PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha PMID: 9792624,9528783 In agreement with this idea, it has been recently demonstrated that Stat3 is involved in the IL-6-induced up-regulation of both C/EBPd and C/EBPb gene promoters

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

PMID: 9792624,1371993 Conversely, C/EBPalpha is slightly down-regulated under the same conditions

PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells

PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells

PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells

PMID: 9792624,1314426,8336793 Phosphorylation of serine 276 has been shown to take place in a pituitary cell line in response to intracellular Ca21 increase via a calcium/calmodulin-dependent kinase; activation of the protein kinase C pathway causes phosphorylation of Ser-105 in HepG2 cells

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha PMID: 9792624,9528783 In agreement with this idea, it has been recently demonstrated that Stat3 is involved in the IL-6-induced up-regulation of both C/EBPd and C/EBPb gene promoters

PMID: 9792624,8384717 Finally, activation of mitogen-activated protein kinase following induction of the Ras pathway leads to phosphorylation of Thr-235 PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

PMID: 9792624,8384717 Finally, activation of mitogen-activated protein kinase following induction of the Ras pathway leads to phosphorylation of Thr-235 PMID: 9792624 Figure1

PMID: 9792624,8321203,151883 Among those, the interactions with members of the NF-kB family of transcription factors (47, 48) are particularly intriguing because they link the pathways of two major mediators of inflammation, IL-1 and IL-6.

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

PMID: 9792624 Figure1 PMID: 9792624 This suggests a sequential model in which the induction of inflammatory cytokines such as IL-1 and IL-6 in response to inflammatory stimuli would first trigger the activation of pre-existing, inactive forms of Stat3 and NF-kB

PMID: 9792624 Figure1 PMID: 9792624 This suggests a sequential model in which the induction of inflammatory cytokines such as IL-1 and IL-6 in response to inflammatory stimuli would first trigger the activation of pre-existing, inactive forms of Stat3 and NF-kB

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

--

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

PMID: 9792624 Figure1

PMID: 9792624 Figure1

PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

PMID: 9792624 Figure1

PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

PMID: 9792624,8384717 Finally, activation of mitogen-activated protein kinase following induction of the Ras pathway leads to phosphorylation of Thr-235 PMID: 9792624 Figure1 PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb.

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

PMID: 9792624 Both TNF-a and IL-1b are known to trigger nuclear translocation of NF-kB and activation of the Ras pathway, as well as transcriptional induction of C/EBPb and C/EBPd (whose mechanism is still unknown), whereas IL-6 mediates activation of Stat3 and of the Ras pathway, which ultimately leads to phosphorylation and activation of C/EBPb. PMID: 9792624 Figure1

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

PMID: 9792624,8557032 Moreover, as already mentioned, C/EBP family members can specifically transactivate the promoters of several myeloid-specific genes, and the chicken homologue of C/EBPb, NF-M, is a myeloidspecific factor mediating eosinophils differentiation

PMID: 9792624,8557032 Moreover, as already mentioned, C/EBP family members can specifically transactivate the promoters of several myeloid-specific genes, and the chicken homologue of C/EBPb, NF-M, is a myeloidspecific factor mediating eosinophils differentiation

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha

PMID: 9792624,9238507 It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha