1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/9792624.csml convertedTime:2009.07.01.11:24

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The role of C/EBP isoforms in the control of inflammatory and native immunityfunctions.
Authors Poli V.
Affiliation Department of Biochemistry, University of Dundee, Scotland, United Kingdom.vpoli@bad.dundee.ac.uk
Abstract
PMID 9792624
Model Abstract

Entity

G010325:C/EBPalpha G010787:C/EBPbeta MO000000009:Raf MO000000018:MEK{active} MO000000058:NF-kappaB MO000000077:MAPKs MO000000104:PKC MO000000205:TNFR MO000000214:IL-1 MO000000289:TNF-alpha MO000007384:IL-6 MO000013122:STAT3{active} MO000016580:C/EBPbeta MO000016597:IL-1beta MO000016736:Ras MO000016882:LPS MO000016943:gp130 MO000018458:IL-6R e1: e10: e11:Calcium/calmodulin dependent kinase e12:calcium e13:C/EBPbeta{p} e14:PKC{active} e15:Ras{active} e16:NF-KappaB family proteins e17:C/EBPbeta:NF-KappaB family proteins e18:IL-1R e19:IL-1beta:Il-1R e2: e20:IL-6:gp130:IL-6R e21:TNFR:TRAF6 e22:NF-kappaB{active} e23:NF-kappaB{active} e24:MAPKs{active} e25:Raf{active} e26:MEK e27:MAPKs{active} e28:STAT3 e29:C/EBPbeta e3: e30:C/EBPbeta{p} e31:NF-M e32:C/EBP family proteins e33:Myeloid specific genes e4: e5:C/EBPdelta e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Turpentine oil e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p5 p6 p7 p8 p9
Model Detail
669.0, 1061.0
29.0, 29.0

C/EBPalpha

--

G010325

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93306

10

false

infinite

0

unit false false false
TRANSFACG010325

--

Go back
646.0, 982.0
28.0, 28.0

C/EBPbeta

--

G010787

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93693

10

false

infinite

0

unit false false false
TRANSFACG010787

--

Go back
665.0, 497.0
21.0, 21.0

Raf

--

MO000000009

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000009

--

Go back
549.0, 733.0
21.5, 21.5

MEK{active}

--

MO000000018

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000018

--

Go back
261.0, 933.0
22.0, 22.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p27

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
685.0, 737.0
22.0, 22.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
372.0, 468.0
24.0, 24.0

PKC

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
27.0, 1023.0
18.0, 18.0

TNFR

--

MO000000205

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m176

10

false

infinite

0

unit false false false
TRANSPATHMO000000205

--

Go back
87.0, 971.0
25.0, 25.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4 p12

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
86.0, 1126.0
19.0, 19.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8 p14 p25

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
86.0, 878.0
20.0, 20.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p11 p24

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
513.0, 821.0
21.5, 21.5

STAT3{active}

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
300.0, 716.0
24.0, 24.0

C/EBPbeta

--

MO000016580

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p19 p22

true true true true

csml-variable:Double

m1576

10

false

infinite

0

unit false false false
InterProIPR004827
TRANSPATHMO000016580

--

Go back
49.0, 805.0
22.0, 22.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
558.0, 374.0
19.0, 19.0

Ras

--

MO000016736

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p37 p39

true true true true

csml-variable:Double

m1688

10

false

infinite

0

unit false false false
TRANSPATHMO000016736

--

Go back
77.0, 1037.0
22.0, 22.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6 p13

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
38.0, 838.0
20.0, 20.0

gp130

--

MO000016943

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m1854

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000016943

--

Go back
34.0, 958.0
20.0, 20.0

IL-6R

--

MO000018458

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m3096

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000018458

--

Go back
125.52778578228248, 294.46846580868186
943.809405327163, 1370.4112565350397

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
138.62132368732017, 312.41456730347056
914.8403331948338, 1286.9231098194762

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
307.0, 466.5
26.399999999999995, 19.799999999999997

Calcium/calmodulin dependent kinase

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
284.5, 636.0
23.471684790283863, 23.86950995622087

calcium

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
435.0, 766.0
25.731707317073173, 20.585365853658537

C/EBPbeta{p}

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

p17 p19

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
444.0, 556.0
24.0, 24.0

PKC{active}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
598.0, 442.0
19.0, 19.0

Ras{active}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000016736

--

Go back
315.0, 766.5
25.600000000000005, 19.200000000000006

NF-KappaB family proteins

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
288.5, 866.0
22.830194967505413, 27.95534077653725

C/EBPbeta:NF-KappaB family proteins

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
148.5, 731.0
22.527240773286465, 34.657293497363796

IL-1R

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
151.5, 807.0
17.882262661696995, 34.610830958123216

IL-1beta:Il-1R

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
125.52778578228248, 294.46846580868186
943.809405327163, 1370.4112565350397

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
152.5, 940.0
22.955955221141497, 32.0315654248486

IL-6:gp130:IL-6R

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
155.5, 1084.0
16.964700723525542, 32.834904626178464

TNFR:TRAF6

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
281.0, 1105.0
22.0, 22.0

NF-kappaB{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
525.0, 1269.0
22.0, 22.0

NF-kappaB{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
613.0, 813.0
22.0, 22.0

MAPKs{active}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
549.0, 597.0
21.0, 21.0

Raf{active}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000009

--

Go back
661.0, 665.0
21.5, 21.5

MEK

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000018

--

Go back
617.0, 913.0
22.0, 22.0

MAPKs{active}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
397.0, 825.0
21.5, 21.5

STAT3

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
800.0, 1048.0
24.0, 24.0

C/EBPbeta

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR004827
TRANSPATHMO000016580

--

Go back
144.40397388882576, 313.3446539152252
906.0570291140767, 1332.6588803219533

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
775.0, 1170.0
25.731707317073173, 20.585365853658537

C/EBPbeta{p}

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
595.0, 1279.0
49.30795847750865, 26.29757785467128

NF-M

--

e31

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
861.5, 1341.0
13.753069027973435, 22.302274099416383

C/EBP family proteins

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40 p41

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
656.0, 1211.0
48.78892733564014, 26.02076124567474

Myeloid specific genes

--

e33

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
179.32492188593085, 346.3779831016757
836.2151331198666, 1266.5922219490515

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
667.0, 1161.0
42.560553633218, 22.698961937716263

C/EBPdelta

--

e5

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p2 p4 p5 p7 p9 p32 p36

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
343.3100579384137, 882.7829864205996
513.2614025325604, 465.47170024833724

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
398.7461125881128, 893.8139890270713
300.11933034492375, 451.13478956306994

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
350.00061625820496, 888.9956477175483
499.88028589297824, 453.04637765443897

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
350.9564103038895, 889.9514417632327
497.96869780160904, 451.13478956306994

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
343.3100579384137, 882.7829864205996
513.2614025325604, 465.47170024833724

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
343.3100579384137, 882.7829864205996
513.2614025325604, 465.47170024833724

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
350.9564103038895, 889.9514417632327
497.96869780160904, 451.13478956306994

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
717.9813238467264, 1073.941795557494
32.06575231336721, 29.02794419946929

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
633.8714478264926, 1207.7529619533198
90.80043434002465, 82.19828792886454

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
343.3100579384137, 882.7829864205996
513.2614025325604, 465.47170024833724

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
62.0, 1225.0
52.026913372582, 29.481917577796473

Turpentine oil

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p9 p10 p15

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
464.28288259220614, 1089.6347637866381
16.254234459794887, 7.826112888049398

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
463.7401076946569, 1066.295443192018
55.6344269988036, 100.14196859784641

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
487.0794282892774, 1131.428430897935
8.68439836078884, 8.684398360788846

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
137.9280647436976, 299.9831090403764
925.5829840604238, 1311.5271803660612

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
141.2348058000749, 323.1302964350177
887.9227856434613, 1289.2638847543058

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
150.05278195041438, 346.27748382965933
883.8689310708124, 1272.355511966051

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
476.0, 928.0
23.0, 23.0

p1

p1

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c49 : 1
stoichiometry:c2 : 1

m871*m1360*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha PMID: 9792624,9528783 In agreement with this idea, it has been recently demonstrated that Stat3 is involved in the IL-6-induced up-regulation of both C/EBPd and C/EBPb gene promoters

Go back
396.0, 1148.0
23.0, 23.0

p1

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

Go back
448.0, 956.0
23.0, 23.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

Go back
448.0, 1004.0
23.0, 23.0

p11

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

Go back
452.0, 1076.0
23.0, 23.0

p11

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

Go back
468.0, 1148.0
23.0, 23.0

p11

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

Go back
484.0, 1196.0
23.0, 23.0

p11

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

Go back
309.0, 561.0
21.0, 21.0

p16

p16

cso30:i:ME_ChangeInMaterialConcentration

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells

Go back
374.0, 610.0
19.0, 19.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m12*m1576*0.1

nodelay

--

true

0

false

PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells

Go back
445.0, 469.0
21.0, 21.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells

Go back
442.0, 630.0
19.0, 19.0

p17

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m14*m1576*0.1

nodelay

--

true

0

false

PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells

Go back
496.0, 1060.0
23.0, 23.0

p1

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c50 : 1
stoichiometry:c4 : 1

m871*m1360*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha PMID: 9792624,9528783 In agreement with this idea, it has been recently demonstrated that Stat3 is involved in the IL-6-induced up-regulation of both C/EBPd and C/EBPb gene promoters

Go back
473.0, 385.0
21.0, 21.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c87 : 1
stoichiometry:c42 : 1

m1688*m19*0.1

nodelay

--

true

0

false

PMID: 9792624,8384717 Finally, activation of mitogen-activated protein kinase following induction of the Ras pathway leads to phosphorylation of Thr-235 PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

Go back
724.0, 1012.0
23.0, 23.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c97 : 1

m30*m32*0.1

nodelay

--

true

0

false

PMID: 9792624,8384717 Finally, activation of mitogen-activated protein kinase following induction of the Ras pathway leads to phosphorylation of Thr-235 PMID: 9792624 Figure1

Go back
237.0, 793.0
21.0, 21.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m1576*m16*0.1

nodelay

--

true

0

false

PMID: 9792624,8321203,151883 Among those, the interactions with members of the NF-kB family of transcription factors (47, 48) are particularly intriguing because they link the pathways of two major mediators of inflammation, IL-1 and IL-6.

Go back
53.0, 737.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m1591*m18*0.1

nodelay

--

true

0

false

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

Go back
45.0, 889.0
21.0, 21.0

p23

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m3096*m1854*m871*0.1

nodelay

--

true

0

false

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

Go back
49.0, 1073.0
21.0, 21.0

p23

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m176*m230*0.1

nodelay

--

true

0

false

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

Go back
233.0, 1025.0
21.0, 21.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m21*m22*0.1

nodelay

--

true

0

false

PMID: 9792624 Figure1 PMID: 9792624 This suggests a sequential model in which the induction of inflammatory cytokines such as IL-1 and IL-6 in response to inflammatory stimuli would first trigger the activation of pre-existing, inactive forms of Stat3 and NF-kB

Go back
337.0, 841.0
21.0, 21.0

p26

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m19*m22*0.1

nodelay

--

true

0

false

PMID: 9792624 Figure1 PMID: 9792624 This suggests a sequential model in which the induction of inflammatory cytokines such as IL-1 and IL-6 in response to inflammatory stimuli would first trigger the activation of pre-existing, inactive forms of Stat3 and NF-kB

Go back
318.0, 1194.0
19.0, 19.0

p28

p28

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

Go back
618.0, 730.0
19.0, 19.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m69*m28*0.1

nodelay

--

true

0

false

--

Go back
544.0, 984.0
23.0, 23.0

p1

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m185*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

Go back
605.0, 525.0
21.0, 21.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m15*m26*0.1

nodelay

--

true

0

false

PMID: 9792624 Figure1

Go back
569.0, 653.0
21.0, 21.0

p30

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m27*m29*0.1

nodelay

--

true

0

false

PMID: 9792624 Figure1

Go back
593.0, 1233.0
21.0, 21.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

Go back
557.0, 1161.0
21.0, 21.0

p32

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

Go back
670.0, 850.0
19.0, 19.0

p34

p34

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 9792624 Figure1

Go back
725.0, 965.0
21.0, 21.0

p32

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

Go back
725.0, 1101.0
21.0, 21.0

p32

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

Go back
493.0, 501.0
21.0, 21.0

p20

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m21*m1688*0.1

nodelay

--

true

0

false

PMID: 9792624,8384717 Finally, activation of mitogen-activated protein kinase following induction of the Ras pathway leads to phosphorylation of Thr-235 PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

Go back
397.0, 877.0
21.0, 21.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m20*m31*0.1

nodelay

--

true

0

false

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

Go back
493.0, 621.0
21.0, 21.0

p38

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m20*m1688*0.1

nodelay

--

true

0

false

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

Go back
540.0, 1044.0
23.0, 23.0

p1

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m185*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

Go back
698.0, 1266.0
19.0, 19.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c98 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 9792624,8557032 Moreover, as already mentioned, C/EBP family members can specifically transactivate the promoters of several myeloid-specific genes, and the chicken homologue of C/EBPb, NF-M, is a myeloidspecific factor mediating eosinophils differentiation

Go back
750.0, 1218.0
19.0, 19.0

p40

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 9792624,8557032 Moreover, as already mentioned, C/EBP family members can specifically transactivate the promoters of several myeloid-specific genes, and the chicken homologue of C/EBPb, NF-M, is a myeloidspecific factor mediating eosinophils differentiation

Go back
408.0, 1100.0
23.0, 23.0

p1

p5

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

Go back
416.0, 1052.0
23.0, 23.0

p1

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

Go back
452.0, 1176.0
23.0, 23.0

p1

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

Go back
516.0, 1132.0
23.0, 23.0

p1

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

Go back
508.0, 1224.0
23.0, 23.0

p1

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

Go back
106.0, 889.0

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
431.0, 1114.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
773.2521958241872, 1243.034437755449

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
712.9921104517297, 1225.3552049089658

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
99.0, 1049.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
439.0, 1002.2613443642425

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
105.0, 1137.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
475.0, 1173.5817887447786

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
105.0, 1136.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
539.0, 1015.9657657132583

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
114.0, 1236.081214088897

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
531.0, 1182.8570997301326

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
114.0, 1164.9273254864577

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
499.0, 944.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
419.0, 1009.3692416694033

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
106.0, 890.0

c21

c21

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
471.0, 973.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
112.0, 985.0

c23

c23

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
471.0, 1019.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
99.0, 1049.0

c25

c25

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
475.0, 1077.4118243819914

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
105.0, 1137.0

c27

c27

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
491.0, 1085.0355382068822

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
114.0, 1209.3125549443134

c29

c29

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
106.0, 892.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
507.0, 1091.5768191995746

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.0, 486.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
302.4022870018617, 582.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.0, 625.4256292582156

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.0, 635.6564023547028

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
388.0, 629.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.0, 480.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.0, 490.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.319744306791, 580.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.0, 650.250312299017

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 1078.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.27334457462285, 649.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.90409627000884, 385.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.0, 401.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.0, 461.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
639.0, 934.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
754.2354527400921, 1032.4129494057038

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
262.1778465754876, 740.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.54879985706305, 781.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.0, 814.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.5029885994706, 843.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
112.0, 984.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.5150582239837, 843.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
61.0, 765.992766725465

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
82.0, 748.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
74.0, 756.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
46.0, 917.8911513906571

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
49.0, 858.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
73.66261028176922, 891.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
66.0, 905.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
40.0, 1041.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
71.53223058309652, 1100.592335393595

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
567.0, 996.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
70.0, 1086.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
172.0, 1049.9471228907585

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
249.39861277392316, 955.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 1046.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
169.0, 825.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
281.0, 868.1528676130632

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
295.67403409979585, 862.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
297.0, 1127.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 1207.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.9382230137094, 741.9922778767136

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
112.0, 986.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
633.2636750760037, 513.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
573.8596008605664, 546.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.0, 618.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
597.9218120408467, 666.1157481747672

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.9711902327327, 674.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.0, 741.3401177329985

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.3745886903887, 749.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.0, 1253.7005280535602

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
614.0, 1189.1811873607644

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.0, 1189.6650308939504

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
563.0, 1065.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
574.0, 1017.0884890651031

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.0, 831.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
642.0659023220582, 869.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
639.0, 929.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.7521162826164, 979.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.0, 935.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
701.9779530046029, 1122.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
169.0, 412.38109022996207

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
172.0, 528.923129633249

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.5777087639997, 393.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
99.0, 1050.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
514.0, 461.9691115068547

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
175.0, 893.1518893831892

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
408.0, 847.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.0, 840.4864683861663

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
175.0, 647.5186055935329

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.004160461246, 393.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.0, 467.9164942765226

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.0, 1035.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.8662560398757, 1278.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.2238047668167, 1283.4375346821403

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back