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PMID: 9917870, 8376546
LPS, IL-1beta and TNF-alpha induce IL-1beta and IL-6 production in brain microvessel endothelial cells and smooth muscle/pericytes invitro.
PMID: 9917870, 8376546
LPS, IL-1beta and TNF-alpha induce IL-1beta and IL-6 production in brain microvessel endothelial cells and smooth muscle/pericytes invitro.
PMID: 9917870, 8376546
LPS, IL-1beta and TNF-alpha induce IL-1beta and IL-6 production in brain microvessel endothelial cells and smooth muscle/pericytes invitro.
indirect
PMID: 9917870, 8376546
LPS, IL-1beta and TNF-alpha induce IL-1beta and IL-6 production in brain microvessel endothelial cells and smooth muscle/pericytes invitro.
PMID: 9917870, 8376546
LPS, IL-1beta and TNF-alpha induce IL-1beta and IL-6 production in brain microvessel endothelial cells and smooth muscle/pericytes invitro.
indirect
PMID: 9917870, 9227582, 8724976, 8593576, 8891309
LPS or IL-beta injected iv or intraperitoneally (ip) induces cyclooxygenase-2 (COX-2) mRNA in cerebral blood vessels.
PMID: 9917870, 9227582, 8724976, 8593576, 8891309
LPS or IL-beta injected iv or intraperitoneally (ip) induces cyclooxygenase-2 (COX-2) mRNA in cerebral blood vessels.
PMID: 9917870, 8835720, 8593576
c-fos and COX-2 are induced in microglia along blood vessels in the OVLT region and its adjacent meninges after iv LPS.
PMID: 9917870, 1539653
The microinjection into the OVLT region of the COX inhibitor indomethacin abrogates the rise in intra-OVLT (and intra-POA) PGE2 levels induced by iv IL-1beta.
indirect
PMID: 9917870, 8835720, 8593576
c-fos and COX-2 are induced in microglia along blood vessels in the OVLT region and its adjacent meninges after iv LPS.
PMID: 9917870, 7914071
PGE1EP1 receptors are reportedly upregulated in the OVLT region after iv IL-1beta.
indirect
PMID: 9917870, 7864854
Although Kc synthesize IL-1 mRNA in vitro within 30 minutes after LPS treatment , they apparently are unable to secret its biologically active, mature form.
indirect
PMID: 99178790, 8027674, 7957239
In fact, LPS and IL-1beta stimulate the increased production of CPLA2 after some hours by inducing post-transcriptional modifications and de novo synthesis.
PMID: 99178790, 8027674, 7957239
In fact, LPS and IL-1beta stimulate the increased production of CPLA2 after some hours by inducing post-transcriptional modifications and de novo synthesis.
PMID: 9917870
However, LPS induced synthesis of PGE2 by macrophages is considerabloe delayed relative to its prompt appearance in blood , due to the slow activation by LPS of the cPLA2 that triggers the releaseof arachidonic acid from membrane phospholipids , on the one hand and the induction of COX-2 that selectively mediates the conversion of archidonic acid liberated in response to LPS into PGE2, on the ohter, as reviewed earlier.
indirect
PMID: 9917870
However, LPS induced synthesis of PGE2 by macrophages is considerabloe delayed relative to its prompt appearance in blood , due to the slow activation by LPS of the cPLA2 that triggers the releaseof arachidonic acid from membrane phospholipids , on the one hand and the induction of COX-2 that selectively mediates the conversion of archidonic acid liberated in response to LPS into PGE2, on the ohter, as reviewed earlier.
PMID: 9917870
However, LPS induced synthesis of PGE2 by macrophages is considerabloe delayed relative to its prompt appearance in blood , due to the slow activation by LPS of the cPLA2 that triggers the releaseof arachidonic acid from membrane phospholipids , on the one hand and the induction of COX-2 that selectively mediates the conversion of archidonic acid liberated in response to LPS into PGE2, on the ohter, as reviewed earlier.
indirect
PMID: 9917870, 3148653
PGE2 inhibits the LPS induced synthesis of Il-1beta and TNF-alpha in Kuppfer cells
indirect
PMID: 9917870, 3148653
PGE2 inhibits the LPS induced synthesis of Il-1beta and TNF-alpha in Kuppfer cells
indirect
PMID: 9917870
EP3 mRNA was recently found to be induced in the mouse in the nodose ganglion by systemis LPS and IL-1beta
PMID: 9917870
EP3 mRNA was recently found to be induced in the mouse in the nodose ganglion by systemis LPS and IL-1beta
indirect
PMID: 9917870
The subsequent conversion of this arachidonic acid to PGE2 is catalyzed by constitutive COX-1.
indirect
PMID: 9917870
PGE2 under these conditions could be generated indirectly through the hydrolysis of membrane associated phosphoinositide (PI) by PI-specific phospholipase C (PI-PLC).
PMID: 9917870
PI-PLC is activated by C.
PMID: 9917870
Our working hypothesis, therefore is that a single iv injection of a low , pyrogenic dose (2 microgram/kg) of LPS into concious guinea pigs activates C, generating C components that bind to their receptors on Kupffer cells (Kc).
PMID: 9917870
Our working hypothesis, therefore is that a single iv injection of a low , pyrogenic dose (2 microgram/kg) of LPS into concious guinea pigs activates C, generating C components that bind to their receptors on Kupffer cells (Kc).
PMID: 9917870
Our working hypothesis, therefore is that a single iv injection of a low , pyrogenic dose (2 microgram/kg) of LPS into concious guinea pigs activates C, generating C components that bind to their receptors on Kupffer cells (Kc).
PMID: 9917870
These cells (Kc) are thereby stimulated to quickly release one or more mediators (that may include PGE2) which, in turn bind to their receptors on nearby terminals of hepatic vagal branches.
PMID: 9917870
These cells (Kc) are thereby stimulated to quickly release one or more mediators (that may include PGE2) which, in turn bind to their receptors on nearby terminals of hepatic vagal branches.
PMID: 9917870, 8244278
C3a dose dependently stimulates PGE2 production by Kc within 2 minutes.
PMID: 9917870, 6432907
C5a and C5b-9 also potently stimulate macrophage PGE2 synthesis.
PMID: 9917870, 6432907
C5a and C5b-9 also potently stimulate macrophage PGE2 synthesis.
PMID: 9917870
Circulating LPS, IL-1beta and PGE2 induce c-fos, IL-1RI and PGE2EP3 receptor expression respectively in the nodose ganglion.
PMID: 9917870
Circulating LPS, IL-1beta and PGE2 induce c-fos, IL-1RI and PGE2EP3 receptor expression respectively in the nodose ganglion.
PMID: 9917870
Circulating LPS, IL-1beta and PGE2 induce c-fos, IL-1RI and PGE2EP3 receptor expression respectively in the nodose ganglion.
PMID: 9917870
Circulating LPS, IL-1beta and PGE2 induce c-fos, IL-1RI and PGE2EP3 receptor expression respectively in the nodose ganglion.
PMID: 9917870
Circulating LPS, IL-1beta and PGE2 induce c-fos, IL-1RI and PGE2EP3 receptor expression respectively in the nodose ganglion.
PMID: 9917870
Circulating LPS, IL-1beta and PGE2 induce c-fos, IL-1RI and PGE2EP3 receptor expression respectively in the nodose ganglion.
PMID: 9917870
Circulating LPS, IL-1beta and PGE2 induce c-fos, IL-1RI and PGE2EP3 receptor expression respectively in the nodose ganglion.
PMID: 9917870
However, LPS induced synthesis of PGE2 by macrophages is considerabloe delayed relative to its prompt appearance in blood , due to the slow activation by LPS of the cPLA2 that triggers the releaseof arachidonic acid from membrane phospholipids , on the one hand and the induction of COX-2 that selectively mediates the conversion of archidonic acid liberated in response to LPS into PGE2, on the ohter, as reviewed earlier.
PMID: 99178790, 8027674, 7957239
In fact, LPS and IL-1beta stimulate the increased production of CPLA2 after some hours by inducing post-transcriptional modifications and de novo synthesis.