1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18800159.csml convertedTime:2009.07.01.11:22

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title RAPping production of type I interferon in pDCs through mTOR.
Authors Costa-Mattioli M, Sonenberg N.
Affiliation Department of Biochemistry and the McGill Cancer Centre, McGill University,Montreal, Quebec, Canada.
Abstract The production of type I interferon -- the first line of defense against virusinfection and critical for innate immunity -- in plasmacytoid dendritic cellsrelies on the mammalian target of rapamycin.
PMID 18800159
Model Abstract

Entity

G010262:IL-6 G010329:TNF-alpha G010713:IRF-7 G011345:IL10 MO000000212:TRAF6 MO000000213:IRAK MO000000289:TNF-alpha MO000001935:Btk MO000007384:IL-6 MO000007702:IRF-7 MO000016573:MyD88 MO000017140:mTOR MO000017247:IL-10 MO000017390:FKBP12 MO000017518:4E-BP MO000017539:p70S6K2 MO000017540:p70S6K1 MO000020752:eIF-4E MO000032376:raptor MO000038220:mLST8 MO000039077:IRAK-4 MO000041457:IRF-7{p} MO000042012:TLR9 MO000064071:EIF4B e1: e10: e11:p70S6K2{p} e12:4E-BP{p} e13:4E-BP:eIF-4E e14:EIF4B{p} e15:CpGA e16:mTOR{p} e17:rapamycin e18:rapamycin:FKBP12 e19:mTORC1:rapamycin:FKBP12 e2: e20: e21: e22: e23:CpG-A:TLR9 e24:TLR7 ligand:TLR7 e25:type I interferon e26:type I interferon e27:CpG-A:TLR9:MYD88 e28:CpG-A:TLR9:MYD88:TRAF6:IRAK1:IRAk4:IRF-7:Btk e29:CpG-A:TLR9:MYD88:TRAF6:IRAK1:IRAk4:Btk e3: e30:IRF-7{p} e31:type I interferon e32:IFN-alpha4 e33:IFN-beta1 e34:IFI44 e35:IFI202B e36:CCL7 e37:CCL8 e38:CCL12 e4: e5:raptor:mTOR:mLST8 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:p70S6K1{p} e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p4 p5 p6 p7 p8 p9
Model Detail
824.0, 1312.0
24.0, 24.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p18 p19

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
1006.0, 1326.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p16 p17

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
1063.0, 1391.0
26.0, 26.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p35

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
1067.0, 1451.0
34.0, 34.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
805.0, 469.0
30.0, 30.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1154.0, 872.0
22.0, 22.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
1345.0, 1297.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p17

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1302.0, 638.0
24.0, 24.0

Btk

--

MO000001935

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m367

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000001935

--

Go back
450.0, 1274.0
28.0, 28.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18 p19

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
1157.0, 733.0
30.0, 30.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p24

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
882.0, 442.0
28.0, 28.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
864.0, 740.0
24.0, 24.0

mTOR

--

MO000017140

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p9

true true true true

csml-variable:Double

m2018

10

false

infinite

0

unit false false false
InterProIPR003151
TRANSPATHMO000017140

--

Go back
1374.0, 1422.0
28.0, 28.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
474.0, 802.0
28.0, 28.0

FKBP12

--

MO000017390

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m2224

10

false

infinite

0

unit false false false
InterProIPR001179
TRANSPATHMO000017390

--

Go back
961.0, 957.0
30.0, 30.0

4E-BP

--

MO000017518

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m2314

10

false

infinite

0

unit false false false
TRANSPATHMO000017518

--

Go back
832.0, 972.0
24.0, 24.0

p70S6K2

--

MO000017539

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p11

true true true true

csml-variable:Double

m2332

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017539

--

Go back
629.0, 961.0
22.0, 22.0

p70S6K1

--

MO000017540

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p12

true true true true

csml-variable:Double

m2333

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017540

--

Go back
1031.0, 943.0
26.0, 26.0

eIF-4E

--

MO000020752

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4 p10

p5 p35

true true true true

csml-variable:Double

m5183

10

false

infinite

0

unit false false false
TRANSPATHMO000020752

--

Go back
794.0, 782.0
28.0, 28.0

raptor

--

MO000032376

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m11333

10

false

infinite

0

unit false false false
TRANSPATHMO000032376

--

Go back
942.0, 798.0
28.0, 28.0

mLST8

--

MO000038220

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m16445

10

false

infinite

0

unit false false false
TRANSPATHMO000038220

--

Go back
1254.0, 712.0
26.0, 26.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
543.0, 611.0
26.0, 26.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p26

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
1001.0, 417.0
29.0, 29.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
722.0, 1042.0
28.0, 28.0

EIF4B

--

MO000064071

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m38945

10

false

infinite

0

unit false false false
TRANSPATHMO000064071

--

Go back
343.4006080107115, 221.06629213820491
1154.2296733303224, 1675.9414856756273

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
336.5215305468778, 260.68228171132546
1118.802009148072, 1573.839837009545

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
855.0, 1098.3902439024391
34.51219512195122, 27.609756097560968

p70S6K2{p}

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

p3 p11

p7

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
944.0, 1102.7560975609756
32.80487804878049, 26.24390243902439

4E-BP{p}

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

p4 p10

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1143.0, 1102.209944751381
25.01104972375691, 27.79005524861879

4E-BP:eIF-4E

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p4 p6 p10 p35

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
727.0, 1185.9024390243906
25.121951219512194, 20.097560975609753

EIF4B{p}

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7 p8

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1079.0, 451.054565701559
49.84409799554565, 17.44543429844098

CpGA

--

e15

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
636.0, 738.7560975609758
32.80487804878048, 26.243902439024385

mTOR{p}

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
468.0, 878.1059714045416
47.46005046257359, 26.894028595458366

rapamycin

--

e17

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1 p13 p16 p17 p18 p19 p20 p21 p22 p28 p29 p30 p31 p32 p33 p34

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
499.0, 721.1657458563535
26.85082872928177, 29.834254143646408

rapamycin:FKBP12

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
661.0, 877.3823529411765
21.970588235294116, 36.617647058823536

mTORC1:rapamycin:FKBP12

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p2 p3 p4

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
343.4006080107115, 221.06629213820491
1154.2296733303224, 1675.9414856756273

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1008.0, 391.96125765649595
191.86160468776652, 320.31132308042373

--

e20

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false true false

--

Go back
1008.0, 391.96125765649595
191.86160468776652, 320.31132308042373

--

e21

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false true false

--

Go back
1008.0, 391.96125765649595
191.86160468776652, 320.31132308042373

--

e22

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false true false

--

Go back
1007.5, 472.4411313308485
16.305415479061608, 31.5588686691515

CpG-A:TLR9

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p9 p10 p11 p12 p16 p18 p20 p23 p28 p29 p30 p31 p32 p33 p34

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1189.5, 511.7195790396843
21.32821749616312, 41.280420960315716

TLR7 ligand:TLR7

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p17 p19 p21

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
774.0, 1426.0484429065743
41.15916955017301, 21.95155709342561

type I interferon

--

e25

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27

p20 p21

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
451.0, 1422.44527595884
18.873713751169316, 43.554724041159965

type I interferon

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20 p21

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1009.5, 532.3228115250505
21.985318407047167, 30.677188474949524

CpG-A:TLR9:MYD88

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1001.0, 593.2058823529412
22.676470588235293, 37.794117647058826

CpG-A:TLR9:MYD88:TRAF6:IRAK1:IRAk4:IRF-7:Btk

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1020.0, 672.4411764705882
23.735294117647058, 39.55882352941177

CpG-A:TLR9:MYD88:TRAF6:IRAK1:IRAk4:Btk

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
366.48520147731807, 244.15088560481138
1108.0604863971098, 1629.772298742416

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
891.0, 1291.0
26.0, 26.0

IRF-7{p}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p27

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
794.0, 1366.9210665959142
53.441231095781376, 11.578933404085964

type I interferon

--

e31

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p27

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
990.0, 1569.61937716263
34.463667820069205, 18.380622837370247

IFN-alpha4

--

e32

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p31

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
874.0, 1626.7612456747406
36.07266435986159, 19.238754325259517

IFN-beta1

--

e33

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
944.0, 1621.8235294117649
39.70588235294118, 21.176470588235297

IFI44

--

e34

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p28

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
934.0, 1364.3321799307962
44.37716262975779, 23.66782006920415

IFI202B

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p33

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
676.0, 1605.3252595155711
40.640138408304495, 21.674740484429066

CCL7

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p34

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
751.0, 1685.1314878892736
41.003460207612456, 21.868512110726645

CCL8

--

e37

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
803.0, 1552.4117647058824
42.35294117647059, 22.58823529411765

CCL12

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p29

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
409.19169939054, 284.54892417137256
1022.6474905706663, 1548.9762216092927

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
865.5, 905.1596623233621
21.385575334923843, 29.84033767663792

raptor:mTOR:mLST8

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2 p3 p4 p14

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
589.7239061537588, 1239.5797278015184
627.6919234269158, 569.2476102586751

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
657.5193094289184, 1253.0700686087916
367.030286696558, 551.7143163082022

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
597.9061099973126, 1247.1774885133898
611.3275157398086, 554.0520888349317

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
599.0749962606776, 1248.3463747767555
608.9897432130784, 551.7143163082022

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
589.7239061537588, 1239.5797278015184
627.6919234269158, 569.2476102586751

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
589.7239061537588, 1239.5797278015184
627.6919234269158, 569.2476102586751

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
599.0749962606776, 1248.3463747767555
608.9897432130784, 551.7143163082022

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1047.9273213927734, 1473.3569804744857
39.214742519883316, 35.49966164957864

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
945.0653302166685, 1637.001057345563
111.04419501965921, 100.5242186493759

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
589.7239061537588, 1239.5797278015184
627.6919234269158, 569.2476102586751

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
640.0, 1110.9512195121952
32.560975609756106, 26.048780487804827

p70S6K1{p}

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

p2 p12

p8 p23

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
737.6673607261271, 1492.5486620687464
19.878080918530536, 9.570927849662864

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
737.0035753377274, 1464.0058903675663
68.03800231095305, 122.46840415971559

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
765.5463470389084, 1543.6601369755124
10.620566214392658, 10.620566214392676

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
358.5655023782109, 227.81041316510394
1131.9397108167605, 1603.9293319322371

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
362.6094742095442, 256.11821598443646
1085.883252520186, 1576.7024826593101

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
373.3933990930992, 284.42601880376895
1080.92559982812, 1556.024424685128

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
867.0, 839.0
17.0, 17.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017140 MO000038220 MO000032376 e17

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c117 : 1
stoichiometry:c4 : 1

m2018*m16445*m11333*0.1

nodelay

--

true

0

false

PMID: 18800159 mTOR associates with the adaptor proteins raptor and LST8 (G¦ÂL) to form a complex called ¡ÆmTORC1¡Ç that initiates translation by phosphorylating members of at least two families of translational modulators, the p70 ribosomal S6 kinases (S6Ks)1 and 2 (S6K1,2) and the eIF4E-binding proteins (4E-BPs). PMID: 18800159 In the second mechanism, rapamycin treatment disrupts mTOR-raptor interaction, which prevents mTOR from phosphorylating 4E-BPs.

Go back
989.0, 1029.0
21.0, 21.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e23 e13

e12 MO000020752

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c28 : 1
stoichiometry:c27 : 1
stoichiometry:c115 : 1

m23*m13*0.1

nodelay

--

true

0

false

PMID: 18800159 the TLR9 ligand CpG-A triggers rapid phosphorylation of mTOR and its ¡Ædownstream¡Ç targets 4E-BPs and S6Ks.

Go back
826.0, 1042.0
20.0, 20.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017539 e23

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c32 : 1
stoichiometry:c31 : 1

m2332*m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the TLR9 ligand CpG-A triggers rapid phosphorylation of mTOR and its ¡Ædownstream¡Ç targets 4E-BPs and S6Ks.

Go back
585.0, 1041.0
21.0, 21.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017540 e23

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c35 : 1
stoichiometry:c34 : 1

m2333*m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the TLR9 ligand CpG-A triggers rapid phosphorylation of mTOR and its ¡Ædownstream¡Ç targets 4E-BPs and S6Ks.

Go back
573.0, 807.5
18.5, 18.5

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000017390

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c44 : 1
stoichiometry:c37 : 1

m17*m2224*0.1

nodelay

--

true

0

false

PMID: 18800159 Pulendran and colleagues now show that phosphorylation of mTOR, 4E-BPs and S6Ks in response to TLR9 activation is blocked by the highly specific drug rapamycin, a macrolide that, in a complex with the immunophilin FKBP12, binds to mTORC1 and inhibits mTORC1 activity

Go back
663.0, 807.0
17.0, 17.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 e5

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m18*m5*0.1

nodelay

--

true

0

false

PMID: 18800159 Pulendran and colleagues now show that phosphorylation of mTOR, 4E-BPs and S6Ks in response to TLR9 activation is blocked by the highly specific drug rapamycin, a macrolide that, in a complex with the immunophilin FKBP12, binds to mTORC1 and inhibits mTORC1 activity

Go back
1053.0, 477.0
21.0, 21.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e15

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m19828*m15*0.1

nodelay

--

true

0

false

PMID: 18800159 both TLR7- and TLR9-mediated production of type I interferon, tumor necrosis factor and interleukin 6 (IL-6) is suppressed in human and mouse pDCs treated with rapamycin.

Go back
1217.0, 1301.0
21.0, 21.0

p16

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e23 e17 G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m23*m93309*0.1

nodelay

--

true

0

false

PMID: 18800159 both TLR7- and TLR9-mediated production of type I interferon, tumor necrosis factor and interleukin 6 (IL-6) is suppressed in human and mouse pDCs treated with rapamycin.

Go back
1270.0, 1226.5
19.5, 19.5

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e24 e17

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c52 : 1

m93309*m24*0.1

nodelay

--

true

0

false

PMID: 18800159 both TLR7- and TLR9-mediated production of type I interferon, tumor necrosis factor and interleukin 6 (IL-6) is suppressed in human and mouse pDCs treated with rapamycin.

Go back
589.0, 1245.0
21.0, 21.0

p18

p18

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e17 e23

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c57 : 1

m93248*m23*0.1

nodelay

--

true

0

false

PMID: 18800159 both TLR7- and TLR9-mediated production of type I interferon, tumor necrosis factor and interleukin 6 (IL-6) is suppressed in human and mouse pDCs treated with rapamycin.

Go back
475.0, 1351.0
17.0, 17.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e17 e24

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c59 : 1

m93248*m24*0.1

nodelay

--

true

0

false

PMID: 18800159 both TLR7- and TLR9-mediated production of type I interferon, tumor necrosis factor and interleukin 6 (IL-6) is suppressed in human and mouse pDCs treated with rapamycin.

Go back
647.0, 1039.0
17.0, 17.0

p2

p2

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 MO000017540 e19

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c41 : 1
stoichiometry:c7 : 1

m5*m2333*0.1

nodelay

--

true

0

false

PMID: 18800159 mTOR associates with the adaptor proteins raptor and LST8 (G¦ÂL) to form a complex called ¡ÆmTORC1¡Ç that initiates translation by phosphorylating members of at least two families of translational modulators, the p70 ribosomal S6 kinases (S6Ks)1 and 2 (S6K1,2) and the eIF4E-binding proteins (4E-BPs). PMID: 18800159 Pulendran and colleagues now show that phosphorylation of mTOR, 4E-BPs and S6Ks in response to TLR9 activation is blocked by the highly specific drug rapamycin, a macrolide that, in a complex with the immunophilin FKBP12, binds to mTORC1 and inhibits mTORC1 activity

Go back
565.0, 1401.0
21.0, 21.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e25 e23 e17

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c64 : 1

m25*m23*0.1

nodelay

--

true

0

false

PMID: 18800159 both TLR7- and TLR9-mediated production of type I interferon, tumor necrosis factor and interleukin 6 (IL-6) is suppressed in human and mouse pDCs treated with rapamycin.

Go back
550.0, 1490.0
19.0, 19.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e25 e24 e17

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c71 : 1
stoichiometry:c65 : 1

m25*m24*0.1

nodelay

--

true

0

false

PMID: 18800159 both TLR7- and TLR9-mediated production of type I interferon, tumor necrosis factor and interleukin 6 (IL-6) is suppressed in human and mouse pDCs treated with rapamycin.

Go back
1274.0, 1458.0
19.0, 19.0

p22

p22

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345 e17

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c72 : 1

m94230*0.1

nodelay

--

true

0

false

PMID: 18800159 The effect of rapamycin is not limited to pDCs, as the production of IL-10, IL-6 and tumor necrosis factor is also impaired in bone marrow? derived DCs treated with rapamycin

Go back
1073.0, 537.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000016573 e6

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c76 : 1

m23*m1572*m6*0.1

nodelay

--

true

0

false

PMID: 18800159 they find that a decrease in S6K activity resulting from the use of rapamycin or siRNA specific for S6K1,2 impedes the production of type I interferon and formation of the TLR9-MyD88 complex. PMID: 18800159 S6K phosphorylation mediated by mTOR promotes formation of the TLR9-MyD88 complex

Go back
1075.0, 603.0
17.0, 17.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000000212 MO000039077 MO000000213 MO000001935 MO000007702

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m27*m183*m17258*m184*m367*m980*0.1

nodelay

--

true

0

false

PMID: 18800159 The interaction of TLR with MyD88 in pDCs elicits the formation of multifactor signaling transduction complex that contains the kinases IRAK1 and IRAK4, the ubiquitin ligase TRAF6, the tyrosine kinase BTK and IRF7

Go back
682.0, 614.0
19.0, 19.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e28

MO000041457 e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 18800159, 18641647 IRF7 is phosphorylated by IRAK1- IRAK4 and then translocates to the nucleus, where it initiates the transcription of genes encoding type I interferons

Go back
586.0, 702.0
19.0, 19.0

p26

p26

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041457

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 18800159, 18641647 IRF7 is phosphorylated by IRAK1- IRAK4 and then translocates to the nucleus, where it initiates the transcription of genes encoding type I interferons

Go back
879.0, 1395.0
17.0, 17.0

p27

p27

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e30 e31

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c91 : 1

m30*m31*0.1

nodelay

--

true

0

false

PMID: 18800159, 18641647 IRF7 is phosphorylated by IRAK1- IRAK4 and then translocates to the nucleus, where it initiates the transcription of genes encoding type I interferons

Go back
954.0, 1462.0
19.0, 19.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 e17

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c110 : 1
stoichiometry:c96 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the expression of a subset of genes encoding interferons and cytokines such as interferon-¦Á4, interferon-¦Â1, IFI44, IFI202B, CCL7, CCL8 and CCL12 is induced by CpG-A but is repressed by rapamycin.

Go back
813.0, 1481.0
21.0, 21.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 e17

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c112 : 1
stoichiometry:c100 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the expression of a subset of genes encoding interferons and cytokines such as interferon-¦Á4, interferon-¦Â1, IFI44, IFI202B, CCL7, CCL8 and CCL12 is induced by CpG-A but is repressed by rapamycin.

Go back
862.0, 1038.0
19.0, 19.0

p3

p3

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017539 e5 e19

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c42 : 1
stoichiometry:c9 : 1

m2332*m5*0.1

nodelay

--

true

0

false

PMID: 18800159 mTOR associates with the adaptor proteins raptor and LST8 (G¦ÂL) to form a complex called ¡ÆmTORC1¡Ç that initiates translation by phosphorylating members of at least two families of translational modulators, the p70 ribosomal S6 kinases (S6Ks)1 and 2 (S6K1,2) and the eIF4E-binding proteins (4E-BPs). PMID: 18800159 Pulendran and colleagues now show that phosphorylation of mTOR, 4E-BPs and S6Ks in response to TLR9 activation is blocked by the highly specific drug rapamycin, a macrolide that, in a complex with the immunophilin FKBP12, binds to mTORC1 and inhibits mTORC1 activity

Go back
761.0, 1617.0
21.0, 21.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 e17

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c113 : 1
stoichiometry:c99 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the expression of a subset of genes encoding interferons and cytokines such as interferon-¦Á4, interferon-¦Â1, IFI44, IFI202B, CCL7, CCL8 and CCL12 is induced by CpG-A but is repressed by rapamycin.

Go back
997.0, 1416.0
19.0, 19.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 e17

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c109 : 1
stoichiometry:c94 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the expression of a subset of genes encoding interferons and cytokines such as interferon-¦Á4, interferon-¦Â1, IFI44, IFI202B, CCL7, CCL8 and CCL12 is induced by CpG-A but is repressed by rapamycin.

Go back
882.0, 1550.0
19.0, 19.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 e17

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c111 : 1
stoichiometry:c95 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the expression of a subset of genes encoding interferons and cytokines such as interferon-¦Á4, interferon-¦Â1, IFI44, IFI202B, CCL7, CCL8 and CCL12 is induced by CpG-A but is repressed by rapamycin.

Go back
946.0, 1274.0
19.0, 19.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 e17

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c108 : 1
stoichiometry:c97 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the expression of a subset of genes encoding interferons and cytokines such as interferon-¦Á4, interferon-¦Â1, IFI44, IFI202B, CCL7, CCL8 and CCL12 is induced by CpG-A but is repressed by rapamycin.

Go back
687.0, 1515.0
17.0, 17.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 e17

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c114 : 1
stoichiometry:c98 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the expression of a subset of genes encoding interferons and cytokines such as interferon-¦Á4, interferon-¦Â1, IFI44, IFI202B, CCL7, CCL8 and CCL12 is induced by CpG-A but is repressed by rapamycin.

Go back
1070.0, 1174.0
19.0, 19.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010713 MO000020752 e13

MO000007702

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c119 : 1

m93631*m5183*0.1

nodelay

--

true

0

false

PMID: 18800159 The mTOR-dependent phophorylation of 4 E-BPs results in low-affinity binding to eIF4E and thus elicit more translation of IRF7 mRNA. PMID: 18800159, 18272964 One of these mRNAs, IRF7, has been shown to be translationally controlled by 4E-BPs and is responsible for the enhanced production of type I interferon and virus-resistant phenotype of MEFs doubly deficient in 4E-BP1 and 4E-BP2. PMID: 18800159 hypophosphorylated 4E-BPs then bind to the cap-binding protein eIF4E with high affinity, thus decreasing the translation of a subset of mRNAs.

Go back
949.0, 1045.0
21.0, 21.0

p4

p4

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 e19 e13

e12 MO000020752

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c43 : 1
stoichiometry:c13 : 1
stoichiometry:c12 : 1
stoichiometry:c116 : 1

m5*m13*0.1

nodelay

--

true

0

false

PMID: 18800159 mTOR associates with the adaptor proteins raptor and LST8 (G¦ÂL) to form a complex called ¡ÆmTORC1¡Ç that initiates translation by phosphorylating members of at least two families of translational modulators, the p70 ribosomal S6 kinases (S6Ks)1 and 2 (S6K1,2) and the eIF4E-binding proteins (4E-BPs). PMID: 18800159 Pulendran and colleagues now show that phosphorylation of mTOR, 4E-BPs and S6Ks in response to TLR9 activation is blocked by the highly specific drug rapamycin, a macrolide that, in a complex with the immunophilin FKBP12, binds to mTORC1 and inhibits mTORC1 activity

Go back
1034.0, 1018.5
19.5, 19.5

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000020752 MO000017518

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m5183*m2314*0.1

nodelay

--

true

0

false

PMID: 18800159 4E-BPs (of which three forms exist in mammals) inhibit translation by binding the cap-binding protein eIF4E

Go back
1145.0, 1205.0
21.0, 21.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e13

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18800159 4E-BPs (of which three forms exist in mammals) inhibit translation by binding the cap-binding protein eIF4E

Go back
757.0, 1113.0
21.0, 21.0

p7

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000064071 e11

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c19 : 1

m38945*m11*0.1

nodelay

--

true

0

false

PMID: 18800159 the S6Ks phosphorylate and activate (among other substrates) eIF4B, a translation-initiation factor.

Go back
710.0, 1118.0
19.0, 19.0

p8

p8

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000064071 e6

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c23 : 1
stoichiometry:c22 : 1

m38945*m6*0.1

nodelay

--

true

0

false

PMID: 18800159 the S6Ks phosphorylate and activate (among other substrates) eIF4B, a translation-initiation factor.

Go back
742.0, 742.0
19.0, 19.0

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017140 e23

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1

m2018*m23*0.1

nodelay

--

true

0

false

PMID: 18800159 the TLR9 ligand CpG-A triggers rapid phosphorylation of mTOR and its ¡Ædownstream¡Ç targets 4E-BPs and S6Ks.

Go back
876.0, 764.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.2329109362784, 935.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
824.0, 1502.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1007.0789435245281, 504.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
957.6008951323524, 504.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
965.4169690064175, 504.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
827.5039179163367, 504.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
893.9192998091423, 504.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
701.359061815518, 504.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
775.6795920822314, 504.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
507.0, 905.0

c108

c108

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
505.0, 905.0

c109

c109

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
885.0, 935.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
503.0, 905.0

c110

c110

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
500.0, 905.0

c111

c111

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
499.0, 905.0

c112

c112

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
497.0, 905.0

c113

c113

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
496.0, 905.0

c114

c114

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1006.0, 976.1074072548595

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
969.0, 975.1192895849364

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.0, 849.4516387521771

c117

c117

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1076.0, 1200.998368013039

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1082.0, 770.8265751078891

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.0, 1066.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1046.0, 969.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1091.9896372747346, 1128.0

c121

c121

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
977.6490943508878, 1061.343364165301

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
991.0, 984.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.0, 1035.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1044.0, 969.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1156.0, 1130.0

c17

c17

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
743.0, 1070.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.8718326344709, 1134.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.3000745961197, 818.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.9459069717682, 1114.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
723.7870092506352, 1070.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.0, 1137.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.0, 1125.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
769.0, 752.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.0, 752.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.6683169380426, 497.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
970.7369682647644, 1050.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1017.1875486832259, 1048.5127117624788

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.2436963776992, 504.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
822.0, 807.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.0347134725422, 996.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.0, 1062.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.4361500440501, 504.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.8646187432906, 983.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 1062.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.7810441640975, 499.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.0, 830.1025117694829

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
530.2150904250639, 757.0665337597682

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 743.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.1245120030904, 823.6388636574925

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.0, 856.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.0, 824.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
657.4137683588438, 914.0

c41

c41

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
683.0, 904.0

c42

c42

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
683.0, 902.0

c43

c43

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
502.0, 816.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.0, 446.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 488.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1080.6564023547028, 469.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 504.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
515.0, 905.0

c49

c49

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
670.92262804667, 926.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1238.0, 1312.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1034.0, 1314.082838461403

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1290.0, 1245.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1034.0, 1242.9602628706855

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1202.0, 553.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
515.0, 902.0

c55

c55

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
617.6840091603793, 1261.2262082614184

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
485.7891740141512, 1259.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.95837618370825, 1325.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.19776902317903, 1309.6921915811265

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.0, 983.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 905.0

c60

c60

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
484.07173733932797, 905.0

c61

c61

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
609.8148499942583, 504.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
497.2334473172744, 544.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
477.71623312129077, 1415.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.9726042969964, 1452.9220899170605

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.9457803145704, 1413.9298253559602

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.7267426978774, 1443.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
571.4130514820378, 548.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
584.4385308614236, 504.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
656.0, 1056.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 905.0

c70

c70

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
493.0, 905.0

c71

c71

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1293.0, 1442.3593175009767

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1101.0, 1468.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
510.0, 905.0

c74

c74

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1024.0, 495.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.0, 548.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1031.0, 560.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.0, 463.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0, 564.4208389903996

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
849.0, 996.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 491.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.8074888811523, 621.202153630341

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1088.3099343641636, 627.6592560495949

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1099.8911513906571, 614.3151918984429

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.3410776592539, 626.7197503492561

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 612.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.9936076697743, 612.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.0, 624.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.0, 626.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.0, 637.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 1057.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 721.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.5285977302406, 1407.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.3151918984429, 1317.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
833.0, 1379.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1007.0, 1435.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.0, 1569.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.0, 1481.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
956.0, 1293.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 1532.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
772.0, 1638.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back