PMID: 9287290,2988123 This receptor, known as the apoB,E receptor or the LDL receptor (LDL-R), is a ubiquitous cell surface transmembrane protein PMID: 9287290,7627719,1464611,7510705,8349628 Inflammatory mediators such as growth factors and cytokines can promote the binding and uptake of LDL. These mediators include PDGF,TGF-beta ,basic fibroblast growth factor, TNF-alpha and IL-1

PMID: 9287190 Ligands for class A receptors include acetylated LDL, oxidized LDL, fucoidan, and carrageenan.

PMID: 9287290,7538425 These receptors bind oxidized LDL, apoptotic cells, and anionic phospholipids

PMID: 9287290,7538425 These receptors bind oxidized LDL, apoptotic cells, and anionic phospholipids

PMID: 9287290,7538425 These receptors bind oxidized LDL, apoptotic cells, and anionic phospholipids

PMID: 9287290,2988123 This receptor, known as the apoB,E receptor or the LDL receptor (LDL-R), is a ubiquitous cell surface transmembrane protein PMID: 9287290,7627719,1464611,7510705,8349628 Inflammatory mediators such as growth factors and cytokines can promote the binding and uptake of LDL. These mediators include PDGF,TGF-beta ,basic fibroblast growth factor, TNF-alpha and IL-1

PMID: 9287290,2988123 This receptor, known as the apoB,E receptor or the LDL receptor (LDL-R), is a ubiquitous cell surface transmembrane protein PMID: 9287290,7627719,1464611,7510705,8349628 Inflammatory mediators such as growth factors and cytokines can promote the binding and uptake of LDL. These mediators include PDGF,TGF-beta ,basic fibroblast growth factor, TNF-alpha and IL-1

PMID: 9287290,2988123 This receptor, known as the apoB,E receptor or the LDL receptor (LDL-R), is a ubiquitous cell surface transmembrane protein PMID: 9287290,7627719,1464611,7510705,8349628 Inflammatory mediators such as growth factors and cytokines can promote the binding and uptake of LDL. These mediators include PDGF,TGF-beta ,basic fibroblast growth factor, TNF-alpha and IL-1

PMID: 9287290,2988123 This receptor, known as the apoB,E receptor or the LDL receptor (LDL-R), is a ubiquitous cell surface transmembrane protein PMID: 9287290,7627719,1464611,7510705,8349628 Inflammatory mediators such as growth factors and cytokines can promote the binding and uptake of LDL. These mediators include PDGF,TGF-beta ,basic fibroblast growth factor, TNF-alpha and IL-1

PMID: 9287290,3571245 LDL can also directly stimulate PDGF production in endothelial cells

PMID: 9287190 Another important receptor is the apoE receptor found principally in hepatic cells and macrophages. It is mainly responsible for the binding and internalization of chylomicron remnants as well as apoE-containing HDL

PMID: 9287290 LDL entrapped within the arterial wall can undergo progressive oxidation producing minimally oxidized LDL particles (mm-LDL) or molecular Trojan horses.

PMID: 9287290,7729036 These molecular Trojan horses, like plasma LDL, can bind to the LDL-R but, unlike native LDL, bear a cargo of biologically active products of lipid peroxidation

PMID: 9287190 The uptake of these "cellular saboteurs" not only produces internalization of bioactive macromolecules and lipid peroxide products but also facilitates lipoprotein-derived CE accumulation characteristic of arterial "foam" cell formation.

PMID: 9287190 The uptake of these "cellular saboteurs" not only produces internalization of bioactive macromolecules and lipid peroxide products but also facilitates lipoprotein-derived CE accumulation characteristic of arterial "foam" cell formation.

PMID: 9287190 The uptake of these "cellular saboteurs" not only produces internalization of bioactive macromolecules and lipid peroxide products but also facilitates lipoprotein-derived CE accumulation characteristic of arterial "foam" cell formation.

PMID: 9287190 The uptake of these "cellular saboteurs" not only produces internalization of bioactive macromolecules and lipid peroxide products but also facilitates lipoprotein-derived CE accumulation characteristic of arterial "foam" cell formation.

PMID: 9287290,8962141 A third class of scavenger receptors has been reported recently by Steinberg and colleagues to be macrosialin/CD68, a family of endosomal proteins with sequence homology similar to the lysosomal-associated membrane proteins.The role of these lysosomal-associated membrane proteins in the uptake of oxidized LDL during atherogenesis remains to be elucidated.

PMID: 9287190 The uptake of these "cellular saboteurs" not only produces internalization of bioactive macromolecules and lipid peroxide products but also facilitates lipoprotein-derived CE accumulation characteristic of arterial "foam" cell formation.

PMID: 9287190 Another important receptor is the apoE receptor found principally in hepatic cells and macrophages. It is mainly responsible for the binding and internalization of chylomicron remnants as well as apoE-containing HDL

PMID: 9287290 Inflammatory mediators such as growth factors and cytokines can promote the binding and uptake of LDL.

PMID: 9287190 Ligands for class A receptors include acetylated LDL, oxidized LDL, fucoidan, and carrageenan.

PMID: 9287190 The uptake of these "cellular saboteurs" not only produces internalization of bioactive macromolecules and lipid peroxide products but also facilitates lipoprotein-derived CE accumulation characteristic of arterial "foam" cell formation.

PMID: 9297290 Finally, lipid peroxidation products borne by molecular Trojan horses and cellular saboteurs can activate the cell to produce inflammatory cytokines, chemokines, or growth factors, which can deliver cholesterol/CE to the cell by enhancing the expression of lipoprotein receptors, resulting in the eventual cellular engorgement of cholesterol.

PMID: 9297290 Finally, lipid peroxidation products borne by molecular Trojan horses and cellular saboteurs can activate the cell to produce inflammatory cytokines, chemokines, or growth factors, which can deliver cholesterol/CE to the cell by enhancing the expression of lipoprotein receptors, resulting in the eventual cellular engorgement of cholesterol.

PMID: 9297290 Finally, lipid peroxidation products borne by molecular Trojan horses and cellular saboteurs can activate the cell to produce inflammatory cytokines, chemokines, or growth factors, which can deliver cholesterol/CE to the cell by enhancing the expression of lipoprotein receptors, resulting in the eventual cellular engorgement of cholesterol.

PMID: 9297290 Finally, lipid peroxidation products borne by molecular Trojan horses and cellular saboteurs can activate the cell to produce inflammatory cytokines, chemokines, or growth factors, which can deliver cholesterol/CE to the cell by enhancing the expression of lipoprotein receptors, resulting in the eventual cellular engorgement of cholesterol.

PMID: 9297290 Finally, lipid peroxidation products borne by molecular Trojan horses and cellular saboteurs can activate the cell to produce inflammatory cytokines, chemokines, or growth factors, which can deliver cholesterol/CE to the cell by enhancing the expression of lipoprotein receptors, resulting in the eventual cellular engorgement of cholesterol.

PMID: 9297290 Finally, lipid peroxidation products borne by molecular Trojan horses and cellular saboteurs can activate the cell to produce inflammatory cytokines, chemokines, or growth factors, which can deliver cholesterol/CE to the cell by enhancing the expression of lipoprotein receptors, resulting in the eventual cellular engorgement of cholesterol.

PMID: 9287290,8673557 The cellular acquisition of bioactive lipids induces endothelial cell responses predisposing to atherogenesis, and these include the ability to induce expression of monocyte-specific adhesion molecules, expression of the monocyte chemoattractant protein-1, synthesis of monocyte colony-stimulating factor (M-CSF), and tissue factor production

PMID: 9287290,8673557 The cellular acquisition of bioactive lipids induces endothelial cell responses predisposing to atherogenesis, and these include the ability to induce expression of monocyte-specific adhesion molecules, expression of the monocyte chemoattractant protein-1, synthesis of monocyte colony-stimulating factor (M-CSF), and tissue factor production

PMID: 9287290,8673557 The cellular acquisition of bioactive lipids induces endothelial cell responses predisposing to atherogenesis, and these include the ability to induce expression of monocyte-specific adhesion molecules, expression of the monocyte chemoattractant protein-1, synthesis of monocyte colony-stimulating factor (M-CSF), and tissue factor production

PMID: 9287190 Ligands for class A receptors include acetylated LDL, oxidized LDL, fucoidan, and carrageenan.

PMID: 9287290,8673557 The cellular acquisition of bioactive lipids induces endothelial cell responses predisposing to atherogenesis, and these include the ability to induce expression of monocyte-specific adhesion molecules, expression of the monocyte chemoattractant protein-1, synthesis of monocyte colony-stimulating factor (M-CSF), and tissue factor production