRAF3:c-IAP2:NIK{ub} e86:TRAF2:TRAF3:c-IAP1:NIK{ub} e87:TWEAK e88:TRAF2:TRAF3:NIK{ub} e89:c-IAP2:NIK{ub} e9:PKA e90:c-IAP2:NIK{ub} e91:IRAK:TRAF6 e92:IRAK{ub}:TRAF6 e93:IRAK{ub}:TRAF6:IKK e94:ABIN-1 e95:k63 ubiquitinated protein e96:ABIN-1:k63 ubiquitinated protein e97:ABIN-2 e98:ABIN-2:k63 ubiquitinated protein e99:ABIN-3

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p125 p126 p127 p128 p129 p13 p130 p131 p132 p133 p134 p135 p136 p137 p138 p139 p14 p140 p141 p142 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
918.0, 1282.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
977.0, 1697.0
22.0, 22.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p140

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
968.0, 708.0
24.0, 24.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
1171.0, 579.0
18.0, 18.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

p43 p44 p59

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
809.0, 1573.0
22.0, 22.0

c-Rel

--

MO000000192

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p115 p116

true true true true

csml-variable:Double

m165

10

false

infinite

0

unit false false false
TRANSPATHMO000000192

--

Go back
319.0, 595.0
34.0, 34.0

RelB:p100

--

MO000000194

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m167

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
802.0, 542.0
20.0, 20.0

p50:p50:p105{p}

--

MO000000199

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

p21

true true true true

csml-variable:Double

m171

10

false

infinite

0

unit false false false
TRANSPATHMO000000199

--

Go back
433.0, 337.0
22.0, 22.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12 p13 p68 p71

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
914.0, 286.0
20.0, 20.0

TRAF2

--

MO000000209

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p38 p69

true true true true

csml-variable:Double

m180

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000209

--

Go back
670.0, 290.0
36.0, 36.0

IKK

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37 p58

p4 p5 p6 p31 p40 p41 p44 p46 p47 p77 p85

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
427.0, 395.0
18.0, 18.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p39 p42 p83

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1238.0, 282.0
20.0, 20.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
641.0, 45.0
22.0, 22.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
506.0, 898.0
20.0, 20.0

IkappaB-alpha

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

p111

--

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
587.0, 699.0
26.0, 26.0

Bcl-3{ub}

--

MO000000238

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p53

true true true true

csml-variable:Double

m204

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000238

--

Go back
660.0, 612.0
24.0, 24.0

p50:RelA-p65:IkappaB-alpha{p}

--

MO000000254

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7 p35

p8

true true true true

csml-variable:Double

m208

10

false

infinite

0

unit false false false
TRANSPATHMO000000254

--

Go back
1492.0, 1096.0
24.0, 24.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
990.0, 178.0
20.0, 20.0

CD28

--

MO000002521

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m387

10

false

infinite

0

unit false false false
InterProIPR001092
TRANSPATHMO000002521

--

Go back
807.0, 895.0
18.0, 18.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57 p58 p59 p61 p63

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
556.0, 828.0
23.5, 23.5

p50:RelA-p65

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p98 p99 p100 p111 p118 p129

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
463.0, 87.0
25.0, 25.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
417.0, 737.0
22.0, 22.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
371.0, 1015.0
18.0, 18.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p129

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
1498.0, 1626.0
20.0, 20.0

TGFbeta1

--

MO000017443

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p119 p122

true true true true

csml-variable:Double

m2269

10

false

infinite

0

unit false false false
InterProIPR002400
TRANSPATHMO000017443

--

Go back
1363.0, 1559.0
18.0, 18.0

Smad3

--

MO000017450

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p119

true true true true

csml-variable:Double

m2276

10

false

infinite

0

unit false false false
TRANSPATHMO000017450

--

Go back
1254.0, 1726.0
20.0, 20.0

Smad4{active}

--

MO000017458

cso30:c:Protein

cso30:i:CC_CellComponent

--

p122

p124

true true true true

csml-variable:Double

m2280

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000017458

--

Go back
1338.0, 306.0
19.0, 19.0

PIAS1

--

MO000017700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p131 p132

true true true true

csml-variable:Double

m2460

10

false

infinite

0

unit false false false
InterProIPR004181
TRANSPATHMO000017700

--

Go back
1222.0, 1010.0
20.0, 20.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

--

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
501.0, 697.0
22.0, 22.0

MSK1

--

MO000019013

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p99

true true true true

csml-variable:Double

m3621

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019013

--

Go back
589.0, 173.0
21.0, 21.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
450.0, 462.0
20.0, 20.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
600.0, 1336.0
16.5, 16.5

HDACs

--

MO000023571

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p95 p96

true true true true

csml-variable:Double

m7346

10

false

infinite

0

unit false false false
TRANSPATHMO000023571

--

Go back
1131.0, 1043.0
18.0, 18.0

Itch

--

MO000038234

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m16459

10

false

infinite

0

unit false false false
TRANSPATHMO000038234

--

Go back
1138.0, 266.0
19.0, 19.0

Ubc13:Uev1

--

MO000038325

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m16540

10

false

infinite

0

unit false false false
TRANSPATHMO000038325

--

Go back
564.0, 552.0
24.0, 24.0

p50:RelA-p65:IkappaB-alpha

--

MO000038724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p35

true true true true

csml-variable:Double

m16910

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
827.0, 335.0
18.0, 18.0

CYLD

--

MO000041169

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p48 p49 p50 p51 p52

true true true true

csml-variable:Double

m19042

10

false

infinite

0

unit false false false
TRANSPATHMO000041169

--

Go back
339.0, 519.0
18.0, 18.0

TRAF7

--

MO000064816

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

--

true true true true

csml-variable:Double

m39686

10

false

infinite

0

unit false false false
TRANSPATHMO000064816

--

Go back
977.0, 1889.0
22.0, 22.0

RPS3

--

MO000069621

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p134 p135

true true true true

csml-variable:Double

m44464

10

false

infinite

0

unit false false false
TRANSPATHMO000069621

--

Go back
178.1992685923137, 150.44768447987175
1379.754502678844, 2003.403537889682

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
624.0, 916.0
23.5, 23.5

p50:RelA-p65{p}

--

e10

cso30:c:Protein

cso30:i:CC_CellComponent

--

p98 p99 p100 p118

p10

true true true true

csml-variable:Double

m10

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
1358.5, 988.0
19.261956340609895, 23.586068988501925

ABIN-3:k63 ubiquitinated protein

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

p88

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1132.5, 856.0
22.900715727656454, 31.954487061846212

A20:TAX1BP1:RIP1{ub}

--

e101

cso30:c:Complex

cso30:i:CC_Cytosol

--

p89

p56

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
1060.5, 748.0
22.900715727656454, 31.954487061846212

A20:TAX1BP1:RIP1

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
432.5, 584.0
23.47678473114333, 32.758304276013945

A20:TAX1BP1:TRAF6{ub]

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

p55

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
439.5, 683.0
16.54538136445965, 26.83034815858321

SCF ubiquitin E3 ligase

--

e104

cso30:c:Protein

cso30:i:CC_Cell

--

--

p16

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
668.5, 512.0
23.47678473114333, 32.758304276013945

A20:TAX1BP1:TRAF6

--

e105

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1518.0, 975.0
41.95962994112699, 23.777123633305298

synthetic c-IAP antagonist

--

e106

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p91 p93

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
1382.0, 1085.0
27.417774667599716, 21.02029391182645

c-IAP1{ub}

--

e107

cso30:c:Protein

cso30:i:CC_Cytosol

--

p91

p92

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1194.0, 1037.0
27.41777466759972, 21.020293911826457

c-IAP2{ub}

--

e108

cso30:c:Protein

cso30:i:CC_Cytosol

--

p93

p94

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
766.0, 1507.0
20.735294117647065, 34.55882352941176

p50:p50:HDACs

--

e109

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p95

p25 p26 p27 p97

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
641.5, 160.0
20.35628151721114, 39.399254549440904

IL-1:IL-1R

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p5

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
536.0, 1468.0
23.5, 23.5

p52:p52

--

e110

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p96 p107

true true true true

csml-variable:Double

m112

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
674.0, 1631.0
20.735294117647065, 34.55882352941176

p52:p52:HDACs

--

e111

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p96

p25 p26 p27 p97

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
708.0, 1023.0
15.01870907390084, 34.658559401309624

MSK2

--

e112

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p100

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
944.0, 1339.5
23.2, 17.4

p300/CBP

--

e113

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p101 p125

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
804.0, 1371.5
23.2, 17.4

p300/CBP{p}

--

e114

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

p101

p102

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
609.0, 1414.0
21.70588235294118, 36.1764705882353

p50:RelaA{p}:p300/CBP{p}

--

e115

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p102

p103

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
341.0, 1462.0
21.70588235294118, 36.1764705882353

p50:RelaA{p}{Ac}:p300/CBP{p}

--

e116

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p103

p104 p105

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
385.0, 1656.0
21.33149171270718, 23.70165745856353

CDK1:CyclinT1

--

e117

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

--

p104

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
561.0, 1542.0
21.70588235294118, 36.1764705882353

p50:RelaA{p}{Ac}:p300/CBP{p}:CDK1:Cyclin T1

--

e118

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p104

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
448.0, 1900.0
23.5, 23.5

p50:p52

--

e119

cso30:c:Protein

cso30:i:CC_CellComponent

--

p106

--

true true true true

csml-variable:Double

m121

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
858.0, 95.5
27.451669595782068, 17.843585237258345

TNF

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
528.0, 1928.0
23.5, 23.5

p52:p52

--

e120

cso30:c:Protein

cso30:i:CC_CellComponent

--

p107

--

true true true true

csml-variable:Double

m122

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
611.0, 1971.0
34.0, 34.0

p52:RelB

--

e121

cso30:c:Protein

cso30:i:CC_CellComponent

--

p108

--

true true true true

csml-variable:Double

m123

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
816.0, 1964.0
23.5, 23.5

p50:RelA-p65{p}

--

e122

cso30:c:Protein

cso30:i:CC_CellComponent

--

p109

--

true true true true

csml-variable:Double

m124

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
876.0, 1940.0
23.5, 23.5

p50:p50

--

e123

cso30:c:Protein

cso30:i:CC_CellComponent

--

p110

--

true true true true

csml-variable:Double

m125

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
707.0, 1153.0
42.71626297577854, 22.782006920415224

IKappaB-alpha

--

e124

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p111

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
480.0, 1752.0
23.5, 23.5

p50:RelA-p65{p}{ub}

--

e125

cso30:c:Protein

cso30:i:CC_CellComponent

--

p112 p113

p114

true true true true

csml-variable:Double

m127

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
707.5, 1987.0
16.649627691688472, 26.99939625679211

PDLIM2

--

e126

cso30:c:Protein

cso30:i:CC_Cell

--

--

p113

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
709.0, 1585.0
22.039058012636424, 21.304422745548536

proteosome degradants

--

e127

cso30:c:EntityBiological

cso30:i:CC_Nucleoplasm

--

p114 p117 p130

--

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
859.0, 1690.0
25.675297410776768, 19.68439468159552

c-Rel{ub}

--

e128

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p116

p117

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
449.0, 1235.5
22.720000000000006, 17.04

P-TEFB

--

e129

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p120

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
867.5, 165.0
24.42355008787347, 37.57469244288225

TNFR

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
459.0, 1425.0
18.000000000000004, 30.0

:RelA-p65{p}:P-TEFB

--

e130

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p120

p121

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
418.97231833910035, 1575.0519031141869
33.21799307958478, 17.716262975778545

IL-8

--

e131

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p121

--

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
1267.0, 1671.0
18.0, 18.0

Smad3{active}

--

e132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p119

p123

true true true true

csml-variable:Double

m134

10

false

infinite

0

unit false false false
TRANSPATHMO000017450

--

Go back
1258.0, 1786.0
20.0, 20.0

Smad4

--

e133

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p122

true true true true

csml-variable:Double

m135

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000017458

--

Go back
1136.5, 1715.0
15.852887905011068, 25.70738579190984

PKA{active}

--

e134

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

p123 p124

p125

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
852.0, 1487.5
23.2, 17.4

p300/CBP{active}

--

e135

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

p125

p126

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
988.0, 1476.0
23.5, 23.5

p50:RelA-p65{p}{Ac}

--

e136

cso30:c:Protein

cso30:i:CC_CellComponent

--

p126

--

true true true true

csml-variable:Double

m138

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
541.0, 1983.5
21.919999999999995, 16.44

CoMMD1

--

e137

cso30:c:Protein

cso30:i:CC_Cell

--

--

p128

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
352.5, 1886.0
23.017997000499918, 28.18530244959173

ECS:COMMD1

--

e138

cso30:c:Complex

cso30:i:CC_Cell

--

p128

p129

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
333.5, 1173.0
21.3303358414388, 29.763259313635533

p65-RelA:p50:SOCS-1

--

e139

cso30:c:Complex

cso30:i:CC_Cell

--

p129

--

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
707.5, 161.0
24.81195079086116, 38.17223198594024

IL-1R

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2 p39

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
732.0, 1200.0
23.5, 23.5

p50{ub}:RelA-p65{p}

--

e140

cso30:c:Protein

cso30:i:CC_CellComponent

--

p127

p130

true true true true

csml-variable:Double

m142

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
1391.0, 418.0
25.60975609756097, 20.48780487804878

PIAS1{p}

--

e141

cso30:c:Protein

cso30:i:CC_Cell

--

p131 p132

p133

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
775.0, 1621.5
58.503581851950116, 12.675776067922525

DNA

--

e142

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p133 p134 p135

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
906.0, 1411.5
60.0, 17.0

p50:RelA-p65{p}:promoter

--

e143

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p133 p134

--

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
616.0, 1812.0
23.5, 23.5

RelA-p65:RelA-p65

--

e144

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p135

true true true true

csml-variable:Double

m146

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
622.0, 1703.5
60.0, 17.0

RelA-p65:relA-p65

--

e145

cso30:c:Complex

cso30:i:CC_Nucleolus

--

p135

--

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
949.0, 1235.0
14.702525724976613, 33.928905519176794

E2F1

--

e146

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p136

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
996.5, 1375.0
23.650394567810615, 33.000550559735736

E2F1:p50:relA-p65{p}

--

e147

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p136

p137 p138 p139

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
1023.0, 1341.5
58.503581851950116, 12.675776067922525

Il-1beta

--

e148

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p137

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
1030.0, 1463.5
60.0, 17.0

E2F1:p50:RelA-p65{p}:Il-1beta

--

e149

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p137

p140

true true true true

csml-variable:Double

m151

0

false

infinite

0

unit false false false

--

Go back
634.0, 402.0
36.0, 36.0

IKK{active}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4 p5 p6 p77

p7 p19 p20 p63 p101

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
834.0, 1529.5
60.0, 13.0

TNF

--

e150

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p138

true true true true

csml-variable:Double

m152

0

false

infinite

0

unit false false false

--

Go back
1042.0, 1515.5
60.0, 17.0

E2F1:p50:relA-p65{p]:TNF

--

e151

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p138

p141

true true true true

csml-variable:Double

m153

0

false

infinite

0

unit false false false

--

Go back
866.0, 1565.5
60.0, 13.0

CCL3

--

e152

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p139

true true true true

csml-variable:Double

m154

0

false

infinite

0

unit false false false

--

Go back
1022.0, 1615.5
60.0, 17.0

E2F1:p50:relA-p65{p}:CCL3

--

e153

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p139

p142

true true true true

csml-variable:Double

m155

0

false

infinite

0

unit false false false

--

Go back
919.0, 1725.0
42.61245674740484, 22.726643598615922

TNF

--

e154

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p141

--

true true true true

csml-variable:Double

m156

0

false

infinite

0

unit false false false

--

Go back
856.0, 1781.0
55.7439446366782, 29.730103806228374

CCL3

--

e155

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p142

--

true true true true

csml-variable:Double

m157

0

false

infinite

0

unit false false false

--

Go back
644.0, 756.0
24.0, 24.0

p50:RelA-p65:IkappaB-alpha{p}{ub}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p9

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000254

--

Go back
832.0, 761.0
23.589890867317635, 22.80356117174038

Proteosome degradants

--

e17

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p9 p21 p22 p60 p73 p75 p76 p79 p80 p81 p92 p94

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
608.0, 1248.0
23.5, 23.5

p50:RelA-p65{p}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p26 p102 p109 p112 p113 p120 p126 p127 p133 p134 p136

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
230.5, 161.0
19.771760578820437, 38.26792370094279

LT alphabeta:receptor

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p11 p79 p80

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
178.1992685923137, 150.44768447987175
1379.754502678844, 2003.403537889682

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
338.5, 150.0
18.14733611050208, 35.12387634290726

CD40L:receptor

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p12 p81

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
435.5, 163.0
17.345319008989254, 33.571585178688885

BAFF

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
305.0, 377.0
22.0, 22.0

NIK{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p12 p13

p14

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
344.0, 436.0
24.0, 24.0

IKK-alpha

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
392.0, 492.0
24.0, 24.0

IKK-alpha{active}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p15

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
391.0, 627.0
34.0, 34.0

RelB:p100{p}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p16

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
387.0, 787.0
34.0, 34.0

RelB:p100{p}{ub}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p17

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
491.0, 851.0
34.0, 34.0

p52:RelB

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

p18

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
579.0, 1187.0
34.0, 34.0

p52:RelB

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p25 p108

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
908.0, 436.0
32.0, 32.0

p105:TPL-2

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000199

--

Go back
205.79435864589047, 178.04277453344858
1324.5643225716904, 1948.2133577825293

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
724.0, 904.0
23.5, 23.5

p50:p50

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p24

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
782.0, 406.0
20.0, 20.0

p50:p50:p105

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000199

--

Go back
852.0, 500.0
32.0, 32.0

p105{p}:TPL-2

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p22

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000199

--

Go back
985.0, 571.5
22.56, 16.919999999999998

TPL-2{active}

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
988.0, 876.0
24.0, 24.0

ERK{active}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p28

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
724.0, 1276.0
23.5, 23.5

p50:p50

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

p27 p95 p110

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
489.0, 1356.0
45.83044982698962, 24.442906574394463

Target genes

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p25 p26 p27 p97 p105 p115

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
922.5, 170.0
18.81341811006358, 36.41306730980049

TCR

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p29

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1069.5, 177.0
21.29087906037805, 29.708203340062393

TCR:CD28

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p30

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
995.5, 231.0
24.652596806753536, 34.39897228849331

Carma1:Bcl10:MALT1

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
256.8452752450082, 226.33418212720795
1222.4624893734567, 1851.6305425950106

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1202.0, 327.0
20.911764705882355, 34.852941176470594

Carma1:Bcl10:MALT1:Ubc13:Uev1

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31 p32

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1010.0, 406.0
36.0, 36.0

IKK-alpha:IKK-beta:Nemo{ub}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31 p40 p41 p46 p47

p33 p36 p58

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
1130.0, 459.0
20.911764705882355, 34.852941176470594

Carma1:Bcl10{ub}:MALT1{ub}:Ubc13:Uev1

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p33

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1273.0, 545.0
22.85294117647059, 38.08823529411766

Carma1:Bcl10{ub}:MALT1{ub}:Ubc13:Uev1:IK{Kub}:TAK1{active}:TAK2:TAB1

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
944.5, 488.0
22.38777757386676, 31.23875940539548

TAK1:TAK2:TAB1

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p33 p44

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1281.0, 637.0
22.85294117647059, 38.08823529411766

Carma1:Bcl10{ub}:MALT1{ub}:Ubc13:Uev1:IKK{ub}{p}:TAK1{active}:TAK2:TAB1

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1082.0, 664.0
19.676470588235293, 32.79411764705882

IKK-alpha:IKK-beta:Nemo{ub}:CYLD

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p37

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1190.0, 418.0
20.0, 20.0

TRAF2{ub}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p41 p43 p49

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000209

--

Go back
523.0, 443.0
18.0, 18.0

TRAF6{ub}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39 p42

p40 p48 p90

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1171.0, 679.0
18.0, 18.0

RIP1{ub}

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43 p59

p51 p60 p89

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
534.5, 162.0
21.076737557553166, 40.7936855952642

LPS:TLR4

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p4 p42 p83 p127 p132

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
310.1108653995071, 1125.2160181574523
827.1285067104724, 750.1146792700193

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
399.4469052304326, 1142.9926455609352
483.6468363260492, 727.0105310378842

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
320.89280124117096, 1135.2278157247106
805.5646350271466, 730.0910841355026

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
322.43307778997945, 1136.768092273521
802.4840819295274, 727.0105310378842

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
310.1108653995071, 1125.2160181574523
827.1285067104724, 750.1146792700193

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
310.1108653995071, 1125.2160181574523
827.1285067104724, 750.1146792700193

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
322.43307778997945, 1136.768092273521
802.4840819295274, 727.0105310378842

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
913.899272532667, 1433.2713279192667
51.674444438320585, 46.77897075469039

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
778.3549362374658, 1648.9100447525393
146.32627213686212, 132.46378319758082

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
310.1108653995071, 1125.2160181574523
827.1285067104724, 750.1146792700193

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
781.5, 159.0
21.831177373383028, 42.25389169041877

TNF:TNFR

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p6 p38 p115 p118 p131

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
505.0604004993952, 1458.5607833764298
26.19394446984383, 12.611899189184077

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
504.18571054945005, 1420.9491155287965
89.65571986935852, 161.38029576484516

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
541.7973783970847, 1525.911909522192
13.995039199119368, 13.995039199119377

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1250.0, 711.0
20.382352941176475, 33.97058823529413

RIP1:TAK1:TAB1:TAB2:IKK

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p45

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1090.0, 827.0
20.382352941176475, 33.97058823529413

RIP1:TAK1{active}:TAB1:TAB2:IKK{active}

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1198.0, 115.0
44.70984020185029, 25.335576114381833

DNA damaging agents

--

e65

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p47

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
495.0, 575.0
18.0, 18.0

TRAF7{ub}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000064816

--

Go back
503.0, 639.0
26.0, 26.0

Bcl-3

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p127

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000238

--

Go back
439.0, 1383.0
26.0, 26.0

Bcl-3{ub}

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

p54

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000238

--

Go back
368.0, 1388.0
23.5, 23.5

p50:p52

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p97 p106

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
255.58356315673086, 238.95663607610385
1288.6004408397062, 1825.913539787626

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
384.0, 1332.0
23.5, 23.5

p50:p52{active}

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

--

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
1186.0, 850.0
20.0, 20.0

RIP2{ub}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
1070.0, 947.5
27.289192996578794, 16.828335681223585

TAX1BP1

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p61

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1106.5, 1004.0
19.408931844692553, 23.766038993501088

A20:TAX1BP1

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

p62 p89 p90

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1060.5, 1125.0
22.20627638098734, 30.985501926959074

A20:TAX1BP1:Itch

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1307.0, 867.0
18.0, 18.0

A20{p}

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63

--

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
1326.5, 944.0
19.00066655557407, 23.26612231294784

TRAF2:TRAF3

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p69

p67 p70

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1212.5, 1175.0
15.912457234856108, 25.80398470517207

c-IAP1

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p67 p91

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
350.0, 1963.5
28.72610183135439, 17.714429462668544

ECS

--

e8

cso30:c:Protein

cso30:i:CC_Cell

--

--

p112 p128

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
1141.5, 1162.0
20.1071756285557, 28.056524132868418

TRAF2:TRAF3:c-IAP1

--

e80

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67 p75

p68

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1194.0, 1459.0
20.470588235294116, 34.11764705882353

TRAF2:TRAF3:c-IAP1:NIK

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p68

p74

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1164.5, 1235.0
15.912457234856108, 25.80398470517207

c-IAP2

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p70 p93

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1377.5, 1206.0
20.1071756285557, 28.056524132868418

TRAF2:TRAF3:c-IAP2

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p70 p73

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1258.0, 1247.0
20.470588235294116, 34.11764705882353

TRAF2:TRAF3:c-IAP2:NIK

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p71

p72

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
1358.0, 1423.0
20.470588235294116, 34.11764705882353

TRAF2:TRAF3:c-IAP2:NIK{ub}

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p72

p73 p78 p79 p81

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1174.0, 1555.0
20.470588235294116, 34.11764705882353

TRAF2:TRAF3:c-IAP1:NIK{ub}

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

p75 p76 p80

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1509.0, 1245.0
13.13376987839102, 30.30869971936389

TWEAK

--

e87

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p76 p78

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
921.5, 1094.0
20.1071756285557, 28.056524132868418

TRAF2:TRAF3:NIK{ub}

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p76 p78

p77

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
453.5, 976.0
20.111148141976333, 24.625895684052665

c-IAP2:NIK{ub}

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
780.5, 843.0
15.852887905011068, 25.70738579190984

PKA

--

e9

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p98 p123 p124

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
413.5, 872.0
20.111148141976333, 24.625895684052665

c-IAP2:NIK{ub}

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80 p81

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1322.5, 412.0
19.80903182802866, 24.255957340443263

IRAK:TRAF6

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p83

p84

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1378.5, 472.0
19.80903182802866, 24.255957340443263

IRAK{ub}:TRAF6

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

p84

p85

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1378.0, 535.0
20.911764705882355, 34.85294117647059

IRAK{ub}:TRAF6:IKK

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1333.0, 611.5
22.88, 17.160000000000004

ABIN-1

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p86

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1393.0, 740.0
30.293911826452067, 23.225332400279918

k63 ubiquitinated protein

--

e95

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p86 p87 p88

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
1294.5, 672.0
19.261956340609895, 23.586068988501925

ABIN-1:k63 ubiquitinated protein

--

e96

cso30:c:Complex

cso30:i:CC_Cytosol

--

p86

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1253.0, 787.5
22.88, 17.160000000000004

ABIN-2

--

e97

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p87

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1390.5, 844.0
19.261956340609895, 23.586068988501925

ABIN-2:k63 ubiquitinated protein

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p87

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1407.0, 926.5
25.759999999999998, 19.32

ABIN-3

--

e99

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p88

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
534.0, 90.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 18775672 This so-called canonical NF-KappaB pathway is stimulated by various immune receptors, such as the Toll-like receptors (TLRs), interleukin-1 receptor (IL-1R), tumor necrosis factor receptor (TNFR) and antigen receptors. PMID: 18775672 The canonical pathway is activated by a large number of agonists [e.g. tumor necrosis fator (TNF), interleukin 1 (IL-1) or microbial ligands such as lipopolysaccharide (LPS)] through the triggering of various cytokine receptors or TLRs and stimulate the IKappaB kinase (IKK) complex (IKK1-IKK2-NEMO) to phosphorylate IKappaB-alpha and promote its degradation.

Go back
666.0, 1078.0
19.0, 19.0

p10

p10

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e10

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c28 : 1

m10*0.1

nodelay

--

true

0

false

PMID: 18775672 Activated IKK phosphorylates IKappaB-alpha, predominantly via the action of IKK2, triggering its lysine-48?linked polyubiquitination and proteasomal degradation, releasing associated NF-KappaB subunits to translocate into the nucleus.

Go back
709.0, 957.0
21.0, 21.0

p98

p100

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

e112 MO000016632

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c288 : 1
stoichiometry:c289 : 1

m114*m1617*0.1

nodelay

--

true

0

false

PMID: 18775672 S276 can be phosphorylated by protein kinase A (PKA) and mitogen- and stress-activated protein kinases (MSKs) 1 and 2, inducing binding to CREB-binding protein (CBP) and p300 co-activator complexes, which acetylate adjacent histones and RelA to stimulate target gene transcription. PMID: 18775672 Figure 3

Go back
778.0, 1090.0
19.0, 19.0

p101

p101

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

e15 e113

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c290 : 1
stoichiometry:c291 : 1
stoichiometry:c292 : 1

m15*m115*0.1

nodelay

--

true

0

false

PMID: 18775672 IkappaB kinase 1 (IKK1)phosphorylation of CBP-p300 stimulates preferential binding to NF-KappaB complexes.

Go back
770.0, 1446.0
19.0, 19.0

p102

p102

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e114 e18

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c294 : 1
stoichiometry:c295 : 1

m116*m18*0.1

nodelay

--

true

0

false

PMID: 18775672 S276 can be phosphorylated by protein kinase A (PKA) and mitogen- and stress-activated protein kinases (MSKs) 1 and 2, inducing binding to CREB-binding protein (CBP) and p300 co-activator complexes, which acetylate adjacent histones and RelA to stimulate target gene transcription

Go back
462.0, 1466.0
19.0, 19.0

p103

p103

cso30:i:ME_Acetylation

cso30:i:CC_Nucleoplasm

--

e115

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c296 : 1
stoichiometry:c297 : 1

m117*0.1

nodelay

--

true

0

false

PMID: 18775672 S276 can be phosphorylated by protein kinase A (PKA) and mitogen- and stress-activated protein kinases (MSKs) 1 and 2, inducing binding to CREB-binding protein (CBP) and p300 co-activator complexes, which acetylate adjacent histones and RelA to stimulate target gene transcription

Go back
341.0, 1545.0
21.0, 21.0

p104

p104

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e116 e117

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c298 : 1
stoichiometry:c299 : 1
stoichiometry:c300 : 1

m118*m119*0.1

nodelay

--

true

0

false

PMID: 18775672 RelA S276 phosphorylation also triggers recruitment of a complex of CDK1 and cyclin T1, which promotes transcriptional elongation.

Go back
606.0, 1770.0
19.0, 19.0

p105

p105

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e116

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c302 : 1

m118*0.1

nodelay

--

true

0

false

PMID: 18775672 RelA S276 phosphorylation also triggers recruitment of a complex of CDK1 and cyclin T1, which promotes transcriptional elongation. PMID: 18775672 Figure 3

Go back
442.0, 1826.0
19.0, 19.0

p106

p106

cso30:i:ME_Translocation

cso30:i:CC_Cell_WithoutCellWall_

--

e69

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c304 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 18775672 NF-KappaB dimers can be transported back to the cytoplasm as a result of NF-KappaB?dependent IKappaBalpha resynthesis.

Go back
534.0, 1874.0
19.0, 19.0

p106

p107

cso30:i:ME_Translocation

cso30:i:CC_Cell_WithoutCellWall_

--

e110

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c305 : 1
stoichiometry:c306 : 1

m112*0.1

nodelay

--

true

0

false

PMID: 18775672 NF-KappaB dimers can be transported back to the cytoplasm as a result of NF-KappaB?dependent IKappaBalpha resynthesis.

Go back
622.0, 1894.0
19.0, 19.0

p106

p108

cso30:i:ME_Translocation

cso30:i:CC_Cell_WithoutCellWall_

--

e28

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c307 : 1
stoichiometry:c308 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 18775672 NF-KappaB dimers can be transported back to the cytoplasm as a result of NF-KappaB?dependent IKappaBalpha resynthesis.

Go back
682.0, 1902.0
19.0, 19.0

p106

p109

cso30:i:ME_Translocation

cso30:i:CC_Cell_WithoutCellWall_

--

e18

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c309 : 1
stoichiometry:c310 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18775672 NF-KappaB dimers can be transported back to the cytoplasm as a result of NF-KappaB?dependent IKappaBalpha resynthesis.

Go back
305.0, 293.0
21.0, 21.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e19 MO000000203

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m19*m174*0.1

nodelay

--

true

0

false

PMID:18775672 The p100-mediated pathway, often called the noncanonical NF-KappaB pathway, is triggered by a subset of TNF family members and sequentially activates NF-KappaB inducing kinase (NIK) and IKK1. PMID: 18775672 A limited number of agonists induce processing of p100 to p52 via activation of NF-KappaB?inducing kinase (NIK) and IKK1, resulting in the nuclear translocation of p52-RelB heterodimers. PMID: 18775672 Figure 1

Go back
802.0, 1910.0
19.0, 19.0

p106

p110

cso30:i:ME_Translocation

cso30:i:CC_Cell_WithoutCellWall_

--

e35

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c311 : 1
stoichiometry:c312 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 18775672 NF-KappaB dimers can be transported back to the cytoplasm as a result of NF-KappaB?dependent IKappaBalpha resynthesis.

Go back
546.0, 1046.0
19.0, 19.0

p111

p111

cso30:i:ME_Translation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000016632 e124

MO000000233

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c314 : 1
stoichiometry:c315 : 1

m1617*m126*0.1

nodelay

--

true

0

false

PMID: 18775672 NF-KappaB dimers can be transported back to the cytoplasm as a result of NF-KappaB?dependent IKappaBalpha resynthesis.

Go back
466.0, 1674.0
19.0, 19.0

p112

p112

cso30:i:ME_Ubiquitination

cso30:i:CC_Nucleoplasm

--

e8 e18

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c316 : 1
stoichiometry:c317 : 1
stoichiometry:c318 : 1

m8*m18*0.1

nodelay

--

true

0

false

PMID: 18775672 Alternatively, RelA can be ubiquitinated by ECSSOCS1 or PDLIM2 E3 ligases, triggering its degradation by the proteasome.

Go back
730.0, 1738.0
19.0, 19.0

p112

p113

cso30:i:ME_Ubiquitination

cso30:i:CC_Nucleoplasm

--

e126 e18

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c320 : 1
stoichiometry:c321 : 1

m128*m18*0.1

nodelay

--

true

0

false

PMID: 18775672 Alternatively, RelA can be ubiquitinated by ECSSOCS1 or PDLIM2 E3 ligases, triggering its degradation by the proteasome.

Go back
529.0, 1597.0
21.0, 21.0

p114

p114

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Nucleoplasm

--

e125

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c323 : 1

m127*0.1

nodelay

--

true

0

false

PMID: 18775672 Alternatively, RelA can be ubiquitinated by ECSSOCS1 or PDLIM2 E3 ligases, triggering its degradation by the proteasome.

Go back
650.0, 1514.0
20.0, 20.0

p115

p115

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000192 e6

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c324 : 1
stoichiometry:c326 : 1
stoichiometry:c325 : 1

m165*m6*0.1

nodelay

--

true

0

false

PMID: 18775672 c-Rel?mediated transcription is also turned off by ubiquitin-dependent proteolysis in stimulated cells

Go back
862.0, 1606.0
19.0, 19.0

p116

p116

cso30:i:ME_Ubiquitination

cso30:i:CC_Nucleoplasm

--

MO000000192

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c327 : 1
stoichiometry:c328 : 1

m165*0.1

nodelay

--

true

0

false

PMID: 18775672 c-Rel?mediated transcription is also turned off by ubiquitin-dependent proteolysis in stimulated cells

Go back
742.0, 1682.0
19.0, 19.0

p117

p117

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Nucleoplasm

--

e128

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c329 : 1
stoichiometry:c330 : 1

m130*0.1

nodelay

--

true

0

false

PMID: 18775672 c-Rel?mediated transcription is also turned off by ubiquitin-dependent proteolysis in stimulated cells

Go back
445.0, 917.0
19.0, 19.0

p118

p118

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

e6 MO000016632

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c331 : 1
stoichiometry:c332 : 1
stoichiometry:c333 : 1

m6*m1617*0.1

nodelay

--

true

0

false

PMID: 18775672 Binding of phospho-S276-RelA is primarily restricted to a subset of genes that are rapidly induced by TNF, such as the chemokine IL-8. PMID: 18775672 Induction of such genes involves the association of phospho-S276-RelA with the P-TEFb transcriptional elongation factor, a complex of CDK-9 (cyclin-dependent kinase-9) and cyclin T1, which controls Pol II recruitment and activation.

Go back
1381.0, 1625.0
21.0, 21.0

p119

p119

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000017443 MO000017450

e132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c339 : 1
stoichiometry:c340 : 1
stoichiometry:c341 : 1

m2269*m2276*0.1

nodelay

--

true

0

false

PMID: 18775672,17268554 For example, in epithelial cells, TGF-beta1 induces RelA acetylation on K221 via a Smad3 and 4?PKA?p300-dependent signaling pathway

Go back
357.0, 261.0
21.0, 21.0

p11

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000000203

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m20*m174*0.1

nodelay

--

true

0

false

PMID:18775672 The p100-mediated pathway, often called the noncanonical NF-KappaB pathway, is triggered by a subset of TNF family members and sequentially activates NF-KappaB inducing kinase (NIK) and IKK1. PMID: 18775672 A limited number of agonists induce processing of p100 to p52 via activation of NF-KappaB?inducing kinase (NIK) and IKK1, resulting in the nuclear translocation of p52-RelB heterodimers. PMID: 18775672 Figure 1

Go back
554.0, 1274.0
19.0, 19.0

p120

p120

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e18 e129

e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c334 : 1
stoichiometry:c335 : 1
stoichiometry:c336 : 1

m18*m131*0.1

nodelay

--

true

0

false

PMID: 18775672 Binding of phospho-S276-RelA is primarily restricted to a subset of genes that are rapidly induced by TNF, such as the chemokine IL-8. PMID: 18775672 Induction of such genes involves the association of phospho-S276-RelA with the P-TEFb transcriptional elongation factor, a complex of CDK-9 (cyclin-dependent kinase-9) and cyclin T1, which controls Pol II recruitment and activation.

Go back
441.0, 1509.0
21.0, 21.0

p121

p121

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e130

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c337 : 1
stoichiometry:c338 : 1

m132*0.1

nodelay

--

true

0

false

--

Go back
1317.0, 1725.0
21.0, 21.0

p119

p122

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000017443 e133

MO000017458

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c342 : 1
stoichiometry:c343 : 1
stoichiometry:c344 : 1

m2269*m135*0.1

nodelay

--

true

0

false

PMID: 18775672,17268554 For example, in epithelial cells, TGF-beta1 induces RelA acetylation on K221 via a Smad3 and 4?PKA?p300-dependent signaling pathway

Go back
1313.0, 1585.0
21.0, 21.0

p119

p123

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e132 e9

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c345 : 1
stoichiometry:c346 : 1
stoichiometry:c347 : 1

m134*m9*0.1

nodelay

--

true

0

false

PMID: 18775672,17268554 For example, in epithelial cells, TGF-beta1 induces RelA acetylation on K221 via a Smad3 and 4?PKA?p300-dependent signaling pathway

Go back
1193.0, 1621.0
21.0, 21.0

p119

p124

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000017458 e9

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c348 : 1
stoichiometry:c350 : 1
stoichiometry:c349 : 1

m2280*m9*0.1

nodelay

--

true

0

false

PMID: 18775672,17268554 For example, in epithelial cells, TGF-beta1 induces RelA acetylation on K221 via a Smad3 and 4?PKA?p300-dependent signaling pathway

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825.0, 1337.0
21.0, 21.0

p119

p125

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e134 e113

e135

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c351 : 1
stoichiometry:c352 : 1
stoichiometry:c353 : 1

m136*m115*0.1

nodelay

--

true

0

false

PMID: 18775672,17268554 For example, in epithelial cells, TGF-beta1 induces RelA acetylation on K221 via a Smad3 and 4?PKA?p300-dependent signaling pathway

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858.0, 1302.0
19.0, 19.0

p126

p126

cso30:i:ME_Acetylation

cso30:i:CC_Nucleoplasm

--

e135 e18

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c354 : 1
stoichiometry:c355 : 1
stoichiometry:c356 : 1

m137*m18*0.1

nodelay

--

true

0

false

PMID: 18775672,17268554 For example, in epithelial cells, TGF-¦Â1 induces RelA acetylation on K221 via a Smad3 and 4?PKA?p300-dependent signaling pathway

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889.0, 1225.0
22.0, 22.0

p127

p127

cso30:i:ME_Ubiquitination

cso30:i:CC_Nucleoplasm

--

e18 e5 e67

e140

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c364 : 1
stoichiometry:c366 : 1
stoichiometry:c369 : 1
stoichiometry:c365 : 1

m18*m5*0.1

nodelay

--

true

0

false

PMID: 18775672,17673665 LPS stimulation of macrophages also increases the ubiquitination and proteolysis of p50 by the proteasome PMID: 18775672 This is inhibited by BCL3, which blocks p50 ubiquitination and stabilizes a p50 complex that inhibits gene transcription.

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438.0, 1950.0
19.0, 19.0

p128

p128

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e137 e8

e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c357 : 1
stoichiometry:c358 : 1
stoichiometry:c359 : 1

m139*m8*0.1

nodelay

--

true

0

false

PMID: 18775672,17183367 COMMD1 interacts with ECSSOCS1 and increases the interaction between SOCS1 and RelA

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478.0, 1010.0
19.0, 19.0

p129

p129

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000016632 MO000017004 e138

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c360 : 1
stoichiometry:c361 : 1
stoichiometry:c362 : 1
stoichiometry:c363 : 1

m1617*m1906*m140*0.1

nodelay

--

true

0

false

PMID: 18775672,17183367 COMMD1 interacts with ECSSOCS1 and increases the interaction between SOCS1 and RelA

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433.0, 261.0
21.0, 21.0

p11

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e21 MO000000203

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m21*m174*0.1

nodelay

--

true

0

false

PMID:18775672 The p100-mediated pathway, often called the noncanonical NF-KappaB pathway, is triggered by a subset of TNF family members and sequentially activates NF-KappaB inducing kinase (NIK) and IKK1. PMID: 18775672 A limited number of agonists induce processing of p100 to p52 via activation of NF-KappaB?inducing kinase (NIK) and IKK1, resulting in the nuclear translocation of p52-RelB heterodimers. PMID: 18775672 Figure 1

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771.0, 1291.0
17.0, 17.0

p130

p130

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Nucleoplasm

--

e140

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c367 : 1
stoichiometry:c368 : 1

m142*0.1

nodelay

--

true

0

false

PMID: 18775672,17673665 LPS stimulation of macrophages also increases the ubiquitination and proteolysis of p50 by the proteasome

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1387.0, 351.0
17.0, 17.0

p131

p131

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

MO000017700 e6

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c370 : 1
stoichiometry:c372 : 1
stoichiometry:c371 : 1

m2460*m6*0.1

nodelay

--

true

0

false

PMID: 18775672,17540171 After TNF or LPS stimulation, PIAS1 is rapidly phosphorylated on S90, which is required for PIAS1 to block the promoter binding of RelA

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1423.0, 295.0
17.0, 17.0

p131

p132

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

e5 MO000017700

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c373 : 1
stoichiometry:c374 : 1
stoichiometry:c375 : 1

m5*m2460*0.1

nodelay

--

true

0

false

PMID: 18775672,17540171 After TNF or LPS stimulation, PIAS1 is rapidly phosphorylated on S90, which is required for PIAS1 to block the promoter binding of RelA

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794.0, 1174.0
19.0, 19.0

p133

p133

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e142 e18 e141

e143

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c377 : 1
stoichiometry:c376 : 1
stoichiometry:c379 : 1
stoichiometry:c378 : 1

m144*m18*0.1

nodelay

--

true

0

false

PMID: 18775672,17540171 After TNF or LPS stimulation, PIAS1 is rapidly phosphorylated on S90, which is required for PIAS1 to block the promoter binding of RelA

Go back
798.0, 1766.0
19.0, 19.0

p134

p134

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e18 e142 MO000069621

e143

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c380 : 1
stoichiometry:c381 : 1
stoichiometry:c383 : 1
stoichiometry:c382 : 1

m18*m144*m44464*0.1

nodelay

--

true

0

false

PMID: 18775672,18045535 A partner of RelA, the ribosomal protein S3 (RPS3), was identified by affinity purification and shown to substantially increase the DNA binding activity of RelA-RelA homodimers and p50-RelA heterodimers.

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738.0, 1806.0
19.0, 19.0

p134

p135

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e144 e142 MO000069621

e145

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c384 : 1
stoichiometry:c385 : 1
stoichiometry:c387 : 1
stoichiometry:c386 : 1

m146*m144*m44464*0.1

nodelay

--

true

0

false

PMID: 18775672,18045535 A partner of RelA, the ribosomal protein S3 (RPS3), was identified by affinity purification and shown to substantially increase the DNA binding activity of RelA-RelA homodimers and p50-RelA heterodimers.

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993.0, 1289.0
21.0, 21.0

p136

p136

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e146 e18

e147

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c388 : 1
stoichiometry:c389 : 1
stoichiometry:c390 : 1

m148*m18*0.1

nodelay

--

true

0

false

PMID: 18775672 E2F1 is rapidly recruited to the promoters of these genes via its physical interaction with p50-RelA heterodimers in LPS-stimulated cells.

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1055.0, 1403.0
17.0, 17.0

p137

p137

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e147 e148

e149

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c391 : 1
stoichiometry:c392 : 1
stoichiometry:c393 : 1

m149*m150*0.1

nodelay

--

true

0

false

PMID: 18775672 RNAi knockdown revealed a requirement for E2F1 for the transcriptional activation of several LPS-inducible NF-KappaB target genes, including IL-1beta, TNF and CCL3.

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943.0, 1527.0
17.0, 17.0

p137

p138

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e147 e150

e151

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c394 : 1
stoichiometry:c395 : 1
stoichiometry:c396 : 1

m149*m152*0.1

nodelay

--

true

0

false

PMID: 18775672 RNAi knockdown revealed a requirement for E2F1 for the transcriptional activation of several LPS-inducible NF-KappaB target genes, including IL-1beta, TNF and CCL3.

Go back
995.0, 1567.0
17.0, 17.0

p137

p139

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e152 e147

e153

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c397 : 1
stoichiometry:c398 : 1
stoichiometry:c399 : 1

m154*m149*0.1

nodelay

--

true

0

false

PMID: 18775672 RNAi knockdown revealed a requirement for E2F1 for the transcriptional activation of several LPS-inducible NF-KappaB target genes, including IL-1beta, TNF and CCL3.

Go back
393.0, 381.0
21.0, 21.0

p11

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m22*m23*0.1

nodelay

--

true

0

false

PMID:18775672 The p100-mediated pathway, often called the noncanonical NF-KappaB pathway, is triggered by a subset of TNF family members and sequentially activates NF-KappaB inducing kinase (NIK) and IKK1. PMID: 18775672 A limited number of agonists induce processing of p100 to p52 via activation of NF-KappaB?inducing kinase (NIK) and IKK1, resulting in the nuclear translocation of p52-RelB heterodimers.

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974.0, 1638.0
19.0, 19.0

p140

p140

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e149

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c400 : 1
stoichiometry:c401 : 1

m151*0.1

nodelay

--

true

0

false

PMID: 18775672 RNAi knockdown revealed a requirement for E2F1 for the transcriptional activation of several LPS-inducible NF-KappaB target genes, including IL-1beta, TNF and CCL3. PMID: 18775672 E2F1 is rapidly recruited to the promoters of these genes via its physical interaction with p50-RelA heterodimers in LPS-stimulated cells.

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898.0, 1646.0
19.0, 19.0

p140

p141

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e151

e154

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c402 : 1
stoichiometry:c403 : 1

m153*0.1

nodelay

--

true

0

false

PMID: 18775672 RNAi knockdown revealed a requirement for E2F1 for the transcriptional activation of several LPS-inducible NF-KappaB target genes, including IL-1beta, TNF and CCL3. PMID: 18775672 E2F1 is rapidly recruited to the promoters of these genes via its physical interaction with p50-RelA heterodimers in LPS-stimulated cells.

Go back
870.0, 1734.0
19.0, 19.0

p140

p142

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e153

e155

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c404 : 1
stoichiometry:c405 : 1

m155*0.1

nodelay

--

true

0

false

PMID: 18775672 RNAi knockdown revealed a requirement for E2F1 for the transcriptional activation of several LPS-inducible NF-KappaB target genes, including IL-1beta, TNF and CCL3. PMID: 18775672 E2F1 is rapidly recruited to the promoters of these genes via its physical interaction with p50-RelA heterodimers in LPS-stimulated cells.

Go back
373.0, 545.0
21.0, 21.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000194 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c41 : 1
stoichiometry:c43 : 1

m167*m24*0.1

nodelay

--

true

0

false

PMID: 18775672,15214841 IKK1 phosphorylates p100, triggering its polyubiquitination and subsequent partial proteolysis by the proteasome to produce p52, which translocates into the nucleus predominantly in association with RelB PMID: 18775672,11239468,16303288 IKK1 phosphorylates p100 at two C-terminal serines, which promotes p100 ubiquitination by the SCFbetaTrCP ubiquitin E3 ligase, partial proteolysis by the proteasome and subsequent nuclear translocation of p52-RelB complexes

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330.0, 730.0
19.0, 19.0

p16

p16

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e25 e104

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c233 : 1
stoichiometry:c45 : 1

m25*m106*0.1

nodelay

--

true

0

false

PMID: 18775672,15214841 IKK1 phosphorylates p100, triggering its polyubiquitination and subsequent partial proteolysis by the proteasome to produce p52, which translocates into the nucleus predominantly in association with RelB PMID: 18775672,11239468,16303288 IKK1 phosphorylates p100 at two C-terminal serines, which promotes p100 ubiquitination by the SCFbetaTrCP ubiquitin E3 ligase, partial proteolysis by the proteasome and subsequent nuclear translocation of p52-RelB complexes

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494.0, 766.0
19.0, 19.0

p17

p17

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 18775672,15214841 IKK1 phosphorylates p100, triggering its polyubiquitination and subsequent partial proteolysis by the proteasome to produce p52, which translocates into the nucleus predominantly in association with RelB PMID: 18775672,11239468,16303288 IKK1 phosphorylates p100 at two C-terminal serines, which promotes p100 ubiquitination by the SCFbetaTrCP ubiquitin E3 ligase, partial proteolysis by the proteasome and subsequent nuclear translocation of p52-RelB complexes

Go back
518.0, 1094.0
19.0, 19.0

p18

p18

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 18775672,15214841 IKK1 phosphorylates p100, triggering its polyubiquitination and subsequent partial proteolysis by the proteasome to produce p52, which translocates into the nucleus predominantly in association with RelB PMID: 18775672,11239468,16303288 IKK1 phosphorylates p100 at two C-terminal serines, which promotes p100 ubiquitination by the SCFbetaTrCP ubiquitin E3 ligase, partial proteolysis by the proteasome and subsequent nuclear translocation of p52-RelB complexes

Go back
677.0, 485.0
21.0, 21.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e15 e31

MO000000199

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c56 : 1
stoichiometry:c52 : 1

m15*m31*0.1

nodelay

--

true

0

false

PMID: 18775672 However, p105 is phosphorylated by IKK after activation of the canonical pathway, targeting it for complete degradation by the proteasome to release associated NF-KappaB subunits. PMID: 18775672 By contrast, the canonical IKK complex triggers p105 proteolysis, which releases associated Rel subunits and also facilitates activation of the p105-associated TPL-2 MEK kinase, which triggers extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase activation

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643.0, 91.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000214 e14

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m185*m14*0.1

nodelay

--

true

0

false

PMID: 18775672 The canonical pathway is activated by a large number of agonists [e.g. tumor necrosis fator (TNF), interleukin 1 (IL-1) or microbial ligands such as lipopolysaccharide (LPS)] through the triggering of various cytokine receptors or TLRs and stimulate the IKappaB kinase (IKK) complex (IKK1-IKK2-NEMO) to phosphorylate IKappaB-alpha and promote its degradation. PMID: 18775672 This so-called canonical NF-KappaB pathway is stimulated by various immune receptors, such as the Toll-like receptors (TLRs), interleukin-1 receptor (IL-1R), tumor necrosis factor receptor (TNFR) and antigen receptors.

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809.0, 433.0
21.0, 21.0

p19

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e15 e29

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m15*m29*0.1

nodelay

--

true

0

false

PMID: 18775672 However, p105 is phosphorylated by IKK after activation of the canonical pathway, targeting it for complete degradation by the proteasome to release associated NF-KappaB subunits. PMID: 18775672 By contrast, the canonical IKK complex triggers p105 proteolysis, which releases associated Rel subunits and also facilitates activation of the p105-associated TPL-2 MEK kinase, which triggers extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase activation

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715.0, 591.0
18.0, 18.0

p21

p21

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000000199

e30 e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m171*0.1

nodelay

--

true

0

false

PMID: 18775672 By contrast, the canonical IKK complex triggers p105 proteolysis, which releases associated Rel subunits and also facilitates activation of the p105-associated TPL-2 MEK kinase, which triggers extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase activation PMID: 18775672 However, p105 is phosphorylated by IKK after activation of the canonical pathway, targeting it for complete degradation by the proteasome to release associated NF-KappaB subunits

Go back
827.0, 563.0
18.0, 18.0

p21

p22

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e32

e17 e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18775672 By contrast, the canonical IKK complex triggers p105 proteolysis, which releases associated Rel subunits and also facilitates activation of the p105-associated TPL-2 MEK kinase, which triggers extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase activation PMID: 18775672 However, p105 is phosphorylated by IKK after activation of the canonical pathway, targeting it for complete degradation by the proteasome to release associated NF-KappaB subunits

Go back
890.0, 714.0
19.0, 19.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33 MO000000011

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m33*m34*0.1

nodelay

--

true

0

false

PMID: 18775672 By contrast, the canonical IKK complex triggers p105 proteolysis, which releases associated Rel subunits and also facilitates activation of the p105-associated TPL-2 MEK kinase, which triggers extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase activation

Go back
730.0, 1082.0
19.0, 19.0

p24

p24

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e30

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure1

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506.0, 1254.0
19.0, 19.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e28 e111 e109

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c69 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure1 PMID: 18775672 In unstimulated cells, homodimers of p50 and p52 actively repress transcription of NF-¦ÊB target genes to which they are bound by recruitment of histone deacetylases (HDAC).

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682.0, 1302.0
19.0, 19.0

p25

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18 e109 e111

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c280 : 1
stoichiometry:c281 : 1
stoichiometry:c71 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure1

Go back
717.0, 1353.0
21.0, 21.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35 e109 e111

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c276 : 1
stoichiometry:c277 : 1
stoichiometry:c73 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure1 PMID: 18775672 In unstimulated cells, homodimers of p50 and p52 actively repress transcription of NF-¦ÊB target genes to which they are bound by recruitment of histone deacetylases (HDAC).

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1026.0, 1066.0
19.0, 19.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e34

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1

m93309*m35*0.1

nodelay

--

true

0

false

PMID: 18775672,15214841 Tpl-2 is a mitogen-activated protein (MAP) 3-kinase that mediates TLR-stimulated activation of extracellular signal-regulated kinase (ERK) and production of TNF-alpha in macrophages, thereby regulating inflammatory responses

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991.0, 115.0
17.0, 17.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000002521

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m38*m387*0.1

nodelay

--

true

0

false

PMID: 18775672 Ligation of TCR and the costimulatory molecule CD28 triggers the association of the intermediate CBM signaling complex, composed of Carma1, Bcl10 and MALT1, with the Ubc13-Uve1 ubiquitin conjugating enzyme heterodimer.

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782.0, 94.0
19.0, 19.0

p2

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 e12

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m13*m12*0.1

nodelay

--

true

0

false

PMID: 18775672 The canonical pathway is activated by a large number of agonists [e.g. tumor necrosis fator (TNF), interleukin 1 (IL-1) or microbial ligands such as lipopolysaccharide (LPS)] through the triggering of various cytokine receptors or TLRs and stimulate the IKappaB kinase (IKK) complex (IKK1-IKK2-NEMO) to phosphorylate IKappaB-alpha and promote its degradation. PMID: 18775672 This so-called canonical NF-KappaB pathway is stimulated by various immune receptors, such as the Toll-like receptors (TLRs), interleukin-1 receptor (IL-1R), tumor necrosis factor receptor (TNFR) and antigen receptors.

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1059.0, 267.0
17.0, 17.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 e39 MO000038325

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m39*m40*m16540*0.1

nodelay

--

true

0

false

PMID: 18775672 Ligation of TCR and the costimulatory molecule CD28 triggers the association of the intermediate CBM signaling complex, composed of Carma1, Bcl10 and MALT1, with the Ubc13-Uve1 ubiquitin conjugating enzyme heterodimer PMID: 18775672,17948050 TCR stimulation similarly promotes recruitment of TAK1 and IKK to the paracaspase MALT1, which is conjugated with K63-linked ubiquitin chains

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1058.0, 334.0
19.0, 19.0

p31

p31

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e40 MO000000210

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m41*m181*0.1

nodelay

--

true

0

false

PMID: 18775672 This mediates K63-linked ubiquitination of NEMO, Bcl10 and MALT1, promoting the interaction of the CBM complex with IKK and transforming growth factor beta (TGF-beta)-activated kinase 1 (TAK1), which is a required step for the activation of IKK. PMID: 18775672 For example, positions K399 and K285 of NEMO are conjugated with K63-linked polyubiquitin chains in cells stimulated via the TCR (T-cell receptor) and NOD2 (nucleotide oligomerization domain), respectively.

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1246.0, 402.0
19.0, 19.0

p31

p32

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e40

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 18775672 This mediates K63-linked ubiquitination of NEMO, Bcl10 and MALT1, promoting the interaction of the CBM complex with IKK and transforming growth factor beta (TGF-beta)-activated kinase 1 (TAK1), which is a required step for the activation of IKK.

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1050.0, 478.0
19.0, 19.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 e42 e44

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c92 : 1
stoichiometry:c91 : 1

m42*m43*m45*0.1

nodelay

--

true

0

false

PMID: 18775672 This mediates K63-linked ubiquitination of NEMO, Bcl10 and MALT1, promoting the interaction of the CBM complex with IKK and transforming growth factor beta (TGF-beta)-activated kinase 1 (TAK1), which is a required step for the activation of IKK. PMID: 18775672 It is generally thought that assembly of ubiquitin-dependent signaling complexes both activates TAK1 and allows TAK1 to efficiently phosphorylate and activate IKK.

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1254.0, 594.0
19.0, 19.0

p34

p34

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m44*0.1

nodelay

--

true

0

false

--

Go back
1091.0, 615.0
17.0, 17.0

p35

p35

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e45 MO000038724

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m46*m16910*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure 1b

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902.0, 342.0
19.0, 19.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041169 e41

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m19042*m42*0.1

nodelay

--

true

0

false

PMID: 18775672,18535581 CYLD physically interacts with and deubiquitinates NEMO, thereby negatively regulating NF-KappaB activation

Go back
829.0, 697.0
21.0, 21.0

p37

p37

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

e46

MO000000210

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 18775672,18535581 CYLD physically interacts with and deubiquitinates NEMO, thereby negatively regulating NF-KappaB activation

Go back
994.0, 286.0
19.0, 19.0

p38

p38

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e6 MO000000209

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m6*m180*0.1

nodelay

--

true

0

false

PMID: 18775672 On receptor ligation, TRAF2 and TRAF6 undergo self-ubiquitination and induce the ubiquitination of target proteins involved in IKK activation, such as NF-¦ÊB essential modulator (NEMO) and several signaling adaptors.

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542.0, 366.0
19.0, 19.0

p38

p39

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e14 MO000000212

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m14*m183*0.1

nodelay

--

true

0

false

PMID: 18775672 On receptor ligation, TRAF2 and TRAF6 undergo self-ubiquitination and induce the ubiquitination of target proteins involved in IKK activation, such as NF-¦ÊB essential modulator (NEMO) and several signaling adaptors.

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529.0, 297.0
21.0, 21.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e5 MO000000210

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m5*m181*0.1

nodelay

--

true

0

false

PMID: 18775672 On ligand engagement, each of these triggers signal transduction events that lead to the activation of the IKappaB kinase (IKK) complex, composed of two catalytic subunits (IKK1 and IKK2) and a regulatory subunit, NEMO (NF-KappaB essential modulator). PMID: 18775672 By contrast, the canonical IKK complex triggers p105 proteolysis, which releases associated Rel subunits and also facilitates activation of the p105-associated TPL-2 MEK kinase, which triggers extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase activation PMID: 18775672 However, p105 is phosphorylated by IKK after activation of the canonical pathway, targeting it for complete degradation by the proteasome to release associated NF-KappaB subunits.

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606.0, 354.0
19.0, 19.0

p38

p40

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e48 MO000000210

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m49*m181*0.1

nodelay

--

true

0

false

PMID: 18775672 On receptor ligation, TRAF2 and TRAF6 undergo self-ubiquitination and induce the ubiquitination of target proteins involved in IKK activation, such as NF-¦ÊB essential modulator (NEMO) and several signaling adaptors.

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834.0, 366.0
19.0, 19.0

p38

p41

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e47 MO000000210

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m48*m181*0.1

nodelay

--

true

0

false

PMID: 18775672 On receptor ligation, TRAF2 and TRAF6 undergo self-ubiquitination and induce the ubiquitination of target proteins involved in IKK activation, such as NF-¦ÊB essential modulator (NEMO) and several signaling adaptors.

Go back
494.0, 302.0
19.0, 19.0

p38

p42

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e5 MO000000212

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m5*m183*0.1

nodelay

--

true

0

false

PMID: 18775672 On receptor ligation, TRAF2 and TRAF6 undergo self-ubiquitination and induce the ubiquitination of target proteins involved in IKK activation, such as NF-¦ÊB essential modulator (NEMO) and several signaling adaptors.

Go back
1211.0, 507.0
17.0, 17.0

p43

p43

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e47 MO000000065

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m48*m63*0.1

nodelay

--

true

0

false

PMID: 18775672 In TNF-stimulated cells, TRAF2 mediates the K63 ubiquitination of an adaptor kinase, RIP1, which in turn recruits TAK1 and IKK complexes and mediates their catalytic activation.

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1146.5, 767.0
18.5, 18.5

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 e44 MO000000210

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m63*m45*m181*0.1

nodelay

--

true

0

false

PMID: 18775672 In TNF-stimulated cells, TRAF2 mediates the K63 ubiquitination of an adaptor kinase, RIP1, which in turn recruits TAK1 and IKK complexes and mediates their catalytic activation.

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1243.0, 843.0
17.0, 17.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m65*0.1

nodelay

--

true

0

false

indirect

Go back
561.0, 449.0
21.0, 21.0

p46

p46

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000020461 MO000000210

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c127 : 1
stoichiometry:c129 : 1

m4947*m181*0.1

nodelay

--

true

0

false

PMID: 18775672 For example, positions K399 and K285 of NEMO are conjugated with K63-linked polyubiquitin chains in cells stimulated via the TCR (T-cell receptor) and NOD2 (nucleotide oligomerization domain), respectively.

Go back
834.0, 262.0
19.0, 19.0

p47

p47

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e65 MO000000210

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m67*m181*0.1

nodelay

--

true

0

false

PMID: 18775672 By contrast, DNA damaging agents induce NEMO monoubiquitination at positions K277 and K309.

Go back
521.0, 537.0
21.0, 21.0

p48

p48

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

MO000041169 e48

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m19042*m49*0.1

nodelay

--

true

0

false

PMID: 18775672,18535581 CYLD also removes K63-linked ubiquitin from TRAF2, TRAF6, TRAF7, RIP1, TAK1 and Bcl-3

Go back
953.0, 317.0
21.0, 21.0

p48

p49

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

MO000041169 e47

MO000000209

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m19042*m48*0.1

nodelay

--

true

0

false

PMID: 18775672,18535581 CYLD also removes K63-linked ubiquitin from TRAF2, TRAF6, TRAF7, RIP1, TAK1 and Bcl-3

Go back
601.0, 261.0
21.0, 21.0

p4

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e11 MO000000210

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m11*m181*0.1

nodelay

--

true

0

false

PMID: 18775672 On ligand engagement, each of these triggers signal transduction events that lead to the activation of the IKappaB kinase (IKK) complex, composed of two catalytic subunits (IKK1 and IKK2) and a regulatory subunit, NEMO (NF-KappaB essential modulator).

Go back
473.0, 509.0
21.0, 21.0

p48

p50

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

MO000041169 e66

MO000064816

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m19042*m68*0.1

nodelay

--

true

0

false

PMID: 18775672,18535581 CYLD also removes K63-linked ubiquitin from TRAF2, TRAF6, TRAF7, RIP1, TAK1 and Bcl-3

Go back
893.0, 497.0
21.0, 21.0

p48

p51

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

MO000041169 e49

MO000000065

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m19042*m64*0.1

nodelay

--

true

0

false

PMID: 18775672,18535581 CYLD also removes K63-linked ubiquitin from TRAF2, TRAF6, TRAF7, RIP1, TAK1 and Bcl-3

Go back
589.0, 641.0
21.0, 21.0

p48

p52

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

MO000041169 MO000000238

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m19042*m204*0.1

nodelay

--

true

0

false

PMID: 18775672,18535581 CYLD also removes K63-linked ubiquitin from TRAF2, TRAF6, TRAF7, RIP1, TAK1 and Bcl-3

Go back
610.0, 1062.0
19.0, 19.0

p53

p53

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000000238

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m204*0.1

nodelay

--

true

0

false

PMID: 18775672,16713561 Bcl-3 ubiquitination, by contrast, seems to promote its translocation into the nucleus, where it functions as a transcriptional coactivator of p50- and p52-containing complexes

Go back
450.0, 1278.0
19.0, 19.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e68 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m70*m71*0.1

nodelay

--

true

0

false

PMID: 18775672,16713561 Bcl-3 ubiquitination, by contrast, seems to promote its translocation into the nucleus, where it functions as a transcriptional coactivator of p50- and p52-containing complexes

Go back
701.0, 561.0
22.0, 22.0

p55

p55

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

e103

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c255 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 18775672,15334086,18342009,14748687,15258597,16684768 Like CYLD, A20 can deubiquitinate several NF-¦ÊB regulatory proteins, including TRAF6, RIP1, RIP2 and NEMO

Go back
873.0, 737.0
22.0, 22.0

p55

p56

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

e101

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c160 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 18775672,15334086,18342009,14748687,15258597,16684768 Like CYLD, A20 can deubiquitinate several NF-¦ÊB regulatory proteins, including TRAF6, RIP1, RIP2 and NEMO

Go back
1161.0, 929.0
22.0, 22.0

p55

p57

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

MO000016591 e71

MO000017949

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c159 : 1

m1585*m73*0.1

nodelay

--

true

0

false

PMID: 18775672,15334086,18342009,14748687,15258597,16684768 Like CYLD, A20 can deubiquitinate several NF-¦ÊB regulatory proteins, including TRAF6, RIP1, RIP2 and NEMO

Go back
765.0, 669.0
22.0, 22.0

p55

p58

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

MO000016591 e41

MO000000210

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m1585*m42*0.1

nodelay

--

true

0

false

PMID: 18775672,15334086,18342009,14748687,15258597,16684768 Like CYLD, A20 can deubiquitinate several NF-¦ÊB regulatory proteins, including TRAF6, RIP1, RIP2 and NEMO

Go back
1053.0, 793.0
21.0, 21.0

p59

p59

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000065 MO000016591

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c165 : 1
stoichiometry:c167 : 1

m63*m1585*0.1

nodelay

--

true

0

false

PMID: 18775672 A20 removes K63-linked ubiquitin chains from RIP1 and concurrently stimulates conjugation of K48-linked ubiquitin chains to RIP1, which targets it for proteasomal degradation.

Go back
761.0, 253.0
21.0, 21.0

p4

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 MO000000210

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m6*m181*0.1

nodelay

--

true

0

false

PMID: 18775672 On ligand engagement, each of these triggers signal transduction events that lead to the activation of the IKappaB kinase (IKK) complex, composed of two catalytic subunits (IKK1 and IKK2) and a regulatory subunit, NEMO (NF-KappaB essential modulator). PMID: 18775672 By contrast, the canonical IKK complex triggers p105 proteolysis, which releases associated Rel subunits and also facilitates activation of the p105-associated TPL-2 MEK kinase, which triggers extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase activation PMID: 18775672 However, p105 is phosphorylated by IKK after activation of the canonical pathway, targeting it for complete degradation by the proteasome to release associated NF-KappaB subunits.

Go back
1153.0, 809.0
21.0, 21.0

p60

p60

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e49

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18775672 A20 removes K63-linked ubiquitin chains from RIP1 and concurrently stimulates conjugation of K48-linked ubiquitin chains to RIP1, which targets it for proteasomal degradation.

Go back
935.0, 1031.0
17.0, 17.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016591 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m1585*m74*0.1

nodelay

--

true

0

false

PMID: 18775672,18246070 However, it is uncertain whether the E3 ligase activity associated with A20 is intrinsic, because Itch E3 ligase can be recruited to A20 via TAX1BP1 (TAX1-binding protein 1), an adaptor that was originally found to associate with the Tax protein encoded by human T-cell leukemia virus type I PMID: 18775672,17703191,18239685 TAX1BP1 interacts with A20 and mediates the recruitment of A20 to K63-ubiquitinated RIP1 and TRAF6

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1071.0, 1091.0
17.0, 17.0

p61

p62

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e73 MO000038234

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m75*m16459*0.1

nodelay

--

true

0

false

PMID: 18775672,18246070 However, it is uncertain whether the E3 ligase activity associated with A20 is intrinsic, because Itch E3 ligase can be recruited to A20 via TAX1BP1 (TAX1-binding protein 1), an adaptor that was originally found to associate with the Tax protein encoded by human T-cell leukemia virus type I

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1254.0, 906.0
19.0, 19.0

p63

p63

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e15 MO000016591

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m15*m1585*0.1

nodelay

--

true

0

false

PMID: 18775672,17709380 The DUB catalytic activity of A20 might also be positively regulated through its phosphorylation by IKK2

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1270.0, 1090.0
19.0, 19.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e79 e78

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m81*m80*0.1

nodelay

--

true

0

false

PMID: 18775672 TNF receptor?associated factor 2 (TRAF2) and TRAF3 physically associate with cellular inhibitor of apoptosis 1 (c-IAP1; or c-IAP2) and NIK, respectively, and form a NIK-degradation complex via TRAF2-TRAF3 dimerization.

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1102.0, 1194.0
19.0, 19.0

p67

p68

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000203 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m174*m82*0.1

nodelay

--

true

0

false

PMID: 18775672 TNF receptor?associated factor 2 (TRAF2) and TRAF3 physically associate with cellular inhibitor of apoptosis 1 (c-IAP1; or c-IAP2) and NIK, respectively, and form a NIK-degradation complex via TRAF2-TRAF3 dimerization.

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637.0, 1005.0
21.0, 21.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 MO000000209

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m1872*m180*0.1

nodelay

--

true

0

false

PMID: 18775672 Because TRAF2 dimerizes with TRAF3 and physically interacts with c-IAPs and NIK, an attractive model is that these two TRAF members bridge NIK with its ubiquitin ligases c-IAP1 and 2, and thus both serve as essential components of the NIK-degradation complex.

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643.0, 535.0
17.0, 17.0

p7

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e15 MO000038724

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m15*m16910*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure 1 PMID: 18775672 Activated IKK phosphorylates IKappaB-alpha, predominantly via the action of IKK2, triggering its lysine-48?linked polyubiquitination and proteasomal degradation, releasing associated NF-KappaB subunits to translocate into the nucleus. PMID: 18775672 The canonical pathway is activated by a large number of agonists [e.g. tumor necrosis fator (TNF), interleukin 1 (IL-1) or microbial ligands such as lipopolysaccharide (LPS)] through the triggering of various cytokine receptors or TLRs and stimulate the IKappaB kinase (IKK) complex (IKK1-IKK2-NEMO) to phosphorylate IKappaB-alpha and promote its degradation.

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1194.0, 1098.0
19.0, 19.0

p67

p70

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e82 e78

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m84*m80*0.1

nodelay

--

true

0

false

PMID: 18775672 TNF receptor?associated factor 2 (TRAF2) and TRAF3 physically associate with cellular inhibitor of apoptosis 1 (c-IAP1; or c-IAP2) and NIK, respectively, and form a NIK-degradation complex via TRAF2-TRAF3 dimerization.

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1182.0, 1318.0
19.0, 19.0

p67

p71

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000203

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m174*0.1

nodelay

--

true

0

false

PMID: 18775672 TNF receptor?associated factor 2 (TRAF2) and TRAF3 physically associate with cellular inhibitor of apoptosis 1 (c-IAP1; or c-IAP2) and NIK, respectively, and form a NIK-degradation complex via TRAF2-TRAF3 dimerization.

Go back
1310.0, 1282.0
19.0, 19.0

p72

p72

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 18775672 TNF receptor?associated factor 2 (TRAF2) and TRAF3 physically associate with cellular inhibitor of apoptosis 1 (c-IAP1; or c-IAP2) and NIK, respectively, and form a NIK-degradation complex via TRAF2-TRAF3 dimerization.

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1402.0, 1502.0
19.0, 19.0

p73

p73

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e85

e17 e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m87*0.1

nodelay

--

true

0

false

PMID: 18775672 TNF receptor?associated factor 2 (TRAF2) and TRAF3 physically associate with cellular inhibitor of apoptosis 1 (c-IAP1; or c-IAP2) and NIK, respectively, and form a NIK-degradation complex via TRAF2-TRAF3 dimerization.

Go back
1246.0, 1582.0
19.0, 19.0

p72

p74

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e81

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1

m83*0.1

nodelay

--

true

0

false

PMID: 18775672 TNF receptor?associated factor 2 (TRAF2) and TRAF3 physically associate with cellular inhibitor of apoptosis 1 (c-IAP1; or c-IAP2) and NIK, respectively, and form a NIK-degradation complex via TRAF2-TRAF3 dimerization.

Go back
1274.0, 1494.0
19.0, 19.0

p73

p75

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e86

e17 e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m88*0.1

nodelay

--

true

0

false

PMID: 18775672 TNF receptor?associated factor 2 (TRAF2) and TRAF3 physically associate with cellular inhibitor of apoptosis 1 (c-IAP1; or c-IAP2) and NIK, respectively, and form a NIK-degradation complex via TRAF2-TRAF3 dimerization.

Go back
1090.0, 1278.0
19.0, 19.0

p76

p76

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e87 e86

e17 e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c214 : 1

m89*m88*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure2 PMID: 18775672,15084608,18022362,16148124 For example, degradation of c-IAP1 is associated with induction of p100 processing by a TNF family member, TWEAK (TNF-like weak inducer of apoptosis) , whereas TRAF2 and TRAF3 proteolysis is induced by several other agonists of the noncanonical pathway

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462.0, 638.0
19.0, 19.0

p77

p77

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e88 MO000000210

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1
stoichiometry:c217 : 1

m90*m181*0.1

nodelay

--

true

0

false

--

Go back
1250.0, 1378.0
19.0, 19.0

p76

p78

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e87 e85

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1

m89*m87*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure2 PMID: 18775672,15084608,18022362,16148124 For example, degradation of c-IAP1 is associated with induction of p100 processing by a TNF family member, TWEAK (TNF-like weak inducer of apoptosis) , whereas TRAF2 and TRAF3 proteolysis is induced by several other agonists of the noncanonical pathway

Go back
417.0, 1109.0
21.0, 21.0

p79

p79

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e19 e85

e89 e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c228 : 1

m19*m87*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure2 PMID: 18775672,15084608,18022362,16148124 For example, degradation of c-IAP1 is associated with induction of p100 processing by a TNF family member, TWEAK (TNF-like weak inducer of apoptosis) , whereas TRAF2 and TRAF3 proteolysis is induced by several other agonists of the noncanonical pathway

Go back
645.0, 685.0
21.0, 21.0

p8

p8

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000254

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m208*0.1

nodelay

--

true

0

false

--

Go back
329.0, 1065.0
21.0, 21.0

p79

p80

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e86 e19

e90 e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1
stoichiometry:c229 : 1

m88*m19*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure2 PMID: 18775672,15084608,18022362,16148124 For example, degradation of c-IAP1 is associated with induction of p100 processing by a TNF family member, TWEAK (TNF-like weak inducer of apoptosis) , whereas TRAF2 and TRAF3 proteolysis is induced by several other agonists of the noncanonical pathway

Go back
605.0, 777.0
21.0, 21.0

p79

p81

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e20 e85

e90 e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c230 : 1
stoichiometry:c231 : 1
stoichiometry:c232 : 1

m20*m87*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure2 PMID: 18775672,15084608,18022362,16148124 For example, degradation of c-IAP1 is associated with induction of p100 processing by a TNF family member, TWEAK (TNF-like weak inducer of apoptosis) , whereas TRAF2 and TRAF3 proteolysis is induced by several other agonists of the noncanonical pathway

Go back
1323.0, 347.0
17.0, 17.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 MO000000212 e5

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1
stoichiometry:c239 : 1
stoichiometry:c236 : 1

m184*m183*m5*0.1

nodelay

--

true

0

false

PMID: 18775672,17997719,18347055,18180283 However, recent evidence suggests that IRAK1 is conjugated with K63-linked ubiquitin chains and provides a binding platform for IKK and possibly other signaling complexes

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1258.0, 426.0
19.0, 19.0

p84

p84

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c238 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 18775672,17997719,18347055,18180283 However, recent evidence suggests that IRAK1 is conjugated with K63-linked ubiquitin chains and provides a binding platform for IKK and possibly other signaling complexes

Go back
1230.0, 478.0
19.0, 19.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e92 MO000000210

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m94*m181*0.1

nodelay

--

true

0

false

--

Go back
1406.0, 614.0
19.0, 19.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e94 e95

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c244 : 1
stoichiometry:c245 : 1

m96*m97*0.1

nodelay

--

true

0

false

PMID: 18775672,18212736 The ABIN (A20-binding inhibitor of NF-KappaB) family proteins, ABIN-1, ABIN-2 and ABIN-3, also contain a UBD homologous to that of NEMO and can bind to K63 ubiquitinated proteins

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1310.0, 754.0
19.0, 19.0

p86

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e95 e97

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c247 : 1
stoichiometry:c248 : 1

m97*m99*0.1

nodelay

--

true

0

false

PMID: 18775672,18212736 The ABIN (A20-binding inhibitor of NF-KappaB) family proteins, ABIN-1, ABIN-2 and ABIN-3, also contain a UBD homologous to that of NEMO and can bind to K63 ubiquitinated proteins

Go back
1354.0, 886.0
19.0, 19.0

p86

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e95 e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c250 : 1
stoichiometry:c251 : 1

m97*m101*0.1

nodelay

--

true

0

false

PMID: 18775672,18212736 The ABIN (A20-binding inhibitor of NF-KappaB) family proteins, ABIN-1, ABIN-2 and ABIN-3, also contain a UBD homologous to that of NEMO and can bind to K63 ubiquitinated proteins

Go back
817.0, 853.0
21.0, 21.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e73 e49

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m75*m64*0.1

nodelay

--

true

0

false

PMID: 18775672,17703191,18239685 TAX1BP1 interacts with A20 and mediates the recruitment of A20 to K63-ubiquitinated RIP1 and TRAF6

Go back
750.0, 718.0
19.0, 19.0

p9

p9

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e16

MO000016632 e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 18775672 Activated IKK phosphorylates IKappaB-alpha, predominantly via the action of IKK2, triggering its lysine-48?linked polyubiquitination and proteasomal degradation, releasing associated NF-KappaB subunits to translocate into the nucleus

Go back
561.0, 613.0
21.0, 21.0

p89

p90

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e73 e48

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m75*m49*0.1

nodelay

--

true

0

false

PMID: 18775672,17703191,18239685 TAX1BP1 interacts with A20 and mediates the recruitment of A20 to K63-ubiquitinated RIP1 and TRAF6

Go back
1329.0, 1237.0
21.0, 21.0

p91

p91

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e79 e106

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c260 : 1
stoichiometry:c257 : 1

m81*m108*0.1

nodelay

--

true

0

false

PMID: 18775672,18022362,18022363 Synthetic c-IAP antagonists induce rapid degradation of c-IAP1 and c-IAP2 via the ubiquitin-proteasome pathway

Go back
1348.5, 1049.0
22.5, 22.5

p92

p92

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e107

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c259 : 1

m109*0.1

nodelay

--

true

0

false

PMID: 18775672,18022362,18022363 Synthetic c-IAP antagonists induce rapid degradation of c-IAP1 and c-IAP2 via the ubiquitin-proteasome pathway

Go back
1109.0, 1105.0
21.0, 21.0

p91

p93

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e106 e82

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c262 : 1
stoichiometry:c263 : 1

m108*m84*0.1

nodelay

--

true

0

false

PMID: 18775672,18022362,18022363 Synthetic c-IAP antagonists induce rapid degradation of c-IAP1 and c-IAP2 via the ubiquitin-proteasome pathway

Go back
1132.5, 977.0
22.5, 22.5

p92

p94

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e108

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c264 : 1
stoichiometry:c265 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 18775672,18022362,18022363 Synthetic c-IAP antagonists induce rapid degradation of c-IAP1 and c-IAP2 via the ubiquitin-proteasome pathway

Go back
669.0, 1393.0
21.0, 21.0

p95

p95

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e35 MO000023571

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1

m36*m7346*0.1

nodelay

--

true

0

false

PMID: 18775672 In unstimulated cells, homodimers of p50 and p52 actively repress transcription of NF-¦ÊB target genes to which they are bound by recruitment of histone deacetylases (HDAC).

Go back
573.0, 1493.0
21.0, 21.0

p95

p96

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e110 MO000023571

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c270 : 1
stoichiometry:c271 : 1

m112*m7346*0.1

nodelay

--

true

0

false

PMID: 18775672 In unstimulated cells, homodimers of p50 and p52 actively repress transcription of NF-¦ÊB target genes to which they are bound by recruitment of histone deacetylases (HDAC).

Go back
434.0, 1634.0
19.0, 19.0

p97

p97

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e69 e111 e109

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c274 : 1
stoichiometry:c275 : 1
stoichiometry:c273 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 18775672 Figure 1 PMID: 18775672 In unstimulated cells, homodimers of p50 and p52 actively repress transcription of NF-¦ÊB target genes to which they are bound by recruitment of histone deacetylases (HDAC).

Go back
681.0, 809.0
21.0, 21.0

p98

p98

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

e9 MO000016632

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c282 : 1
stoichiometry:c27 : 1

m9*m1617*0.1

nodelay

--

true

0

false

PMID: 18775672 S276 can be phosphorylated by protein kinase A (PKA) and mitogen- and stress-activated protein kinases (MSKs) 1 and 2, inducing binding to CREB-binding protein (CBP) and p300 co-activator complexes, which acetylate adjacent histones and RelA to stimulate target gene transcription. PMID: 18775672 Figure 3

Go back
541.0, 773.0
21.0, 21.0

p98

p99

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000019013 MO000016632

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c285 : 1
stoichiometry:c286 : 1

m3621*m1617*0.1

nodelay

--

true

0

false

PMID: 18775672 S276 can be phosphorylated by protein kinase A (PKA) and mitogen- and stress-activated protein kinases (MSKs) 1 and 2, inducing binding to CREB-binding protein (CBP) and p300 co-activator complexes, which acetylate adjacent histones and RelA to stimulate target gene transcription. PMID: 18775672 Figure 3

Go back
806.9155238698951, 117.38577546363581

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.3401177329985, 203.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
917.0, 361.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
857.9502305084579, 681.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.8420943484822, 333.47813477508436

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.0, 186.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
934.0, 296.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1013.0, 302.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.2150904250639, 195.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
445.0, 379.92144162202766

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.1274319850065, 385.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.0, 378.8207152494824

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.0, 308.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.3148177390107, 322.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.0, 365.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.9133753619602, 378.1740912999941

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 316.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.0, 378.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.3905904870531, 203.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
443.0, 327.4623275828737

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.0, 321.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1202.0, 438.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1185.0, 530.9692176736302

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.0, 318.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1183.8098895026626, 524.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1158.026732265546, 597.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.0, 519.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.0, 326.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1165.0, 736.3361829423374

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1253.488880506236, 745.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1117.9889426346601, 845.4204706649821

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.8576824797067, 326.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 461.87386041495085

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
582.0, 425.63351822399386

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.1941341382396, 199.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
860.4645320484739, 136.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 275.8255305823146

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.0, 279.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.6456206406082, 350.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.0, 461.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.44996637779775, 419.64814254032433

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.0, 330.02843222913117

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.3601918319166, 335.1348965210015

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.2790621242674, 308.95715430863214

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.15111740657096, 348.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.2145282297971, 280.4569614434444

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.37653242108996, 537.6388542106463

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
364.9893198795369, 521.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 353.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
920.7081452165539, 519.358989304142

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
914.0, 511.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.8702277421907, 353.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.0, 670.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 652.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 725.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
462.6715411810681, 1081.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
615.0, 282.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 1304.9806008066898

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
389.0, 1303.509867769654

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
414.0028719586806, 1297.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.0747764273433, 872.7346403445456

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 905.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1177.334453144719, 870.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.151117406571, 692.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.0, 864.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
902.2150203909493, 756.4559341368413

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1180.0, 951.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.7988760535901, 201.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
895.0, 749.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.4922747316119, 635.6744378067606

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.3902826712724, 698.8782684705435

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
792.6063496195658, 442.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
693.8386400886016, 333.7858463011151

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
825.0, 810.9935522735371

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1073.7777713001233, 597.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1074.0, 702.6568542494924

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1165.9922778767136, 697.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.913627698831, 775.1723892887157

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 273.7312732965925

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 913.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
958.8548123542763, 964.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 1018.1242162846543

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1087.1513543886333, 1028.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.2044960296896, 1059.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.3902826712724, 1108.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 435.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
825.0, 904.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1273.0, 887.8596008605664

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.8632840217354, 274.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1228.0, 1115.5952062052854

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1286.9083398852217, 967.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1168.8823322690735, 1106.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 438.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
453.0, 359.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1127.509867769654, 1183.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1115.0, 1213.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0, 759.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
654.8639539511775, 306.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0, 957.6909805511607

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1175.0, 1124.7984576762262

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1218.251710411625, 967.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1213.0, 1113.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0, 359.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 104.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 548.1049392463369

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1201.0, 1278.1530859662623

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1278.0, 1270.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1323.0, 1301.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1378.0, 1457.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
857.8704209107015, 790.3465738908959

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1389.6545148328548, 1241.9731806911404

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1212.0, 1493.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1201.7249260681654, 1577.079787787583

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1194.0, 1515.4757828400086

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
855.1230637558576, 790.8556797814026

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.0, 552.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1160.9795450530587, 1197.4244401322117

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1116.9818370427183, 1260.0

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1105.260551091179, 1304.6739760726869

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.5544770264883, 791.16698633096

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.4520240674143, 1123.8545224884986

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.66327154817003, 662.6504296625733

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.3019957125599, 326.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
480.0, 444.2774549373227

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1276.1554175279994, 1263.0

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1276.203320057911, 1395.4802557583166

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
659.7523067384537, 636.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0838022562883, 1121.1949350435189

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
244.0, 199.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
445.5711670617909, 1125.5840722363068

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 1008.7081432770395

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.89805476865973, 1086.0517700340185

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.0, 199.0

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
345.0, 904.3372546185766

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 185.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
438.0, 787.1367700943738

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.0, 783.134756321594

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0, 706.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.0471478201133, 802.2375569917375

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.163776591883, 794.0

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
626.0, 773.5424380787184

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.4108448750232, 699.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1258.0, 300.0

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 356.43670551028873

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1332.0, 364.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1284.8816940385575, 426.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1277.0, 440.0

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 184.0

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0, 734.8289791386326

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1256.9962157046132, 484.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.0, 314.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1249.0, 492.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1356.0, 621.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1409.0, 640.9874520661698

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1321.0289960765804, 629.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1336.9220526307042, 754.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1276.0, 773.9025708613195

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1328.0, 773.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1369.3614188106415, 763.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.9131792047609, 734.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1379.4452081011955, 906.7391236038202

c250

c250

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1364.0, 905.0

c251

c251

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 461.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
463.8587085313798, 603.49689686312

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
456.0, 573.8442390026428

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.6134655807892, 550.5357429061181

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1228.0, 1192.0

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1344.0, 1113.5116281122666

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1376.6568542494924, 1076.6568542494924

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.9805309734513, 781.9079646017699

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 733.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1352.8596008605664, 999.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1137.6428168329176, 993.0

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1126.9357777451098, 1133.441855214348

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1130.0, 1062.8776860867974

c263

c263

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1160.7964644935175, 1003.5137101279801

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.4860512140866, 784.6830694686546

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.4844874248342, 1300.0

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0, 1351.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 1414.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 1487.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.7089757929878, 830.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.1867236234419, 1353.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
591.0, 1514.0

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
383.0, 1412.0

c272

c272

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
446.0, 1387.7647231129047

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
456.9993449736922, 1644.0723863343655

c274

c274

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
456.76232225105247, 1528.0

c275

c275

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
732.1520335477054, 1377.8305115461203

c276

c276

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
687.0, 1377.9547237786924

c277

c277

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
521.6064954240192, 1276.663218864961

c278

c278

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
527.8284271247462, 1275.8284271247462

c279

c279

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
626.4692699053701, 1097.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
697.4613706778172, 1324.7234924119725

c280

c280

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
684.0, 1324.9986687190212

c281

c281

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
580.0, 823.2517177639627

c282

c282

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
639.0, 940.0

c283

c283

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
518.0, 719.0

c284

c284

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.2573305919324, 801.6749240125702

c285

c285

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 794.0

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 985.9921104517297

c287

c287

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 850.0

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.2250720367338, 937.4348703125456

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
250.0, 197.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
656.0, 438.0

c290

c290

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
798.4772614952592, 1115.6297910602875

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.0, 1109.0

c292

c292

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.4246907579123, 1389.0

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.0, 1272.0

c294

c294

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.9102341604552, 1435.1950713479823

c295

c295

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.66917493022476, 1435.0

c296

c296

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
370.99347803825145, 1476.0

c297

c297

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.0, 1498.0

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.8995700892396, 1573.4560373723305

c299

c299

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 113.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 314.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
362.0, 1556.0

c300

c300

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
363.0, 1492.0

c301

c301

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
516.9496456324975, 1387.7587938436127

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.0, 1412.0

c303

c303

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0, 1845.0

c304

c304

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.083765041378, 1492.0

c305

c305

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.4563983243081, 1893.0

c306

c306

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.0, 1221.0

c307

c307

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.4132406834243, 1913.0

c308

c308

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.0, 1272.0

c309

c309

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.56072828925915, 309.6144574458186

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.0, 1916.0

c310

c310

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.0, 1300.0

c311

c311

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.0, 1924.0

c312

c312

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.4118243819916, 852.0

c313

c313

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
571.776098595933, 1066.2525860153787

c314

c314

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.0537808947188, 925.731881015412

c315

c315

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
367.0, 1700.4596476396143

c316

c316

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
481.5806243441289, 1272.0

c317

c317

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
478.0, 1693.0

c318

c318

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 1764.9636518781476

c319

c319

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
351.0, 185.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
623.0, 1272.0

c320

c320

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.9846943615541, 1749.0

c321

c321

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 1625.6499256685026

c322

c322

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.0, 1597.5021524921863

c323

c323

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.4928463802848, 1530.8030792214015

c324

c324

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.5031589738537, 1385.806482696822

c325

c325

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.7822200796986, 201.0

c326

c326

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
831.0, 1591.0

c327

c327

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 1625.0

c328

c328

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.9850482685217, 1693.488880506236

c329

c329

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
383.65685424949237, 287.65685424949237

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.5895014325039, 1613.5693118796269

c330

c330

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
463.2812225055905, 201.0

c331

c331

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.3333067024648, 849.0

c332

c332

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.0, 927.0

c333

c333

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.3531602401445, 1265.0

c334

c334

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
472.0, 1248.0

c335

c335

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.18412975882075, 1293.0

c336

c336

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
455.5968358571538, 1455.0

c337

c337

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
439.8996247238159, 1530.0

c338

c338

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1410.0, 1636.0

c339

c339

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.29885918939317, 282.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1375.0, 1577.0

c340

c340

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1292.4647589618187, 1640.0

c341

c341

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1345.0097272694131, 1642.0

c342

c342

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1278.0, 1751.6568542494924

c343

c343

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1282.0, 1736.0

c344

c344

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1281.0, 1612.9525178510432

c345

c345

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
796.0, 868.0

c346

c346

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1158.4525138802312, 1604.0

c347

c347

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1213.9691115068547, 1648.9459451369958

c348

c348

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1156.2649649617454, 1642.0

c349

c349

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
444.0, 197.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
795.0, 869.0

c350

c350

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.0415014457498, 1364.2115427369135

c351

c351

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
854.0, 1348.0

c352

c352

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.0, 1358.0

c353

c353

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
864.0, 1328.9977061753586

c354

c354

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.0, 1262.0

c355

c355

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 1321.0

c356

c356

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.64228712553074, 1965.3654698245691

c357

c357

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
379.0, 1962.2063839173713

c358

c358

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
382.47440140654027, 1912.6991623111985

c359

c359

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
444.0, 290.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.2790762840248, 852.0

c360

c360

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
389.0, 1020.3591879744757

c361

c361

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
366.0, 1036.921434019705

c362

c362

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
360.2029023641114, 1029.0

c363

c363

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.0, 1237.6823294474204

c364

c364

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.9110539928504, 1215.189632179376

c365

c365

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0, 203.0

c366

c366

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.0, 1224.0

c367

c367

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.5852573154779, 1308.0

c368

c368

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.0, 665.0

c369

c369

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
332.9296349882005, 282.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1357.0, 324.0

c370

c370

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1397.0, 368.0

c371

c371

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.0, 183.0

c372

c372

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.0, 183.0

c373

c373

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1357.0, 306.19844303542396

c374

c374

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1407.7666052207824, 312.0

c375

c375

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.0, 1191.0574707553853

c376

c376

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 1201.0

c377

c377

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 1193.0

c378

c378

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.4862997330667, 438.0

c379

c379

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
327.0, 388.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.0, 1272.0

c380

c380

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 1634.0

c381

c381

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 1436.5293751748309

c382

c382

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.5923353935949, 1786.5322305830964

c383

c383

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.0, 1817.488880506236

c384

c384

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
753.2742248797756, 1634.0

c385

c385

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.44625251151, 1726.859891942764

c386

c386

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.5508668509282, 1821.6428033978248

c387

c387

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
964.0, 1260.0

c388

c388

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 1261.0

c389

c389

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
366.0, 408.0866716156727

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 1310.0

c390

c390

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1020.0, 1396.0

c391

c391

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.0, 1354.0

c392

c392

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1061.5441911050991, 1420.0

c393

c393

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.8844342046084, 1408.0

c394

c394

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.0, 1536.0

c395

c395

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 1527.7767997142835

c396

c396

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
926.0, 1573.0

c397

c397

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.2011942051716, 1408.0

c398

c398

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1012.0, 1584.0

c399

c399

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 67.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 402.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
991.1795472505926, 1481.0

c400

c400

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
985.0, 1657.0

c401

c401

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.2300312726662, 1533.0

c402

c402

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0, 1665.0

c403

c403

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.5681280646224, 1633.0

c404

c404

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
881.0, 1753.0

c405

c405

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
390.8372338729643, 516.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
351.0, 572.0592796928046

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
387.0, 566.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.6320038178839, 661.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 749.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.0, 781.1138811766288

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.5099858213954, 826.7568302382338

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
504.0, 785.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.0, 885.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.1972186206572, 116.08185157736477

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 1113.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.0, 438.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
698.0, 500.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.0075819419861, 557.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 609.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 609.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.36345376026, 424.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.0, 423.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
837.9764358840126, 445.6135719910779

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
827.0, 454.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.1599680095968, 110.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.017084139092, 532.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 581.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.0, 572.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.4008265501632, 588.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.9896781549733, 720.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.0, 733.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.0, 928.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.1828093948019, 1101.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.428457546758, 1217.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
513.2889679298512, 1273.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 100.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 1268.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
542.6349150843756, 1315.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.8999121222475, 1300.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
542.998068565882, 1364.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
939.0, 1092.2343829977174

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1045.0, 1077.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.0, 900.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
941.0, 137.4792800701431

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 140.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1008.0, 124.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.4615165988314, 115.64039679826074

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1070.186723623442, 207.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1020.0, 254.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.0, 276.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.0, 280.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1085.0, 344.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 310.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.631406251351, 353.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1223.0, 361.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1158.017510952682, 418.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1037.0, 442.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.0, 109.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1076.914322908596, 478.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1069.0, 491.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
967.0, 491.14472435875575

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1271.3104235544095, 583.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1269.0, 613.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1115.8899153183609, 626.3225869608813

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.0, 565.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 624.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.0, 345.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
927.8053782967668, 362.2055708575525

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back