PMID: 7542643, 1698311 CD14 has been assigned a functional role, serving as a receptor for LPS in association with LBP in which heparinized human blood cultured for 16 h with LPS resulted in TNF-alpha production, whose synthesis and release could be nearly eliminated by pre-treatment with a CD14 blocking mAb

PMID: 7542643, 7681082 A recent report described the importance of CD14 in LPS recognition by human monocytes and alveolar macrophages, leading to the synthesis and release of TNF-alpha, IL-6, and IL-8. The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.

PMID: 7542643, 1708813 TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.

PMID: 7542643, 1708813 TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.

PMID: 7542643, 1708813 TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.

PMID: 7542643, 1708813 TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.

PMID: 7542643, 1708813 TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.

PMID: 7542643, 1708813 TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.

PMID: 7542643 LPS appears to upregulate CD 14 transcripts, followed by increased expression of CDI4 protein on the cell surface.

PMID: 7542643 LPS appears to upregulate CD 14 transcripts, followed by increased expression of CDI4 protein on the cell surface.

PMID: 7542643 recombinant sCD14 produced using a baculovirus expression system was shown to specifically bind LPS

PMID: 7542643, 1698311 CD14 has been assigned a functional role, serving as a receptor for LPS in association with LBP in which heparinized human blood cultured for 16 h with LPS resulted in TNF-alpha production, whose synthesis and release could be nearly eliminated by pre-treatment with a CD14 blocking mAb. Binding of erythrocyte- LPS complexes to macrophages could be inhibited by preincubation of macrophages with anti-CD14 blocking mAb.

PMID: 7542643 Inhibition of LPS induced IL-6 and E-selectin expression by anti-CD14 mAb was maximal at low concentrations of LPS.

PMID: 7542643 Inhibition of LPSinduced IL-6 and E-selectin expression by anti-CD14 mAb was maximal at low concentrations of LPS.

PMID: 7542643, 2402637 In rabbit peritoneal macrophages, addition of LBP enhanced TNF-alpha production when cells were stimulated with LPS. This increase in TNF-alpha protein was accompanied by a concomitant increase in the rate and synthesis of TNF-alpha mRNA as visualized on Northern blots.

PMID: 7542643, 2402637 In rabbit peritoneal macrophages, addition of LBP enhanced TNF-alpha production when cells were stimulated with LPS. This increase in TNF-alpha protein was accompanied by a concomitant increase in the rate and synthesis of TNF-alpha mRNA as visualized on Northern blots. PMID: 7542643, 1698311 CD14 has been assigned a functional role, serving as a receptor for LPS in association with LBP in which heparinized human blood cultured for 16 h with LPS resulted in TNF-alpha production, whose synthesis and release could be nearly eliminated by pre-treatment with a CD14 blocking mAb

PMID: 7542643, 1607653 when LBP was added during LPS stimulation, macrophages responded with a more rapid induction of TNF-alpha and IL-lbeta mRNA, higher steady state mRNA levels, and increased mRNA stability which was shown to correlate with increased TNF-alpha and IL-lbeta protein.

PMID: 7542643, 1607653 when LBP was added during LPS stimulation, macrophages responded with a more rapid induction of TNF-alpha and IL-lbeta mRNA, higher steady state mRNA levels, and increased mRNA stability which was shown to correlate with increased TNF-alpha and IL-lbeta protein.

PMID: 7542643 All three members of the CD18 family (CDlla/CD18, CDllb/CD18, and CD 1Ic/CD 18) are capable of binding LPS.

PMID: 7542643 All three members of the CD18 family (CDlla/CD18, CDllb/CD18, and CD 1Ic/CD 18) are capable of binding LPS.

PMID: 7542643 All three members of the CD18 family (CDlla/CD18, CDllb/CD18, and CD 1Ic/CD 18) are capable of binding LPS.

PMID: 7542643, 1717586 LPS treatment has been shown to induce a rapid upregulation of CDllb/ CD 18 expression on human neutrophils, believed to be mediated by CD14, since anti-CD14 mAb specifically inhibited LPS-induced CDllb/CD18 expression (Lynn et al., 1991).

PMID: 7542643, 1698311 CD14 has been assigned a functional role, serving as a receptor for LPS in association with LBP in which heparinized human blood cultured for 16 h with LPS resulted in TNF-alpha production, whose synthesis and release could be nearly eliminated by pre-treatment with a CD14 blocking mAb

PMID: 7542643, 1717586 LPS treatment has been shown to induce a rapid upregulation of CDllb/ CD 18 expression on human neutrophils, believed to be mediated by CD14, since anti-CD14 mAb specifically inhibited LPS-induced CDllb/CD18 expression (Lynn et al., 1991).

PMID: 7542643, 2456339 one of the most well-characterized LPS receptors in addition to CD18 and CD14, is the 73 kDa (80 kDa) receptor. PMID: 7542643 Two mAb were obtained from a series of clones, designated mAb 3D7 and mAb 5D3 were able to inhibit the interaction of LPS with the 73 kDa LPS receptor in a dose-dependent manner, reflecting specificity.

PMID: 7542643, 2002021 The p73 receptor has been demonstrated to bind soluble peptidoglycan on mouse B lymphocytes.

PMID: 7542643, 7690343 A 38 kDa cell surface protein displaying affinity for LPS was identified on mouse lymphocytes, macrophages, splenocytes, J774.1 cells and 70Z/3 cells using 125I-ASD-LPS.

PMID: 7542643, 1708813 TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.

PMID: 7542643, 1376258 CD14 plays an important role in macrophage production of IL-1 in response to LPS. The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.

PMID: 7542643, 1376258 CD14 plays an important role in macrophage production of IL-1 in response to LPS. The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.

PMID: 7542643, 7681082 A recent report described the importance of CD14 in LPS recognition by human monocytes and alveolar macrophages, leading to the synthesis and release of TNF-alpha, IL-6, and IL-8. The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18. PMID: 7542643 Inhibition of LPS induced IL-6 and E-selectin expression by anti-CD14 mAb was maximal at low concentrations of LPS.

PMID: 7542643, 7681082 A recent report described the importance of CD14 in LPS recognition by human monocytes and alveolar macrophages, leading to the synthesis and release of TNF-alpha, IL-6, and IL-8. The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.

PMID: 7542643, 7681082 A recent report described the importance of CD14 in LPS recognition by human monocytes and alveolar macrophages, leading to the synthesis and release of TNF-alpha, IL-6, and IL-8. The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.