1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/8485905.csml convertedTime:2009.07.01.11:23

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multipleligand specificities and functions.
Authors Ross GD, Vetvicka V.
Affiliation Department of Microbiology and Immunology, University of Louisville, KY 40292.
Abstract The C3 receptor CR3 is expressed on phagocytic cells, minor subsets of B and Tcells, and natural killer (NK) cells. It has important functions both as anadhesion molecule and a membrane receptor mediating recognition of diverseligands such as intercellular adhesion molecule-1 (ICAM-1) and fixed iC3b. Thereceptor is capable of undergoing an activation event that regulates both itsspecificity for various ligands and its ability to mediate phagocytosis orextracellular cytotoxicity. Certain bacteria express carbohydrates orlipopolysaccharides (LPS) that can bind to and activate CR3, allowing thereceptor to assume its activated state. Soluble beta-glucan derived from theyeast Saccharomyces cerevisiae is a particularly potent stimulator of CR3, andproduces an activated state of the receptor that permits neutrophil phagocytosisof iC3b-coated erythrocytes or NK, cell cytotoxicity of iC3b-coated tumourcells, that are normally resistant to NK cells.
PMID 8485905
Model Abstract

Entity

e1: e10: e11:Zymosan:CD11b:CD18 e12:E.Coli e13:E.coli:CD11b:CD18 e14:iC3b e15:iC3b:CD11b:CD18 e16:zymosan:CD11b{p}:CD18{p} e17:PKC e18:staurosporine e19:LPS e2: e20:LPS:CD11b:CD18 e21:lectin e22:lectin:CD11b:CD18 e23:L-selectin e24:L-selectin:CD11b:CD18 e25:glucans e26:glucans:CD11b:CD18 e27:MoAbOKM1 e28:tyrosine kinase e29:genistein e3: e30:herbimycin A e4: e5:CD11b:CD18 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Zymosan e60: e61: e62: e7: e8: e9:

Process

p1 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
166.75, 76.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
189.0, 96.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
968.5, 290.0
31.0, 60.0

Zymosan:CD11b:CD18

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p4 p9

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1215.5, 282.0
41.0, 60.0

E.Coli

--

e12

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
972.5, 394.0
31.0, 60.0

E.coli:CD11b:CD18

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1192.0, 412.6557657476353
48.39605554437512, 29.844234252364664

iC3b

--

e14

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
972.5, 494.0
31.0, 60.0

iC3b:CD11b:CD18

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
972.5, 102.0
31.0, 60.0

zymosan:CD11b{p}:CD18{p}

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4 p9

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
329.0, 302.58
46.56, 34.92

PKC

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7 p4

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
882.0, 419.0
60.0, 34.0

staurosporine

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1222.0, 559.0
60.0, 34.0

LPS

--

e19

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
166.75, 76.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
972.5, 602.0
31.0, 60.0

LPS:CD11b:CD18

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1251.0, 674.1748681898067
42.03866432337434, 27.325131810193323

lectin

--

e21

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
972.5, 698.0
31.0, 60.0

lectin:CD11b:CD18

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1206.0, 112.14640772791307
52.465284765546386, 32.353592272086935

L-selectin

--

e23

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
824.5, 70.0
31.0, 60.0

L-selectin:CD11b:CD18

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1214.0, 771.0
60.0, 34.0

glucans

--

e25

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
972.5, 794.0
31.0, 60.0

glucans:CD11b:CD18

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1325.0, 94.38461538461539
29.076923076923077, 43.615384615384606

MoAbOKM1

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
586.0, 252.0
20.916744621141255, 48.26941066417212

tyrosine kinase

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
654.0, 355.0
60.0, 34.0

genistein

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
183.87518862352903, 94.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
802.0, 651.0
60.0, 34.0

herbimycin A

--

e30

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
215.55678757705792, 124.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
968.5, 198.0
39.0, 60.0

CD11b:CD18

--

e5

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1 p2 p3 p5 p6 p7 p8

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
331.0, 761.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
381.29367619468036, 771.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
337.06992643728904, 766.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
337.93705878547314, 767.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
331.0, 761.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
331.0, 761.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
337.93705878547314, 767.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
670.9158804881849, 934.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
594.6082338479803, 1055.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
331.0, 761.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1310.0, 207.0
60.0, 34.0

Zymosan

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
440.7511016961721, 948.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
440.25867587120234, 927.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
461.43298634490145, 986.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
184.0, 77.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
164.0, 70.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
172.0, 91.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1157.0, 213.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c26 : 1
stoichiometry:c3 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 8485905, 3040333 Both zymosan (cell wall extract from the yeast Saccharomyces cereviseae) and Escherichia coli bind to resting CR3 and promote the phagocytically active state of CR3. beta-glucan component of zymosan, was responsible for CR3-dependent responses to iC3b-opsonized zymosan. CR3-dependent responses to fl-glucan were blocked by the CR3 alpha chain-specific MoAb OKMI.

Go back
1117.0, 301.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m5*m12*0.1

nodelay

--

true

0

false

PMID: 8485905 Both zymosan (cell wall extract from the yeast Saccharomyces cereviseae) and Escherichia coli bind to resting CR3 and promote the phagocytically active state of CR3.

Go back
1112.0, 420.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m5*m14*0.1

nodelay

--

true

0

false

PMID: 8485905, 833545, 573303, 7430626, 7252421, 7049467 Fixed iC3b on sheep erythrocytes (EC3bi) binds avidly to neutrophil, monocyte, and NK cell CR3, but does not trigger any cytotoxic reaction.

Go back
899.0, 307.0
25.0, 25.0

p4

p4

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c10 : 1
stoichiometry:c20 : 1

m17*m11*0.1

nodelay

--

true

0

false

PMID: 8485905, 1976698, 1673986 CR3 is capable of mediating phagocytosis following protein kinase C (PKC)-dependent activation. Blockade of both PMA- induced phagocytosis and homotypic aggregation by the PKC inhibitor staurosporine suggests a similar activation pathway for these two CR3-dependent functions. Neutrophil aggregation and phagocytosis of EC3bi induced by PMA were blocked by staurosporine suggested that a PKC-associated phosphorylation event was required for CR3 activation. beta-glucan derived from zymosan binds to CR3 and activates the receptor via a phosphorylation event involving both PKC and a tyrosine kinase.

Go back
1116.0, 564.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c14 : 1

m19*m5*0.1

nodelay

--

true

0

false

PMID: 8485905, 3537192 Lipopolysaccharide (LPS) on E. coli appears to bind to CR3 at a distinct site from beta-glucan and also stimulates CR3-dependent phagocytosis.

Go back
1111.0, 675.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m5*m21*0.1

nodelay

--

true

0

false

PMID: 8485905, 1682263 certain fimbriated strains of E. coli stimulate CR3- dependent phagocytosis by way of a mannose-specific lectin on the bacteria that binds to a carbohydrate on CR3.

Go back
1139.0, 39.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c28 : 1
stoichiometry:c32 : 1
stoichiometry:c23 : 1

m23*m5*m17*0.1

nodelay

--

true

0

false

PMID: 8485905, 1383326, 3283242, 1976698 Neutrophil homotypic aggregation requires PKC for exposure of a CR3 binding site for a counter-receptor on other neutrophils recently shown to be L-selectin.

Go back
1107.0, 775.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c22 : 1

m25*m5*0.1

nodelay

--

true

0

false

PMID: 8485905, 2579146 soluble glucans from barley or laminarin bound weakly to CR3.

Go back
819.0, 263.0
25.0, 25.0

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c27 : 1
stoichiometry:c11 : 1

m28*m11*0.1

nodelay

--

true

0

false

PMID: 8485905 beta-glucan derived from zymosan binds to CR3 and activates the receptor via a phosphorylation event involving both PKC and a tyrosine kinase. glucan-induced phagocytosis of EC3bi is not only prevented by staurosporine,but it is also blocked by genistein or herbimycin A, two tyrosine kinase inhibitors.

Go back
1008.0, 224.21468775313318

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.0, 320.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 151.42434732716472

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
376.0, 320.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0, 336.0

c13

c13

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1011.4232337800247, 581.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1147.0, 576.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 258.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
997.0, 258.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.0, 688.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1011.6840091603793, 692.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1186.0, 224.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0, 169.41006085515437

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1169.7688376822994, 68.54260875358183

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1011.7198375769518, 792.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.9050260054927, 54.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1140.0, 788.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.0, 258.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1181.3803153442088, 125.0

c26

c26

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
851.6875328973059, 281.2140094744241

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1008.0, 69.85796897515881

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.0, 276.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1007.0910674216556, 230.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.0, 286.18319483238696

c30

c30

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
832.0, 292.0

c31

c31

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
376.0, 58.54472776006838

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1008.0, 240.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1146.0, 312.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1010.230779471832, 321.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1008.0, 257.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1142.9889426346601, 429.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1010.599458978568, 440.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back